Pefloxacin in leprosy

Fluoroquinolones, a new class of compounds characterised by broad antimicrobial spectrum including mycobacteria together with limited toxicity, have recently been introduced in the chemotherapy of various human infectious diseases. Pefloxacin, one of the members of this class, was recently demonstrated to be bactericidal against M.leprae in the mouse foot-pad model and clinically beneficial in lepromatous leprosy patients. Clinical response to standard MDT with added pefloxacin in ten previously untreated (both PB and MB) was compared with that in ten similar patients on MDT alone in the present trial. The results of chemotherapy were quantified by a method of clinical scoring. This pilot study showed that addition of pefloxacin led to significant and rapid clinical improvement. There were no side effects attributable to pefloxacin.     

Design of an Ultra-Compact and Highly-Sensitive Temperature Sensor Using Photonic Crystal Based Single Micro-Ring Resonator and Cascaded Micro-Ring Resonator

Silicon - In the present report, a photonic crystal based micro-ring resonator (MRR) structure is proposed which is very compact in size and has very fast response and is employed for temperature...     

Thermally Induced Microstructural Transformations of Fe72Si15B8V4Cu1 Alloy

Thermal stability, mechanism, and kinetics of thermally induced microstructural transformations and their effects on magnetic permeability of Fe₇₂Si₁₅B₈V₄Cu₁ alloy with combined amorphous/nanocrystalline structure were studied. DTA curves revealed two separated thermally activated exothermic events in the temperature ranges from 740 K to 820 K (467 °C to 547 °C) and 870 K to 930 K (597 °C to 657 °C). Crystalline phases present in the as-prepared and thermally treated alloy samples were identified, and their microstructural parameters were determined using XRD, while, to gain further insight into the mechanism of microstructural transformations, AFM and SEM–EDS analyses were performed. Deconvolution of the complex DTA peak into individual steps was conducted, and, in correlation with the results of microstructural analysis, kinetic triplets corresponding to individual transformation steps were determined, allowing for the estimation of the lifetimes of the alloy at different temperatures. Magnetic permeability measurements showed that, in spite of the influence of microstructural transformations on magnetic properties of the alloy, the favorable magnetic properties are retained over relatively a wide temperature range.

     

Determination of 200 °C Isothermal Section of Al-Ag-Ga Phase Diagram by Microanalysis,X-ray Diffraction,Hardness and Electrical Conductivity Measurements

Ternary Al-Ag-Ga system at 200 °C was experimentally and thermodynamically assessed. Isothermal section was extrapolated using optimized thermodynamic parameters for constitutive binary systems. Microstructure and phase composition of the selected alloy samples were analyzed using light microscopy, scanning electron microscopy combined with energy-dispersive spectrometry and x-ray powder diffraction technique. The obtained experimental results were found to be in a close agreement with the predicted phase equilibria. Hardness and electrical conductivity of the alloy samples from four vertical sections Al-Ag₈₀Ga₂₀, Al-Ag₆₀Ga₄₀, Ag-Al₈₀Ga₂₀ and Ag-Al₆₀Ga₄₀ of the ternary Al-Ag-Ga system at 200 °C were experimentally determined using Brinell method and eddy current measurements. Additionally, hardness of the individual phases present in the microstructure of the studied alloy samples was determined using Vickers microhardness test. Based on experimentally obtained results, isolines of Brinell hardness and electrical conductivity were calculated for the alloys from isothermal section of the ternary Al-Ag-Ga system at 200 °C.     

Modeling the drain current and its equation parameters for lightly doped symmetrical double-gate MOSFETs

A 2D model for the potential distribution in silicon film is derived for a symmetrical double gate MOSFET in weak inversion. This 2D potential distribution model is used to analytically derive an expression for the subthreshold slope and threshold voltage. A drain current model for lightly doped symmetrical DG MOSFETs is then presented by considering weak and strong inversion regions including short channel effects, series source to drain resistance and channel length modulation parameters. These derived models are compared with the simulation results of the SILVACO (Atlas) tool for different channel lengths and silicon film thicknesses. Lastly, the effect of the fixed oxide charge on the drain current model has been studied through simulation. It is observed that the obtained analytical models of symmetrical double gate MOSFETs are in good agreement with the simulated results for a channel length to silicon film thickness ratio greater than or equal to 2.     

