Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior is developed. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers result in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer-released ITA inhibits bacterial growth on acetate. Translation to an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers demonstrate a rapid resolution of inflammation in comparison to a control polymer silicone, demonstrating the value of sustained biomimetic presentation of ITA.     

An image watermarking based on the pdf modeling and quantization effects in the wavelet domain

An image watermarking technique based on the concept of JPEG2000 algorithm is proposed. Biorthogonal wavelet 9/7 transform is used to provide a set of coefficients suitable for watermark embedding. The statistical properties of different subbands are analyzed in order to choose the number of decomposition levels and position of subbands, which will assure the best compromise between the watermark transparency and robustness. The JPEG2000 quantization is applied to avoid insignificant wavelet coefficients, while the remaining ones are used for watermarking. The optimal and blind watermark detection is based on the nonlinear score function and appropriate model of coefficients distribution. The performance of the proposed procedure is tested on examples with various images, showing robustness under different attacks, while maintaining high image quality.     

Bee colony optimization for the p-center problem

Bee colony optimization (BCO) is a relatively new meta-heuristic designed to deal with hard combinatorial optimization problems. It is biologically inspired method that explores collective intelligence applied by the honey bees during nectar collecting process. In this paper we apply BCO to the p-center problem in the case of symmetric distance matrix. On the contrary to the constructive variant of the BCO algorithm used in recent literature, we propose variant of BCO based on the improvement concept (BCOi). The BCOi has not been significantly used in the relevant BCO literature so far. In this paper it is proved that BCOi can be a very useful concept for solving difficult combinatorial problems. The numerical experiments performed on well-known benchmark problems show that the BCOi is competitive with other methods and it can generate high-quality solutions within negligible CPU times.     

Thermally Induced Microstructural Transformations of Fe72Si15B8V4Cu1 Alloy

Thermal stability, mechanism, and kinetics of thermally induced microstructural transformations and their effects on magnetic permeability of Fe₇₂Si₁₅B₈V₄Cu₁ alloy with combined amorphous/nanocrystalline structure were studied. DTA curves revealed two separated thermally activated exothermic events in the temperature ranges from 740 K to 820 K (467 °C to 547 °C) and 870 K to 930 K (597 °C to 657 °C). Crystalline phases present in the as-prepared and thermally treated alloy samples were identified, and their microstructural parameters were determined using XRD, while, to gain further insight into the mechanism of microstructural transformations, AFM and SEM–EDS analyses were performed. Deconvolution of the complex DTA peak into individual steps was conducted, and, in correlation with the results of microstructural analysis, kinetic triplets corresponding to individual transformation steps were determined, allowing for the estimation of the lifetimes of the alloy at different temperatures. Magnetic permeability measurements showed that, in spite of the influence of microstructural transformations on magnetic properties of the alloy, the favorable magnetic properties are retained over relatively a wide temperature range.

     

Determination of 200 °C Isothermal Section of Al-Ag-Ga Phase Diagram by Microanalysis,X-ray Diffraction,Hardness and Electrical Conductivity Measurements

Ternary Al-Ag-Ga system at 200 °C was experimentally and thermodynamically assessed. Isothermal section was extrapolated using optimized thermodynamic parameters for constitutive binary systems. Microstructure and phase composition of the selected alloy samples were analyzed using light microscopy, scanning electron microscopy combined with energy-dispersive spectrometry and x-ray powder diffraction technique. The obtained experimental results were found to be in a close agreement with the predicted phase equilibria. Hardness and electrical conductivity of the alloy samples from four vertical sections Al-Ag₈₀Ga₂₀, Al-Ag₆₀Ga₄₀, Ag-Al₈₀Ga₂₀ and Ag-Al₆₀Ga₄₀ of the ternary Al-Ag-Ga system at 200 °C were experimentally determined using Brinell method and eddy current measurements. Additionally, hardness of the individual phases present in the microstructure of the studied alloy samples was determined using Vickers microhardness test. Based on experimentally obtained results, isolines of Brinell hardness and electrical conductivity were calculated for the alloys from isothermal section of the ternary Al-Ag-Ga system at 200 °C.     

Palm Oil: A New Ethics of Visibility for the Production Landscape

The explosion of the palm oil industry in recent decades has transformed vast swathes of the Malaysian and Indonesian countryside. Milica Topalovic , Assistant Professor of Architecture and Territorial Planning at ETH Zurich, asserts that the resulting agro-industrial landscapes challenge the very concept of what is rural, and considers how such areas should be conceptualised.