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排序方式: 共有88条查询结果,搜索用时 15 毫秒
1.
GM Gazzaniga G Angelini G Pastorino E Santoro M Lucchini ML Dal Prà 《Canadian Metallurgical Quarterly》1993,78(3):271-275
Four hundred forty-six patients with Tourette Syndrome (TS) and/or their parents completed a 52-item self-report survey about vocal and motor tics, and the frequency of associated co-morbid conditions of aggression, obsessions and compulsions, attentional problems, sleep disturbance, mood disturbance, anxiety, and self-mutilative behaviours which have been frequently reported in the literature on TS. Respondents also responded to an open-ended question regarding the most disabling aspects of TS. Results were analyzed within two age groups; under 18 years of age (N = 245) and 18 years of age or older (N = 177). Tics and associated conditions were the most frequently reported disabling aspect by both age groups. Subjects under age 18, however, reported significantly more frequent problems with hyperactivity, temper control, aggressive behaviours and sleepwalking than adults with TS. 相似文献
2.
3.
Javier Cuadrado Daniel Dopico Jose A. Perez Roland Pastorino 《Multibody System Dynamics》2012,27(1):3-19
This work is part of a project aimed to develop automotive real-time observers based on detailed nonlinear multibody models
and the extended Kalman filter (EKF). In previous works, a four-bar mechanism was studied to get insight into the problem.
Regarding the formulation of the equations of motion, it was concluded that the state-space reduction method known as matrix-R
is the most suitable one for this application. Regarding the sensors, it was shown that better stability, accuracy and efficiency
are obtained as the sensored magnitude is a lower derivative and when it is a generalized coordinate of the problem. In the
present work, the automotive problem has been addressed, through the selection of a Volkswagen Passat as a case-study. A model
of the car containing fifteen degrees of freedom has been developed. The observer algorithm that combines the equations of
motion and the integrator has been reformulated so that duplication of the problem size is avoided, in order to improve efficiency.
A maneuver of acceleration from rest and double lane change has been defined, and tests have been run for the “prototype,”
the “model” and the “observer,” all the three computational, with the model having 100 kg more than the prototype. Results
have shown that good convergence is obtained for position level sensors, but the computational cost is high, still far from
real-time performance. 相似文献
4.
M. Penco M. A. Pastorino E. Occhiello F. Garbassi R. Braglia G. Giannotta 《应用聚合物科学杂志》1995,57(3):329-334
Rubbers of different kind were tested as toughening agents of poly(ethylene terephthalate) (PET), noting significant morphological and mechanical differences. In particular, good results were obtained by using an ethylene–ethyl acrylate–glycidyl methacrylate copolymer. The resulting blend evidenced good particle distribution, and the latter was related to chemical interactions between the rubber epoxy groups and PET terminal groups, including the effect of low molecular weight and polymeric amine catalysts, and to extrusion conditions. © 1995 John Wiley & Sons, Inc. 相似文献
5.
Elvira Sondo Federico Cresta Cristina Pastorino Valeria Tomati Valeria Capurro Emanuela Pesce Mariateresa Lena Michele Iacomino Ave Maria Baffico Domenico Coviello Tiziano Bandiera Federico Zara Luis J. V. Galietta Renata Bocciardi Carlo Castellani Nicoletta Pedemonte 《International journal of molecular sciences》2022,23(6)
Loss-of-function mutations of the CFTR gene cause cystic fibrosis (CF) through a variety of molecular mechanisms involving altered expression, trafficking, and/or activity of the CFTR chloride channel. The most frequent mutation among CF patients, F508del, causes multiple defects that can be, however, overcome by a combination of three pharmacological agents that improve CFTR channel trafficking and gating, namely, elexacaftor, tezacaftor, and ivacaftor. This study was prompted by the evidence of two CF patients, compound heterozygous for F508del and a minimal function variant, who failed to obtain any beneficial effects following treatment with the triple drug combination. Functional studies on nasal epithelia generated in vitro from these patients confirmed the lack of response to pharmacological treatment. Molecular characterization highlighted the presence of an additional amino acid substitution, L467F, in cis with the F508del variant, demonstrating that both patients were carriers of a complex allele. Functional and biochemical assays in heterologous expression systems demonstrated that the double mutant L467F-F508del has a severely reduced activity, with negligible rescue by CFTR modulators. While further studies are needed to investigate the actual prevalence of the L467F-F508del allele, our results suggest that this complex allele should be taken into consideration as plausible cause in CF patients not responding to CFTR modulators. 相似文献
6.
