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Kumar Upendra Navaneet Shreyshi Kumar Neeraj Pandey Subhash Chandra 《Wireless Personal Communications》2020,114(3):2493-2510
Wireless Personal Communications - Internet of Things (IoT) involves all the surrounding with smart devices to Internet and has been gaining more recognition because it provides substantial... 相似文献
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The activity of the E6AP protein, a member of the ubiquitin transfer system, is regulated through the association-dissociation of its homo-trimeric structure. Under physiologic conditions, this protein is in a mixture of mono, di and tri-mere complexes, where the D543A mutation further destabilize the complex. These featured render this protein as an excellent model for a study of pre-dissociation events that can be detected by applying a cluster analysis of the ∼200 ns long trajectories. The analysis of the WT complex revealed inherent divergence of the subunits, each exhibiting multiplicity of configurations that differ in their energy. Surprisingly, the trimer is more stable than the subunits. The D543A mutation caused the trimer complex to assume many equi-potential configurations, rendering it more flexible than the subunits. The trimeric destabilization is not observed in a mutant that affects only the structure of the active site. We propose that the pre-dissociation configurations can be identified much earlier than the structural disintegration of a proteinous complex. 相似文献
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Chowdhury Dibyendu De Bishnu Prasad Maity Subir Kumar Singh Navaneet Kumar Kar Rajib Mandal Durbadal 《SILICON》2023,15(4):1679-1689
Silicon - In this paper, the performance of the Asymmetric Gate Graded Channel Gate-Stack Double Gate (AG-GCGS-DG) MOSFET-based biosensor has been investigated for dielectric-modulated (DM)... 相似文献
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