Complete single mode wavelength coverage over 40 nm with a superstructure grating DBR laser

The spectral characteristics of a widely tunable super structure grating distributed Bragg reflector (SSG-DBR) laser are investigated and the design considerations of the grating reflectors are given. By systematically adjusting the control currents of the two reflector sections and the phase section it is experimentally shown that every wavelength in an interval of 40 nm can be reached with a side-mode suppression usually better than 30 dB     

Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies

We have shown previously that expression of mRNA for somatostatin receptor subtype 2 (sst2) detected by in situ hybridization correlates to therapeutic outcome in patients with carcinoid tumors treated with somatostatin analogues. However, in situ hybridization is laborious and not practical in clinical routine work. We have, therefore, developed polyclonal antibodies directed against sst2 that may be used for immunohistochemistry on tissue specimens. The staining is specific and is highly correlated to expression of mRNA for sst2 (P < 0.01) as well as to tracer uptake at somatostatin receptor scintigraphy (P < 0.01). There is also a good correlation to the therapeutic response in carcinoid patients treated with somatostatin analogues (P < 0.05). Of 35 patients with carcinoid tumors included in this investigation, 25 stained positive with the antibodies. Twenty-two of these were investigated by somatostatin receptor scintigraphy and showed tracer uptake in metastases. An additional two patients that did not stain with the antibodies showed pathological uptake of the tracer in metastases, which might indicate binding to somatostatin receptor subtype 5. None of the 10 patients without positive immunostaining responded to somatostatin analogue treatment, whereas patients with a positive stain had a biochemical response or remained stable during treatment. Thus, these antibodies may be used to determine the presence of sst2 in carcinoid tumors and to select patients suitable for somatostatin analogue treatment. The method is easily applicable in clinical practice.     

Duodenoesophageal reflux induces esophageal adenocarcinoma without exogenous carcinogen

Central nervous system (CNS) disease is a major feature of simian immunodeficiency virus (SIV) infection of macaques. To define the spectrum of CNS lesions in SIV-infected macaques and the potential associations with viral strain and disease course, we performed a retrospective analysis of necropsies on 124 macaques with SIV-induced AIDS. Histologic evidence of CNS disease was observed in 71 (57.3%) of the 124 animals. SIV encephalitis was the most common CNS lesion occurring in 43.7% (31/71) of the animals with CNS disease and 25% of all animals. The incidence of SIVE correlated significantly with shortened survival (P=0.0207). In addition, SIVE was seen in 42.9% (15/35) of rapid progressors (animals that died within 200 days) compared to only 18% (16/89) of normal progressors (animals that lived longer than 200 days) (P=0.011). Animals with SIVE had higher viral loads in peripheral blood than those that did not, but this difference did not reach statistical significance. Similarly, while animals infected with uncloned SIVmac251 had a higher incidence of SIVE (27.5%; 14/51) than animals infected with molecularly cloned SIVmac239 and its T-cell tropic derivatives (18.5%; 10/54) this difference was not statistically significant. In this study rapid disease progression and SIVE were highly correlated making separation of viral determinants of virulence from those of neurovirulence difficult.     

Bed morphology, flow structure, and sediment transport at the outlet of Lake Huron and in the upper St. Clair River

An integrated multibeam echo sounder and acoustic Doppler current profiler field survey was conducted in July 2008 to investigate the morphodynamics of the St. Clair River at the outlet of Lake Huron. The principal morphological features of the upper St. Clair River included flow-transverse bedforms that appear weakly mobile, erosive bedforms in cohesive muds, thin non-cohesive veneers of weakly mobile sediment that cover an underlying cohesive (till or glacio-lacustrine) surface, and vegetation that covers the bed. The flow was characterized by acceleration as the banks constrict from Lake Huron into the St. Clair River, an approximately 1500-m long region of flow separation downstream from the Blue Water Bridge, and secondary flow connected to: i) channel curvature; ii) forcing of the flow by local bed topography, and iii) flow wakes in the lee side of ship wrecks. Nearshore, sand-sized, sediment from Lake Huron was capable of being transported into, and principally along, the banks of the upper St. Clair River by the measured flow. A comparison of bathymetric surveys conducted in 2007 and 2008 identifies that the gravel bed does undergo slow downstream movement, but that this movement does not appear to be generated by the mean flow, and could possibly be caused by ship-propeller-induced turbulence. The study results suggest that the measured mean flow and dredging within the channel have not produced major scour of the upper St. Clair River and that the recent fall in the level of Lake Huron is unlikely to have been caused by these mechanisms.     

