Constrained length minimum inductance gradient coil design

A gradient coil design algorithm capable of controlling the position of the homogeneous region of interest (ROI) with respect to the current-carrying wires is required for many advanced imaging and spectroscopy applications. A modified minimum inductance target field method that allows the placement of a set of constraints on the final current density is presented. This constrained current minimum inductance method is derived in the context of previous target field methods. Complete details are shown and all equations required for implementation of the algorithm are given. The method has been implemented on computer and applied to the design of both a 1:1 aspect ratio (length:diameter) central ROI and a 2:1 aspect ratio edge ROI gradient coil. The 1:1 design demonstrates that a general analytic method can be used to easily obtain very short gradient coil designs for use with specialized magnet systems. The edge gradient design demonstrates that designs that allow imaging of the neck region with a head sized gradient coil can be obtained, as well as other applications requiring edge-of-cylinder regions of uniformity.     

Acoustic noise reduction in a 4 T MRI scanner.

High-field, high-speed magnetic resonance imaging (MRI) can generate high levels of noise. There is ongoing concern in the medical and imaging research communities regarding the detrimental effects of high acoustic levels on auditory function, patient anxiety, verbal communication between patients and health care workers and ultimately MR image quality. In order to effectively suppress the noise levels inside MRI scanners, the sound field needs to be accurately measured and characterized. This paper presents the results of measurements of the sound radiation from a gradient coil cylinder within a 4 T MRI scanner under a variety of conditions. These measurement results show: (1) that noise levels can be significantly reduced through the use of an appropriately designed passive acoustic liner; and (2) the true noise levels that are experienced by patients during echo planar imaging.     

Characterization of vibration and acoustic noise in a gradient-coil insert

High-speed switching of current in gradient coils within high magnetic field strength magnetic resonance imaging (MRI) scanners results in high acoustic sound pressure levels (SPL) in and around these machines. To characterize the vibration properties as well as the acoustic noise properties of the gradient coil, a finite-element (FE) model was developed using the dimensional design specifications of an available gradient-coil insert and the concentration of the copper windings in the coil. This FE model was then validated using experimentally collected vibration data. A computational acoustic noise model was then developed based on the validated FE model. The validation of the finite-element analysis results was done using experimental modal testing of the same gradient coil in a free-free state (no boundary constraints). Based on the validated FE model, boundary conditions (supports) were added to the model to simulate the operating condition when the gradient-coil insert is in place in an MRI machine. Vibration analysis results from the FE model were again validated through experimental vibration testing with the gradient-coil insert installed in the MRI scanner and excited using swept sinusoidal time waveforms. The simulation results from the computational acoustic noise model were also validated through experimental noise measurement from the gradient-coil insert in the MRI scanner using swept sinusoidal time waveform inputs. Comparisons show that the FE model predicts the vibration properties and the computational acoustic noise model predicts the noise characteristic properties extremely accurately.     

Surface area loss of platinum supported on graphite

A study was conducted of the loss surface area of platinum when supported on both untreated and oxidized graphitized carbon black. The treatment of the graphite support was found to affect the rate of Pt area loss in a hot, concentrated H₃PO₄ solution with the support prepared using the iron oxide catalysed oxidation of the graphite resulting in the least loss of Pt surface area. This surface area loss was found to be relatively insensitive to electrode operating potential. A t-plot analysis of the nitrogen adsorption data on the support was used to explain the beneficial effect of the catalytically oxidized graphite. This study demonstrates that crystallite migration is the mechanism of supported Pt surface area loss in H₃PO₄ electrolyte.     

Large-scale biomedical image analysis in grid environments

This paper presents the application of a component-based Grid middleware system for processing extremely large images obtained from digital microscopy devices. We have developed parallel, out-of-core techniques for different classes of data processing operations employed on images from confocal microscopy scanners. These techniques are combined into a data preprocessing and analysis pipeline using the component-based middleware system. The experimental results show that: 1) our implementation achieves good performance and can handle very large datasets on high-performance Grid nodes, consisting of computation and/or storage clusters and 2) it can take advantage of Grid nodes connected over high-bandwidth wide-area networks by combining task and data parallelism.     