A framework for risk assessment and decision-making strategies in dangerous good transportation 总被引:16,自引:0,他引:16
The risk from dangerous goods transport by road and strategies for selecting road load/routes are faced in this paper, by developing an original site-oriented framework of general applicability at local level. A realistic evaluation of the frequency must take into account on one side inherent factors (e.g. tunnels, rail bridges, bend radii, slope, characteristics of neighborhood, etc.) on the other side factors correlated to the traffic conditions (e.g. dangerous goods trucks, etc.). Field data were collected on the selected highway, by systematic investigation, providing input data for a database reporting tendencies and intrinsic parameter/site-oriented statistics. The developed technique was applied to a pilot area, considering both the individual risk and societal risk and making reference to flammable and explosive scenarios. In this way, a risk assessment, sensitive to route features and population exposed, is proposed, so that the overall uncertainties in risk analysis can be lowered. 相似文献
7.
U Pastorino G Muscolino M Valente S Andreani L Tavecchio M Infante G Terno G Ravasi 《Canadian Metallurgical Quarterly》1994,107(2):596-599
The reliability of polyglyconate monofilament (Maxon) suture for sternal closure was tested on 216 consecutive sternotomies, performed on 208 patients in our department from January 1986 to December 1990. The reason of sternotomy was primary lung cancer in 34 cases (16%), lung metastases in 127 (59%), and disorders of the thymus in 55 (25%). Mean age was 38 years (range 3 to 78 years); multiple lung resections were performed in 102 patients (average 7 lesions, range 2 to 30); maximum extent of the operation was pneumonectomy in 2 cases, lobectomy in 53, segmentectomy in 27, and wedge resection in 74. Prior chemotherapy had been administered in 75 cases (35%). A second sternotomy was performed in 8 cases. No cases of sternal dehiscence, sternal infection, or empyema were observed, after a median follow-up of 27 months. Overall perioperative mortality was 0.9% (2/216). Our series demonstrates the safety of polyglyconate monofilament (Maxon) suture for sternal closure. Absorbable sutures appear to be a safe alternative to steel wire closure in patients undergoing extended pulmonary or mediastinal resection. 相似文献
8.
Pastorino M. Massa A. Caorsi S. 《IEEE transactions on instrumentation and measurement》2000,49(3):573-578
The problem of reconstructing locations, shapes, and dielectric permittivity distributions of two-dimensional dielectric objects from measurements of the scattered electric field is addressed. A numerical approach is proposed which is based on a multi-illumination multiview processing. In particular, the inverse problem is recast as a global nonlinear optimization problem, which is solved by a genetic algorithm. The final objective of the approach is the image reconstruction of highly contrasted bodies 相似文献
9.
Massa A. Franceschini D. Franceschini G. Pastorino M. Raffetto M. Donelli M. 《Antennas and Propagation, IEEE Transactions on》2005,53(10):3118-3127
Genetic algorithms (GAs) are well-known optimization strategies able to deal with nonlinear functions as those arising in inverse scattering problems. However, they are computationally expensive, thus offering poor performances in terms of general efficiency when compared with inversion techniques based on deterministic optimization methods. In this paper, a parallel implementation of an inverse scattering procedure based on a suitable hybrid genetic algorithm is presented. The proposed strategy is aimed at reducing the overall clock time in order to make the approach competitive with gradient-based methods in terms of runtime, but preserving the capabilities of escaping from local minima. This result is achieved by exploiting the natural parallelism of evolutionary techniques and the searching capabilities of the hybrid approach . The effectiveness of the proposed implementation is demonstrated by considering a selected numerical benchmark related to two-dimensional scattering geometries. 相似文献
10.
An overconstrained version of the moment method is presented that is based on a redundant number of testing functions and the use of a pseudoinversion transformation to solve the related overdetermined system of equations. Preliminary results prove that numerical solutions to electromagnetic scattering problems involved in SAR calculation can also be reached by using limited computer resources.<> 相似文献