Wide- and narrow-band bandpass coplanar filters in the W-frequency band

This paper deals with the design of passive coplanar devices in the W-frequency band. As long as coplanar transmission lines are correctly dimensioned, analytical models based on quasi-TEM approximation can be used. Such models are associated with a correct definition of the reference planes at the junctions and employed for junction discontinuities, T- and cross-junctions. In order to validate these assertions, simulated and experimental data on classical quarter-wavelength shunt-stub filters are first presented. Then the design of traditional coupled-line filters is examined. The problems in terms of insertion loss associated with these kinds of narrow-band applications are discussed here. Minimization of insertion losses requires increasing the width of the strips. Consequently, the design becomes complex and modeling using transmission-line models less accurate. Nevertheless, as an optimization procedure is needed to tune the filter theoretically, such a very fast design method is necessary. Simulated and experimental results in the range 500 MHz to 110 GHz are compared throughout the paper.     

A high-frequency nonquasi-static analytical model including gate leakage effects for on-chip decoupling capacitors

This paper presents a compact model for on-chip decoupling capacitors (decaps) including gate-oxide leakage. The model makes use of only four parameters, namely, channel resistance, gate-oxide capacitance, and two parameters to quantify gate-oxide leakage, to predict the static and dynamic response of decaps. Quality indices have been defined to enable development of decap design guidelines and evaluation of performance of such capacitors. The model shows how the gate leakage and longer channel lengths severely affect the performance of on-chip decaps for both low and high frequencies. The model also shows that lumped models of decaps at high frequencies fail and have to be substituted by a distributed model. Application of the model uncovers tradeoffs for thin- and thick-oxide capacitors in an available 90-nm CMOS technology. For a general-purpose technology, a reference capacitance value has been realized using decaps with a discrete width and length. Our model predicts that thick-oxide n-channel (p-channel) capacitors require /spl sim/3.37x (/spl sim/3.31x) more silicon area and /spl sim/1.70x (/spl sim/1.17x) degraded time response as compared to their thin-oxide versions. The time response is even more degraded (/spl prop/L/sup 2/) when longer channel decaps are used. This paper contributes by defining performance benchmarks for decaps.     

The uniplanar technology: A convenient way to design multifunction subsystems and application to a biphase (0°–180°) modulator/mixer

This article outlines the high flexibility of the uniplanar technology to design complex multifunction subsystems. Furthermore, a design procedure, based on a subsystem repartition into elementary blocks and very simple electrical modeling, is proposed and applied to a uniplanar biphase (0°–180°) modulator/mixer. To start, this approach has been validated by experimentation on a subsystem up to 20 GHz. Next, preliminary results demonstrate the validity of this subsystem design procedure at millimeter-wave frequencies. © 1996 John Wiley & Sons, Inc.     

Medical therapy of Graves' disease: does thyroxine prevent recurrence of hyperthyroidism?

Sixty patients with Graves' disease (GD) hyperthyroidism were distributed in two randomized groups. Patients in group A (n = 30) received carbimazole by a titration regimen, and patients in group B (n = 30) were treated with higher doses of carbimazole plus T4. Clinical and analytical evaluations were done at baseline, during treatment (18.4 +/- 2.6 months), and after, until the relapse of hyperthyroidism, or for 4.98 +/- 1.6 yr in patients who did not relapse. There were no differences in clinical parameters, thyroid hormones, or TSH binding inhibitory immunoglobulins (TBII) levels between the two groups, either at baseline or at the end of treatment. Serum TSH persisted undetectable in 16 out of 60 patients (group A: 9; group B: 7), after treatment. Relapse occurred in 38 patients (63.3%), (group A: 18 (60%) vs. group B: 20 (66.7%)). Patients who relapsed had bigger goiters at baseline (P = 0.02) and at the end of treatment (P = 0.03). Eighty-seven percent (14/16) of patients with undetectable TSH after therapy relapsed, vs. 54.5% (24/44) of those with normal TSH (P = 0.01). Undetectable TSH at the end of treatment was the only independent variable in the logistic analysis to predict relapse. Treatment modality did not influence the relapse rate. This study has found that, in Spanish patients, the use of high doses of carbimazole with T4 offers no advantages in the treatment of GD hyperthyroidism.     

Proportional BIC sensor for current testing

A new design of a BIC sensor for current testing static CMOS circuits is proposed. It is based on a lateral BJT device which is easy to incorporate in any standard CMOS process. The design diverts a fraction of the I _DDQ current from the cell under test and a resistive component generates a voltage proportional to I _DDQ . Additional features are the possibility of continuous measure of i _dd and increased speed of this sensor compared with sensors based on the current integration principle. The design does not have substrate currents due to the parasitic vertical BJTs. Experimental work on the sensor is reported.     

Mechanisms of the effect of lead on brain neurotransmission: a calcium mediated action

Data on the effect of chronic lead ingestion on brain neurochemistry in laboratory rodents show the involvement of several neurotransmitters including catecholamines. In the case of dopamine (DA), the action of lead is not uniform in all the DA-innervated areas. The reason for the regional susceptibility to the effect of lead is at present unknown, but points to the existence of specific neuronal mechanisms. Results obtained from animals exposed from birth to lead show that calcium channels are differentially modified in various brain areas. In particular, calcium antagonists display regional sensitivity both after in vivo lead treatment and after in vitro lead addition. These data support the concept that the area selective effects of the metal on neurotransmission may depend on the mechanisms controlling nerve terminal activity in different neuronal populations.     

Ion-selective electrodes using carbon nanotubes as ion-to-electron transducers

This study developed a new type of all-solid-state ion-selective electrode based on a transducing layer of a network of single-walled carbon nanotubes. The extraordinary capacity of carbon nanotubes to promote electron transfer between heterogeneous phases made the presence of electroactive polymers or any other ion-to-electron-transfer promoter unnecessary. The new transducer layer was characterized by environmental scanning electron microscopy and electrochemical impedance spectroscopy. The stability of the electrical potential of the new solid-contact electrode was examined by performing current-reversal chronopotentiometry, and the influence of the interfacial water film was assessed by the potentiometric water layer test. The performance of the new electrode was evaluated by determining K+ with an ion-selective membrane that contained the well-known valinomycin ion carrier. The new electrode had a Nernstian slope (58.4 mV/decade), dynamic ranges of four logarithmic units, and selectivities and limits of detection comparable to other solid-contact electrodes. The short response time (less than 10 s for activities higher than 10(-5.5) M) and the stability of the signal over several days makes these new electrodes very promising candidates for attaining true miniaturization.