A novel soft-switching full-bridge DC/DC converter: analysis,design considerations, and experimental results at 1.5 kW, 100 kHz

The addition of an external commutating inductor and two clamp diodes to the phase-shifted PWM (pulsewidth modulated) full-bridge DC/DC converter substantially reduces the switching losses of the transistors and the rectifier diodes, under all loading conditions. The authors give analyses, practical design considerations, and experimental results for a 1.5 kW converter with 60 V, 25 A output, operating at 100 kHz clock frequency and 95% efficiency     

Chitosan particles agglomerated scaffolds for cartilage and osteochondral tissue engineering approaches with adipose tissue derived stem cells

In the XML file of the original article, H. Redl’s affiliation is incorrect. It is listed correctly in both the paper and PDF versions of the article, and can be found below: The online version of the original article can be found at     

Analysis of the fatigue behaviour characterized by stiffness and permanent deformation for different distal volar radius compression plates

Fractures of the distal radius are with 10% the most frequent fractures of the human skeleton. In order to stabilize the fracture which is essential for succesful bone-healing, distal volar compression using dorsal compression plates is often used. Among the most important, but until now sparsely investigated criteria for implant-quality is the fatigue behaviour of the system of radius and stabilizing implant. Several types of implants were tested in combination with synthetic bones in the fatigue regime. The fatigue behaviour of samples was characterized using the parameters stiffness, tilting angle and reduction of the fracture gap which can be expressed by the permanent deformation of the system. The study of the evolution of these properties allows an interpretation of the mechanisms governing fatigue. Thus, a comparison of different implant types was obtained. Results show that the geometry of the implant as well as the positioning and type of the used screws has a profound effect on the characteristics of the system.     

Improved results after aggressive treatment of colonic involvement in necrotizing pancreatitis

BACKGROUND/AIMS: Colonic involvement is a rare but serious event in necrotizing pancreatitis. Early detection of this complication is difficult; a delay of diagnosis may lead to perforation and peritonitis. Two strategies of therapy have been developed in the last few years: an aggressive regimen of early resection and a conservative approach with ileostomy and observation. MATERIALS AND METHODS: Fourteen of 118 patients treated for necrotizing pancreatitis from 1988 to 1995 presented with colonic necrosis. The diagnosis of necrosis was made if the color of the bowel wall demonstrated ischemia or hemorrhagic infarction or pulsations of the mesocolic vessels could not be palpated. The first two patients were treated by a conservative approach the following 12 by immediate large bowel resection. Follow-up results of all surviving patients were obtained. RESULTS: Patients with colonic lesions demonstrated an advanced septic state compared to patients who did not present this complication. Differences in the average Apache 2 scores on admission and the incidence of multiple organ failure were significant (Apache 2 score; 16.6 versus 11.9, p = 0.028, Wilcoxon; multiple organ failure; 71% versus 35%, p = 0.028, Fisher's exact test). Results after establishment of early discontinuity-resection of colonic necrosis compared favorably to those of a conservative strategy (mortality 4/12; 33% versus 2/2; 100%). The overall mortality was 43% (6 of 14 patients). Restorative surgery was performed in 6 patients without substantial morbidity and no mortality. Follow-up results were satisfactory in the majority of the patients. CONCLUSIONS: Early resection of colonic lesions improves results in this dangerous complication of necrotizing pancreatitis.     

Small-Signal Dynamic Analysis of Regulated Class E DC/DC Converters

Class E dc/dc converters can operate at high switching frequencies with very low switching power losses. Using commercially available power transistors and diodes, Class E converters can operate at switching frequencies in the low-MHz range, with efficiencies of about 85 percent. Previous papers dealt with the circuit parameter values needed to obtain high-efficiency operation and output-voltage regulation, and with the static control characteristics of the Class E dc/dc converter cell. The analysis is extended to include the dynamic control characteristics and further information about the static characteristics. The theoretical predictions are verified by experimental measurements on a 40-W 1.5-MHz converter.     