Ex-vivo cellular MRI with b-SSFP: quantitative benefits of 3 T over 1.5 T

INTRODUCTION: The use of MRI with iron-based magnetic nanoparticles for imaging cells is a rapidly growing field of research. We have recently reported that single iron-labeled cells could be detected, as signal voids, in vivo in mouse brains using a balanced steady-state free precession imaging sequence (b-SSFP) and a customized microimaging system at 1.5 T. METHODS: In the current study we assess the benefits, and challenges, of using a higher magnetic field strength for imaging iron-labeled cells with b-SSFP, using ex vivo mouse brain specimens imaged with near identical systems at 1.5 and 3.0 T. RESULTS: The substantial banding artifact that appears in 3 T b-SSFP images was readily minimized with RF phase cycling, allowing for banding-free b-SSFP images to be compared between the two field strengths. This study revealed that with an optimal 3 T b-SSFP imaging protocol, more than twice as many signal voids were detected as with 1.5 T. CONCLUSION: There are several factors that contributed to this important result. First, a greater-than-linear SNR gain was achieved in mouse brain images at 3 T. Second, a reduction in the bandwidth, and the associated increase in repetition time and SNR, produced a dramatic increase in the contrast generated by iron-labeled cells.     

Helium ion beam milling to create a nano-structured domain wall magnetoresistance spin valve

We have fabricated and measured single domain wall magnetoresistance devices with sub-20?nm gap widths using a novel combination of electron beam lithography and helium ion beam milling. The measurement wires and external profile of the spin valve are fabricated by electron beam lithography and lift-off. The critical bridge structure is created using helium ion beam milling, enabling the formation of a thinner gap (and so a narrower domain wall) than that which is possible with electron beam techniques alone. Four-point probe resistance measurements and scanning electron microscopy are used to characterize the milled structures and optimize the He ion dose. Successful operation of the device as a spin valve is demonstrated, with a 0.2% resistance change as the external magnetic field is cycled. The helium ion beam milling efficiency as extracted from electrical resistance measurements is 0.044?atoms/ion, about half the theoretical value. The gap in the device is limited to a maximum of 20?nm with this technique due to sub-surface swelling caused by injected ions which can induce catastrophic failure in the device. The fine patterning capabilities of the helium ion microscope milling technique indicate that sub-5?nm constriction widths could be possible.     

Experimental analysis of a mass storage system

Mass storage systems (MSSs) play a key role in data‐intensive parallel computing. Most contemporary MSSs are implemented as redundant arrays of independent/inexpensive disks (RAID) in which commodity disks are tied together with proprietary controller hardware. The performance of such systems can be difficult to predict because most internal details of the controller behavior are not public. We present a systematic method for empirically evaluating MSS performance by obtaining measurements on a series of RAID configurations of increasing size and complexity. We apply this methodology to a large MSS at Ohio Supercomputer Center that has 16 input/output processors, each connected to four 8 + 1 RAID5 units and provides 128 TB of storage (of which 116.8 TB are usable when formatted). Our methodology permits storage‐system designers to evaluate empirically the performance of their systems with considerable confidence. Although we have carried out our experiments in the context of a specific system, our methodology is applicable to all large MSSs. The measurements obtained using our methods permit application programmers to be aware of the limits to the performance of their codes. Copyright © 2006 John Wiley & Sons, Ltd.     

CONSTRUCTED WETLANDS FOR MINEWATER TREATMENT: ENVIRONMENTAL BENEFITS AND ECOLOGICAL RECOVERY

The ecology of the River Pelenna (in South Wales) was impoverished by polluted discharges from abandoned coal mines. A series of passive constructed wetlands was created in order to treat these discharges and to improve the ecology of the river. A three-year Environment Agency R&D project investigated the performance, environmental benefits and sustainability of the constructed wetlands. It showed that the treatment systems were removing most of the iron contamination. In the reaches downstream from the minewaters, the dissolved-iron concentration quickly dropped below the target level. Invertebrate abundance, trout and riverine bird populations increased in following years. However, occasional overflows from the systems have significantly affected the ecology of one stretch of river. The research work has provided an insight into the potential for ecological recovery associated with future minewater treatment.