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Giorgio Valabrega Giulia Scotto Valentina Tuninetti Arianna Pani Francesco Scaglione 《International journal of molecular sciences》2021,22(8)
Poly(ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for PARP cofactor (NAD+) and trapping PARP on the DNA. In this way, they inhibit single-strand DNA damage repair. These drugs have been approved in recent years for the treatment of ovarian cancer. Although they share some similarities, from the point of view of the chemical structure and pharmacodynamic, pharmacokinetic properties, these drugs also have some substantial differences. These differences may underlie the different safety profiles and activity of PARPi. 相似文献
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In this paper nucleation of superconductivity in films in investigated numerically for all temperatures. Recent predictions of magnetically enhanced superconductivity, even above the critical temperature, are not confirmed. In a limiting case also the surface critical fieldH
c3 was obtained for all temperatures.Dedicated to Professor L. Tewordt on the occasion of his 65th birthday. 相似文献
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Alessia Mariano Irene Bigioni Anna Scotto dAbusco Alessia Baseggio Conrado Simonetta Maina Antonio Francioso Luciana Mosca Mario Fontana 《International journal of molecular sciences》2022,23(1)
Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence of cysteine. Generally, the formation of melanin pigments is a protective response against the damaging effects of UV radiation in skin. However, pheomelanin, like other photosensitizing substances, can trigger, following exposure to UV radiation, photochemical reactions capable of modifying and damaging cellular components. The photoproperties of this natural pigment have been studied by analyzing pheomelanin effect on oxidation/nitration of tyrosine induced by UVB radiation at different pH values and in presence of iron ions. Photoproperties of pheomelanin can be modulated by various experimental conditions, ranging from the photoprotection to the triggering of potentially damaging photochemical reactions. The study of the photomodification of l-Tyrosine in the presence of the natural pigment pheomelanin has a special relevance, since this tyrosine oxidation/nitration pathway can potentially occur in vivo in tissues exposed to sunlight and play a role in the mechanisms of tissue damage induced by UV radiation. 相似文献
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The illumination of overhead lines by a nuclear electromagnetic pulse (NEMP) in presence of a perfectly conducting ground gives rise to a scattering problem leading to phenomenons both studied here in time and frequency domains. This problem is resolved with the help of an integral equation established in space-time domain and making possible (without approximation) the determination of the time dependance of the current induced on each point of the wire structure. Moreover, the passage in frequency domain allows to express a transfer function defined in one point of the excited line, pointing out its spectral characteristics. Results clearly show the insufficiency of the classic transmission line theory concealing some phenomenons which are described here and for which an interpretation is proposed. 相似文献
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William DallariMarco Scotto Marco Allione Elena SamoylovaFrancesca Pignatelli Roberto CingolaniAthanassia Athanassiou Alberto Diaspro 《Microelectronic Engineering》2011,88(12):3466-3469
Three dimensional optical data storage is one of the most promising tools to respond to the always growing demand for high data storage capacity. Here, we focused a femtosecond laser source by means of a confocal microscope onto different transparent recording media. The purpose of the study is to probe the capability of the system to independently address different data layers within the storage medium achieving thus three dimensional data storage. We demonstrated the possibility to write superposed independent layers of data due to either multiphoton excitation or to local optical breakdown and the performances observed in the different types of media used are compared. 相似文献
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The analysis and synthesis of conformal printed antennas on conical surfaces are investigated. The theoretical model is based on the cavity model and the concept of dynamic permittivity to take into account the thickness and the fringing field effects. The originality comes from the use of a computer algebra system to generate the polynomial expression of the zeros of characteristic equations and the analytical relation between the half-angle of the cone and the order of the associated Legendre functions. Fast and accurate expressions for the resonance frequency are given for a rectangular radiating element operating in TM10 and TM01 modes. This model is easily included in a CAD package. Very good agreement is observed between numerical results and experiments 相似文献
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JA Loeppky M Icenogle P Scotto R Robergs H Hinghofer-Szalkay RC Roach 《Canadian Metallurgical Quarterly》1997,107(3):231-239
Maternal smoking increases the risk of the sudden infant death syndrome (SIDS) 2-4-fold. The mechanism is unknown but may be related to hypoxia responses. Recovery from hypoxic apnea by young mammals depends on gasping and bradycardia. We asked whether prenatal nicotine exposure, reported to reduce hypoxic survival in 2 day old rat pups, acted by impairing gasping or bradycardia. Pregnant rats were infused throughout gestation and 1 week postnatally with nicotine tartrate (NIC) 12 mg/kg per day or saline (CON). Maternal plasma nicotine was 134.4 +/- 42 ng/ml, significantly reducing pup body weight. Pups at 3-28 days were exposed to anoxia (97% N2/3% CO2) until gasping ceased, while breathing and heart rate were recorded. NIC and CON groups were not significantly different at any age, in baseline heart rate, respiratory rate, the time course for bradycardia, time to gasp onset, duration of gasping, or number of gasps, although most of these variables declined significantly with age. We conclude that responses to anoxia are not affected by prenatal high-dose nicotine. 相似文献
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A Scotto di Quacquaro F Madonna D Serena C De Vincentiis C Cron L Labrousse C Deville 《Canadian Metallurgical Quarterly》1997,45(10):521-524
Left ventricular rupture is the most frequent cause of death following myocardial infarction after ventricular arrhytmias and cardiogenic shock. Under these circumstances, only a prompt diagnosis and urgent surgical treatment can be lifesaving. A review of the literature is made and a simple surgical technique with GRF glue application is presented. 相似文献
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Electrochemical hysteresis methods are employed to develop experimental potential-pH diagrams for some commercial austenitic and ferritic stainless steels in 3% sodium chloride solutions at room temperature. The results were compared with the electrochemical and the gravimetric behaviour of the single stainless steels in natural sea water. The comparison suggested some considerations about the mechanism of initiation and growth of pitting and crevice corrosion prevailing in natural environment. The higher probability of pits observed in field exposure was correlated to the deposit of a microbiological slime on metal surface that ennobles the free corrosion potentials of passive surfaces up to +400 ÷ +450 m V SCE. The crevice corrosion initiation was in turn attributed to a moderate local acidification originating in conditions of reduced diffusion under the action of passivity current that makes possible pit nucleation which is otherwise unlikely to occur. The pitting growth speeds up the acidification process in the interstice until it causes general corrosion of the walls. 相似文献