Stiffness analysis of tibia-implant system under cyclic loading

A testing method has been developed to characterize stiffness and permanent deformation of bone-implant systems. The system consists of an artificial tibia with simulated distal fracture stabilized by an unreamed intramedullary nail. This system was loaded with three different sequences at 2 Hz, each consisting of 40,000 sinusoidal cycles, simulating clinical relevant loading conditions. Evaluation of the results showed a stiffness of 2782 N/mm with a standard deviation of 311 N/mm and a permanent deformation of 0.64 mm with a standard deviation of 0.21 mm. The locking screws broke exclusively during the third loading sequence starting with the most proximal of the distal screws. The study provides a standard technique for biomechanical testing and a comparison of different bone/implant-systems avoiding the variability of cadaver bone tests.     

DC-DC converter: four switches V/sub pk/=V/sub in//2, capacitive turn-off snubbing, ZV turn-on

A new four-switch full-bridge dc-dc converter topology is especially well-suited for power converters operating from high input voltage: it imposes only half of the input voltage across each of the four switches. The two legs of a full-bridge converter are connected in series with each other, across the dc input source, instead of the usual topology in which each leg is connected across the dc source. The topology reduces turn-off switching losses by providing capacitive snubbing of the turn-off voltage transient, and eliminates capacitor-discharge turn-on losses by providing zero-voltage turn-on. (Switching losses are especially important in converters operating at high input voltage because turn-on losses are proportional to the square of the input voltage, and turn-off losses are proportional to the input voltage). The topology is suitable for resonant and nonresonant converters. It adds one bypass capacitor and one commutating inductor to the minimum-topology full-bridge converter (that inductor is already present in many present-day converters, to provide zero-voltage turn-on, or is associated with one or two capacitors to provide resonant operation), and contains a dc-blocking capacitor in series with the output transformer, primary winding, and some nonresonant converters (that capacitor is already present in resonant power converters). The paper gives a theoretical analysis, and experimental data on a 1.5-kW example that was built and tested: 600-Vdc input, 60-Vdc output at up to 25A, and 50-kHz switching frequency. The measured performance agreed well with the theoretical predictions. The measured efficiency was 93.6% at full load, and was a maximum of 95.15% at 44.8% load.     

Spatial Imaging of Charge Transport in Germanium at Low Temperature

The purpose of this experiment is to observe the oblique propagation of electrons through germanium by exciting a point source of charge carriers with a focused laser pulse on one face of a germanium crystal. After the electrons are drifted through the crystal by a uniform electric field, the pattern of charge density arriving on the opposite face is mapped and used to reconstruct the trajectories of the electrons. These measurements will verify in detail the Monte Carlo analysis utilized in the Cryogenic Dark Matter Search to model the transport of charge carriers in high-purity germanium detectors, including both oblique electron propagation and inter-valley scattering.     

Development of Synthetic Platelet‐Activating Hydrogel Matrices to Induce Local Hemostasis

Several hemostatic strategies rely on the use of blood components such as fibrinogen and thrombin, which suffer from high cost and short shelf‐life. Here, a cost‐effective synthetic biomaterial is developed for rapid local hemostasis. Instead of using thrombin, thrombin‐receptor‐agonist‐peptide‐6 (TRAP6) is covalently engineered in polyvinyl alcohol (PVA) hydrogels. Soluble PVA‐TRAP6 is first prepared by covalent attachment of cysteine‐containing TRAP6 onto the backbone of PVA‐norbornenes (PVA‐NB) through photoconjugation. Cytotoxicity studies using C2C12 myoblasts indicate that PVA‐NB and PVA‐TRAP6 are nontoxic. Thromboelastography reveals that hemostatic activity of TRAP6 is retained in conjugated form, which is comparable to free TRAP6 solutions with equal concentrations. A 0.1% PVA‐TRAP6 solution can shorten the clotting time (CT) to ca. 45% of the physiological CT. High platelet‐activating efficiency is further confirmed by platelet aggregation assay and flow cytometry (FACS). For potential clinical applications, TRAP6‐presenting hydrogel particulates (PVA‐TRAP6‐P) are developed for local platelet activation and hemostasis. PVA‐TRAP6‐P is prepared by biofunctionalization of photopolymerized PVA‐NB hydrogel particulates (PVA‐NB‐P) with TRAP6. It is demonstrated that PVA‐TRAP6‐P can effectively shorten the CT to ca. 50%. FACS shows that PVA‐TRAP6‐P can activate platelets to a comparable extent as soluble TRAP6 control. Altogether, PVA‐TRAP6‐P represents a promising class of biomaterials for safe hemostasis and wound healing.