A new statistic in the one-way multivariate analysis of variance

In the multivariate one-way analysis of variance a test statistic based solely on the rank orders of the data is proposed. In the two group case the statistic simplifies to a test of Puri and Sen [19]. Monte Carlo simulation techniques are used to evaluate the performance of the test statistic under various distributions. These evaluation include the simulated significance levels and power functions. By the nature of the proposed test it is evident that the new procedure is easier to implement than other existing rank based tests.     

Quadratic statistics for the goodness-of-fit test of the inverseGaussian distribution

The problem of using a quadratic test to examine the goodness-of-fit of an inverse Gaussian distribution with unknown parameters is discussed. Tables of approximate critical values of Anderson-Darling, Cramer-von Mises, and Watson test statistics are presented in a format requiring only the sample size and the estimated value of the shape parameter. A relationship is found between the sample size and critical values of these test statistics, thus eliminating a need to interpolate among sample sizes given in the table. A power study showed that the proposed modified goodness-of-fit procedures have reasonably good power     

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase

The several hundred members of the eukaryotic protein kinase superfamily characterized to date share a similar catalytic domain structure, consisting of 12 conserved subdomains. Here we report the existence and wide occurrence in eukaryotes of a protein kinase with a completely different structure. We cloned and sequenced the human, mouse, rat, and Caenorhabditis elegans eukaryotic elongation factor-2 kinase (eEF-2 kinase) and found that with the exception of the ATP-binding site, they do not contain any sequence motifs characteristic of the eukaryotic protein kinase superfamily. Comparison of different eEF-2 kinase sequences reveals a highly conserved region of approximately 200 amino acids which was found to be homologous to the catalytic domain of the recently described myosin heavy chain kinase A (MHCK A) from Dictyostelium. This suggests that eEF-2 kinase and MHCK A are members of a new class of protein kinases with a novel catalytic domain structure.