Proteolytic specificity of Lactobacillus delbrueckli subsp. bulgaricus influences functional properties of mozzarella cheese

Low-moisture part-skim Mozzarella cheeses were manufactured from 2% fat milk and aged for 21 d. Treatments included cheeses made with one of three different strains of Lactobacillus delbrueckii ssp. bulgaricus in combination with a single strain of Streptococcus thermophilus. A fourth, control treatment consisted of cheeses made with only S. thermophilus. Although total proteolytic ability of these strains, as indicated by the o-phthaldialdehyde analysis, was similar in each of the three strains of L. bulgaricus, these strains exhibited different proteolytic specificities toward the peptide, alpha(s1)-CN (f 1-23). On the basis of their alpha(s1)-CN (f 1-23) cleavage patterns and a previously described classification, these strains were assigned to the groups I, III, and V. The objective of this study was to investigate the influence of lactobacilli proteolytic systems, based on specificity toward alpha(s1)-CN (f 1-23), on functionality of part-skim Mozzarella cheese. Moisture, fat, protein, salt-in-moisture, and moisture in nonfat substances content of cheeses made with groups I, III, and V strain were similar. Control cheese had a lower moisture content than did other treatments. Significant differences were observed in functional properties between cheeses manufactured using groups III and V strains. Cheeses made with groups I and III strains were similar in their meltability, hardness, cohesiveness, melt strength, and stretch quality. Meltability and cohesiveness increased with age, while melt strength and stretch quality decreased with age for all cheeses. Additionally, HPLC showed that total peak areas of water-soluble peptides derived from cleavage of alpha(s1)-CN (f 1-23) by different strains of lactobacilli could be highly correlated to meltability and stretch characteristics of cheeses made with those strains.     

Evaluation of Mean Velocity and Turbulence Measurements with ADCPs

To test the ability of acoustic Doppler current profilers (ADCPs) to measure turbulence, profiles measured with two pulse-to-pulse coherent ADCPs in a laboratory flume were compared to profiles measured with an acoustic Doppler velocimeter, and time series measured in the acoustic beam of the ADCPs were examined. A four-beam ADCP was used at a downstream station, while a three-beam ADCP was used at a downstream station and an upstream station. At the downstream station, where the turbulence intensity was low, both ADCPs reproduced the mean velocity profile well away from the flume boundaries; errors near the boundaries were due to transducer ringing, flow disturbance, and sidelobe interference. At the upstream station, where the turbulence intensity was higher, errors in the mean velocity were large. The four-beam ADCP measured the Reynolds stress profile accurately away from the bottom boundary, and these measurements can be used to estimate shear velocity. Estimates of Reynolds stress with a three-beam ADCP and turbulent kinetic energy with both ADCPs cannot be computed without further assumptions, and they are affected by flow inhomogeneity. Neither ADCP measured integral time scales to within 60%.     

A software-based dynamic-warp scheduling approach for load-balancing the Viola–Jones face detection algorithm on GPUs

Face detection is a key component in applications such as security surveillance and human–computer interaction systems, and real-time recognition is essential in many scenarios. The Viola–Jones algorithm is an attractive means of meeting the real time requirement, and has been widely implemented on custom hardware, FPGAs and GPUs. We demonstrate a GPU implementation that achieves competitive performance, but with low development costs. Our solution treats the irregularity inherent to the algorithm using a novel dynamic warp scheduling approach that eliminates thread divergence. This new scheme also employs a thread pool mechanism, which significantly alleviates the cost of creating, switching, and terminating threads. Compared to static thread scheduling, our dynamic warp scheduling approach reduces the execution time by a factor of 3. To maximize detection throughput, we also run on multiple GPUs, realizing 95.6 FPS on 5 Fermi GPUs.     

A novel integrated optics wavelength filter in InGaAsP-InP

An InGaAsP-InP integrated optics wavelength selective device is proposed and demonstrated. It utilizes coupling between epitaxial layers with different refractive indices and thicknesses. The device is suitable for integration to form, e.g., a monolithic receiver for wavelength division multiplexed optical communication systems. Design considerations are given. The filter bandwidth and center wavelength can be freely chosen, and bandwidths as narrow as 1.5 nm at 1.3 or 1.55 μm center wavelength are shown feasible. Electrical tuning is possible. Experimental filters show that devices can he fabricated with performance in good agreement with theory, The 22-nm -3-dB bandwidth at 1.12-μm center wavelength presently demonstrated is limited by the measurement system.     

Test for measuring the stretchability of melted cheese

A test for measuring the stretchability of cheese was developed by adapting a texture-profile analyzer to pull strands of cheese upwards from a reservoir of melted cheese. Seven different cheeses were analyzed using the Utah State University stretch test. The cheeses were also analyzed for apparent viscosity with a helical viscometer, for meltability using a tube melt test, and for stretch using the pizza-fork test. Cheese was placed into a stainless steel cup and tempered in a water bath at 60, 70, 80, or 90 degrees C for 30 min before analysis. The cup was then placed in a water-jacketed holder mounted on the base of the instrument. A three-pronged hook-shaped probe was lowered into the melted cheese and then pulled vertically until all cheese strands broke or 30 cm was reached. This produced a stretch profile as the probe was lifted through the reservoir of melted cheese and then pulled strands of cheese upwards. Three parameters were defined to characterize the stretchability of the cheese. The maximum load, obtained as the probe was lifted through the cheese, was defined as melt strength (F(M)). The distance to which cheese strands were lifted was defined as stretch length (SL). The load exerted on the probe as the strands of cheese were being stretched was defined as stretch quality (SQ). There was a correlation between F(M) and apparent viscosity. There was also some correlation between SL measured by the fork test and SL when the cheese was tested at 90 degrees C, but no correlation occurred at lower temperatures.