关于中国放射源管理的建议

1　放射性废物管理方面( 1 )应当建立一个国家级的废放射源管理战略。此战略应包括过去、现在和将来产生的所有放射性废物。此废物管理战略可以由国家指定的委员会来制订。该委员会可以包括来自主要废物的产生单位、废物管理机构和相应的审管部门的代表。此战略应当涵盖技术选择 (处理和处置 )和基础架构 (废物管理机构和基金 )。( 2 )放射性废物管理 ,包括废密封源管理。要求有专门的技术设施和特别训练的人员。为避免基础结构和人力资源重复设置 ,可以考虑单一的废物管理机构。该机构可设有区域性的分支机构 ,也可以设有专门的部门管理来…     

Book reviews

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Book reviews

     

An NMR‐MOUSE® for Analysis of Thin Objects

A special unilateral NMR sensor has been designed for investigations of thin samples with a thickness of less than 1 mm and of surface effects of polymers. For use with the bar‐magnet NMR‐MOUSE®, the so‐called “crazy coil” is introduced with a low penetration depth. It is a flat meander coil etched on a printed circuit board with wiggles in the conductors. The design of the new coil and FEM simulations of the B ₁ field are presented. Different applications are discussed by means of illustrative examples. They are the detection of surface damage in rubber samples, the swelling and drying of a latex membrane exposed to cyclohexane vapor mimicking a chemical sensor, and the drying of a thin sprayed adhesive layer.

Bar‐magnet NMR‐MOUSE® with crazy coil.     

Contact Pattern Analysis: Simulation of a Laser-Assisted Thermographic Approach

The contact pattern, defined as the area where gear teeth come into contact during their meshing, is a crucial quality feature of gears. If the size and location of the contact pattern are wrong, the gear meshing properties can be significantly affected (e.g., lifetime, noise). Despite several disadvantages, the so-called “paste method” is established as a method to analyse contact patterns. Here, a new measuring approach is examined using the Finite Elements Method (FEM). It is based on the heating-up of one tooth flank with a powerful laser, a subsequent partial transfer of the heat to a meshing tooth of the second gear wheel and finally capturing the heat distribution on that flank as an infrared image shortly afterwards. The thermal image should correspond to the contact pattern of that individual combination of teeth. A numerical analysis shows that at medium- and large-sized gears the achievable temperature increase will be high enough to be detected with modern infrared cameras.     

Microfluidic continuous magnetophoretic protein separation using nanoparticle aggregates

We demonstrate a microfluidic continuous-flow protein separation process in which silica-coated superparamagnetic nanoparticles interact preferentially with hemoglobin in a mixture with bovine serum albumin, and the resulting hemoglobin-nanoparticle aggregates are recovered online using magnetophoresis. We present detailed modeling and analysis of this process yielding quantitative estimates of the recovery of both proteins, validated by experiments. While several previous studies utilize an average particle size in modeling magnetophoretic particle trajectories or process design, in this study we emphasize the importance of accounting for particle size distributions in calculating particle recovery, and therefore in estimating separation efficiency. We combine experimentally measured size distributions of protein-nanoparticle aggregates with simulations of particle trajectories and provide a simple analytical method to calculate the efficiency of separation at various flow speeds, which fully accounts for heterogeneity in particle sizes. Our method can potentially be used for affinity based biomolecular separations at both analytical and preparative scales by exploiting well-established techniques to functionalize nanoparticle surfaces with selective ligands. Further, the modeling methodology presented here may be applied to provide better estimates of particle recovery in a broad range of magnetophoretic separation processes involving heterogeneity in particle sizes.     

Musculoskeletal symptoms among mobile hand-held device users and their relationship to device use: A preliminary study in a Canadian university population

The study aims were, in a population of university students, staff, and faculty (n = 140), to: 1) determine the distribution of seven measures of mobile device use; 2) determine the distribution of musculoskeletal symptoms of the upper extremity, upper back and neck; and 3) assess the relationship between device use and symptoms. 137 of 140 participants (98%) reported using a mobile device. Most participants (84%) reported pain in at least one body part. Right hand pain was most common at the base of the thumb. Significant associations found included time spent internet browsing and pain in the base of the right thumb (odds ratio 2.21, 95% confidence interval 1.02–4.78), and total time spent using a mobile device and pain in the right shoulder (2.55, 1.25–5.21) and neck (2.72, 1.24–5.96). Although this research is preliminary, the observed associations, together with the rising use of these devices, raise concern for heavy users.     

Iron enhances generation of fibrin fibers in human blood: Implications for pathogenesis of stroke

Stroke is associated with the intracerebral formation of fibrin clots which may lead to irreversible brain damage. Thrombolytic therapies employ a variety of natural and/or recombinant plasminogen activators to initiate fibrinolytic degradation of cerebral thrombi. However, such therapies when installed beyond 4‐ to 6‐h window, may fail to achieve the expected outcome. This is due to the hydroxyl radical‐induced modification of fibrin(ogen) molecules rendering them refractory to fibrinolytic degradation, but no cause of the increased free radical generation in stroke was offered. Here, we show by means of electron microscopy that iron ions added to human blood dramatically enhances fibrin fibers formation with thrombin, and significantly delays fibrinolysis during spontaneous clotting of native blood. Iron ions caused the appearance dense matted fibrin deposits, similar, if not identical, to those observed in plasma of patients with stroke. These results may explain a known relationship between thrombotic diseases and the increased body concentrations of free iron and/or hemoglobin derivatives. We conclude that any action resulting in the inhibition of hemostatic abnormalities, as well as in the reduction of body free iron and scavenging of hydroxyl radicals (e.g., by polyphenols) can potentially prevent pathological reactions associated with consequences of stroke. Microsc. Res. Tech. 75:1185–1190, 2012. © 2012 Wiley Periodicals, Inc.     

ATP-regulation of antioxidant properties and phenolics in litchi fruit during browning and pathogen infection process

The impact of energy level on antioxidant properties in relation to pericarp browning and loss of disease resistance of litchi fruit was investigated. Litchi fruits were vacuum-infiltrated with distiled water (control), 1 mM adenosine triphosphate (ATP) and 0.5 mM 2,4-dinitrophenol (DNP) under 75 kPa for 3 min before being inoculated with Peronophythora litchi or not. ATP-treated fruits presented higher activities of antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD) and ascorbate peroxidase (APX). Higher activities of 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, reducing power and contents of phenolic compounds were also observed in ATP-treated fruit during storage. In contrast, DNP treatment lowered the enzymes activities, scavenging ability and the contents of phenolic compounds. Higher levels of antioxidant enzymatic system and non-enzymatic system were observed in P. litchii-inoculated fruits than those in non-inoculated fruits. Application of ATP and DNP exhibited a similar change patterns and effects in inoculated fruits. When related to previously reported ATP levels, the results suggested that ATP levels could regulate the antioxidant system. Sufficient available energy is crucial for inhibiting browning and preventing the loss of disease resistance in harvested litchi fruit.     

金属沾污对超薄栅氧(2. 5nm)特性的影响

采用可控的金属沾污程序 ,最大金属表面浓度控制在 10 1 2 cm- 2数量级 ,来模拟清洗工艺最大可能金属沾污表面浓度 .利用斜坡电流应力和栅注入方式测量本征电荷击穿来评估超薄栅氧特性和金属沾污效应 .研究了金属锆和钽沾污对超薄栅氧完整性的影响 .实验结果表明金属锆沾污对超薄栅氧完整性具有最严重危害 ;金属钽沾污的栅氧发生早期击穿现象 ,而金属铝沾污对超薄栅氧完整性没有明显影响 .