Estimation of dynamically evolving ellipsoids with applications to medical imaging

The estimation of dynamically evolving ellipsoids from noisy lower-dimensional projections is examined. In particular, this work describes a model-based approach using geometric reconstruction and recursive estimation techniques to obtain a dynamic estimate of left-ventricular ejection fraction from a gated set of planar myocardial perfusion images. The proposed approach differs from current ejection fraction estimation techniques both in the imaging modality used and in the subsequent processing which yields a dynamic ejection fraction estimate. For this work, the left ventricle is modeled as a dynamically evolving three-dimensional (3-D) ellipsoid. The left-ventricular outline observed in the myocardial perfusion images is then modeled as a dynamic, two-dimensional (2-D) ellipsoid, obtained as the projection of the former 3-D ellipsoid. This data is processed in two ways: first, as a 3-D dynamic ellipsoid reconstruction problem; second, each view is considered as a 2-D dynamic ellipse estimation problem and then the 3-D ejection fraction is obtained by combining the effective 2-D ejection fractions of each view. The approximating ellipsoids are reconstructed using a Rauch-Tung-Striebel smoothing filter, which produces an ejection fraction estimate that is more robust to noise since it is based on the entire data set; in contrast, traditional ejection fraction estimates are based only on true frames of data. Further, numerical studies of the sensitivity of this approach to unknown dynamics and projection geometry are presented, providing a rational basis for specifying system parameters. This investigation includes estimation of ejection fraction from both simulated and real data.     

Bioprocess Scale-up for Acetohydroxamic Acid Production by Hyperactive Acyltransferase of Immobilized Rhodococcus Pyridinivorans

Catalysis Letters - In this study, Rhodococcus pyridinivorans cells containing hyperactive acyltransferase was immobilized on various macromolecules based-polymeric matrices and used to improve...     

Traction Energy Cost Reduction of the WMATA Metrorail System

An energy cost reduction study was conducted on the Washington Metropolitan Area Transit Authority Metrorail system. Its primary objectives were to classify primary energy end uses and identify conservation methods which have the highest potential for reducing the electric bill. The effort involved analyzing present energy costs, developing cost- effective conservation strategies, determining the savings associated with the strategies by simulation, recommending appropriate strategies for implementation and outlining a program for executing the recommendations. Although the effort involved both traction and support energy, only the traction energy aspects of the study are reported. It is the first time that the energy management model developed for the transit industry by the Rail Systems Center at Carnegie-Mellon University was comprehensively applied to a rapid transit property. The application was verified by comparing the simulated results to actual data. For anl practical purposes, the simulated results agree to within three percent of the actual energy consumption. Four traction energy conservation strategies were recommended for implementation based on high benefit and low cost. These are coasting, passenger load factor improvement, planned catch-up operation, and regeneration of braking energy. All of these strategies have payback periods of less than three years.     

A proposal for minimum detectable compartment in MIRD dosimetry modelling

The accuracy of radiation dose estimates from radiopharmaceutical administrations has recently become more important for three main reasons: (i) clinical providers are demanding more information on diagnostic procedures; (ii) regulatory groups are scrutinizing dosimetry for research subjects; and (iii) accurate organ doses are crucial in therapeutic administrations. These dose estimates are a sensitive function of the residence times. Because most clinical data acquisition protocols are limited to the first 24 h after dose administration, the area under the remainder of the time-activity curve (TAC) must be estimated. Estimation methods range from assuming physical decay only (overly conservative) to extrapolating end point physiological kinetics (overly liberal). This study demonstrates how much the results from these two methods vary and develops an alternative method which more accurately estimates this remainder term. A method, called the minimum detectable compartment (MDC), is constructed so that an accurate dose estimate can be made with a realistic measure of the remainder term. The method for determining MDC uses standard hypothesis testing. Using an analogue of the traditional minimal detectable activity calculation, a model with and without constant compartments is fitted to the TAC. The size of the constant compartment is varied until the relative likelihood of the two models meets the desired measure of power and sensitivity. Computer simulations of a simple mono-exponential are used to demonstrate the MDC as a function of the model, the number of data points, the range of the data and the noise in the data. The MDC is a very sensitive function of the data range. It falls by more than 50% when the data range is increased from two to three half-lives. In addition, the MDC is moderately sensitive to the noise in the data and relatively insensitive to the number of data points. These findings suggest that the MDC method can also be uses a priori to indicate what type of data collection regimen is necessary to achieve a certain accuracy.     

Study of Band Structure Properties of Pnictide LaO1−xF x FeAs (x = 0, 0.2) Superconducting Compound

This paper reports on the band structure properties and changes in band structure of fluorine-doped LaO_1?x F _x FeAs (x = 0, 0.2) compound, measured using X-ray photoemission spectroscopy (XPS). The band structure of the superconducting compound is compared with nonsuperconducting parent compound LaOFeAs. With fluorine doping, a shift of the shallow core level is observed in XPS spectra, which may be a response of the band structure due to fluorine doping in the system. The balance of the chemical potential shift with the screening effect of conduction electrons near the Fe and As ions is discussed using nearly unchanged Fe 2p and As 3d core-level spectra. The La 3d core-level spectra shift towards the high energy, ～0.36 eV, may be due to the chemical potential shift caused by fluorine doping. In our valence band spectra, a small peak at around 0.2 eV is observed, which disappeared with the fluorine doping in the system, indicating a change of Fe 3d state from low spin to high spin states and also confirming the nature of Fe 3d electrons as itinerant, which is responsible for superconductivity in these compounds.     

Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading,Sustained Release,and Cellular Delivery of Therapeutical Proteins

A rationally designed two‐step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of ≈50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano‐carriers for cellular delivery applications of therapeutical biomolecules.     

Third-world managers' attitudes toward pollution.

Examined pollution awareness and concern over pollution among 120 Indian managers from several industries. Pollution attitudes were measured by questionnaire responses to the open-ended question, "What is your firm's position in regard to pollution of the environment (in your own words)?" Responses were content analyzed and coded into 3 categories: (a) nonaware (51%), (b) aware-lacking concern (30%), and (c) aware-concerned (19%). Pollution attitudes displayed significant relationships with both individual and organizational variables. It is concluded that although pollution is becoming a serious problem in India, awareness and concern are lagging compared to the more developed countries. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Study of the biodegradation behavior of soy protein‐grafted polyethylene by the soil burial method

In this article, we report on the biodegradation of soy‐protein‐grafted polyethylene, which was successfully synthesized by a graft copolymerization method with benzoyl peroxide as the radical initiator. The biodegradation behavior of the grafted polyethylene was ascertained by a soil burial test. The weight‐loss percentage was measured as a function of the number of days, and it was observed that the percentage weight loss increased with increasing number of days. To further substantiate the degradation, microanalysis of the soil containing the samples was carried out. An increase in microorganism colonies was observed with increasing number of days. The hydrolysis of the samples taken from the soil after a specified number of days also corroborated the findings and revealed a continuous loss of weight. The effect of the degradation of the grafted samples on the growth of plants (wheat and soybean) was studied, and we observed that the products of degradation were not harmful to the growth of the plants. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009