Powder Compaction Dies and Compressibility of Various Materials

Powder Metallurgy and Metal Ceramics - Powder compaction is the most crucial process in powder metallurgy since almost all the desired properties of a material, such as a shape, size, density,...     

Evaluation of Three-Dimensional Bioprinted Human Cartilage Powder Combined with Micronized Subcutaneous Adipose Tissues for the Repair of Osteochondral Defects in Beagle Dogs

Cartilage lesions are difficult to repair due to low vascular distribution and may progress into osteoarthritis. Despite numerous attempts in the past, there is no proven method to regenerate hyaline cartilage. The purpose of this study was to investigate the ability to use a 3D printed biomatrix to repair a critical size femoral chondral defect using a canine weight-bearing model. The biomatrix was comprised of human costal-derived cartilage powder, micronized adipose tissue, and fibrin glue. Bilateral femoral condyle defects were treated on 12 mature beagles staged 12 weeks apart. Four groups, one control and three experimental, were used. Animals were euthanized at 32 weeks to collect samples. Significant differences between control and experimental groups were found in both regeneration pattern and tissue composition. In results, we observed that the experimental group with the treatment with cartilage powder and adipose tissue alleviated the inflammatory response. Moreover, it was found that the MOCART score was higher, and cartilage repair was more organized than in the other groups, suggesting that a combination of cartilage powder and adipose tissue has the potential to repair cartilage with a similarity to normal cartilage. Microscopically, there was a well-defined cartilage-like structure in which the mid junction below the surface layer was surrounded by a matrix composed of collagen type I, II, and proteoglycans. MRI examination revealed significant reduction of the inflammation level and progression of a cartilage-like growth in the experimental group. This canine study suggests a promising new surgical treatment for cartilage lesions.     

A Coordinated Framework of DG Allocation and Operating Strategy in Distribution System for Configuration Management under Varying Loading Patterns

Abstract

The distributed generation (DG) planning with the varying pattern of the practical load is difficult as it calls for the frequent changes in DG size and system configuration, which is neither feasible nor permissible. Rather such a DG size and a configuration, which can be utilized over a wider load pattern, are more acceptable. This work presents a coordinated approach for DG planning and system reconfiguration. While to operate a particular DG size and the system configuration over a wide range of loading pattern, the configurations are ranked under different probabilistic loading patterns. Based upon the ranking of the new configuration, the energy performance of the coordinated planning is evaluated. Further, the observations from coordinated planning are imposed on coordinated operation using harmony search algorithm (HSA). The proposed approach is tested for single as well as multi-objectives on a 33-node system. A significant improvement in the computational efforts and energy performance of the resulting configuration have been observed where losses have reduced to 81.11 and 53.77?kW with single DG and multi-DG allocation respectively.     

Thermoelastic analysis of laminated composite and sandwich shells considering the effects of transverse shear and normal deformations

Abstract

In the present study, thermoelastic analysis of laminated composite and sandwich shells (cylindrical/spherical) is presented using fifth-order shear and normal deformation theory. The significant characteristic of the present theory is that it includes the effects of both transverse shear and normal deformations. The mathematical formulation uses the principle of virtual work to derive the variationally consistent governing equations and traction free boundary conditions. To obtain the static solution, these governing equations are solved by employing Navier’s solution technique. The shell is subjected to a mechanical/thermal load sinusoidally distributed over the top surface of the shell. The thermal load linearly varies across the thickness of the shell. The present results are compared with other higher-order models and 3D elasticity solution wherever possible. Thermal stresses presented in this study will act as a benchmark for the future work.     

Gas Tungsten Arc Surface Alloying of T1-6A1-4V with Carbon

Ti-6A1-4V was surface alloyed with carbon using gas tungsten arc. Microstructural studies on scanning electron microscope showed that in the alloyed layer a cellular/dendritic phase was distributed in the matrix having an acicular structure. Analysis of the alloyed layer showed an average overall increase of 1.45 wt% in the carbon content. X-ray diffraction studies confirmed the presence of TiC in the alloyed zone. Electron probe microanalysis revealed that the cellular/dendritic phase was rich in carbon and had about 15 wt% carbon, whereas the matrix was depleted in carbon. We concluded from the detailed studies that the alloyed zone matrix was supersaturated with carbon in which TiC was distributed. As a result of this surface treatment, the alloyed layer hardness increased from 350 to 640 HV.