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排序方式: 共有69条查询结果,搜索用时 171 毫秒
1.
U. Sridevi Narayan C. Pradhan B.K.B. Rao C.V. Satyanarayana B.S. Rao 《Catalysis Letters》2002,79(1-4):69-73
The alkylation of benzene with isopropyl alcohol was studied in an integral pressure reactor over silicon substituted aluminophosphate molecular sieves, SAPO-5. The influence of various process parameters such as temperature, pressure, time on stream, weight hourly space velocity, and mole ratio of reactants on cumene yield and selectivity were investigated. The activity of SAPO-5 was compared with that of Hbeta for this reaction under similar conditions and in the same reactor. At pressures higher than atmospheric, almost the theoretical maximum yields of cumene were achieved on this SAPO-5. Among the diisopropyl benzenes formed by the alkylation of cumene, the meta-isomer was found to form in a significant amount followed by the para-isomer. The ortho-isomer with relatively high strain energy of 4.26 kcal/mol was almost negligible. The cumene yield goes through a maximum in the temperature range 498-543 K studied. Cumene selectivity was found to decrease at higher temperatures, higher pressures and lower benzene to isopropanol mole ratios. 相似文献
2.
Golla Narasimha Ayla Sridevi Golla Ramanjaneyulu 《International Journal of Food Properties》2016,19(3):652-661
Aspergillus niger, an isolate of soil contaminated with effluents from cotton ginning mill was grown in Czapek-Dox medium containing sawdust, Triton-X 100 and urea for production of an extracellular β-glucosidase. β-Glucosidase enzyme was purified (86-fold) from culture filtrate of A. niger by employing ammonium sulphate precipitation and gel filtration on sephadex G-75. The molecular mass of the purified enzyme was estimated to be 95 kDa by sodium dodecyl sulphate polyacrylamide gel electrophoresis. The enzyme had an optimal activity on p-nitrophenyl β-D-glucopyranoside at 50°C and pH 5.0. The Km and Vmax of the enzyme on p-nitrophenyl β-D-glucopyranoside at 50°C and pH 5 were 8.0 mM and 166 µmol/min/mg of protein, respectively. The enzyme could hydrolyze cellobiose and lactose but not sucrose. Heavy metals like Hg2+, Al3+, and Ag+ inhibited the activity, whereas Zn2+ and detergents such as Triton-X 100 and Tween-80 increased the activity at 0.01%. The enzyme activity increased in the presence of methanol and ethanol. 相似文献
3.
Ji Yeon Noh Chia-Shan Wu Jennifer A. A. DeLuca Sridevi Devaraj Arul Jayaraman Robert C. Alaniz Xiao-Di Tan Clinton D. Allred Yuxiang Sun 《International journal of molecular sciences》2022,23(4)
Chronic low-grade inflammation is a hallmark of aging, which is now coined as inflamm-aging. Inflamm-aging contributes to many age-associated diseases such as obesity, type 2 diabetes, cardiovascular disease, and inflammatory bowel disease (IBD). We have shown that gut hormone ghrelin, via its receptor growth hormone secretagogue receptor (GHS-R), regulates energy metabolism and inflammation in aging. Emerging evidence suggests that gut microbiome has a critical role in intestinal immunity of the host. To determine whether microbiome is an integral driving force of GHS-R mediated immune-metabolic homeostasis in aging, we assessed the gut microbiome profiles of young and old GHS-R global knockout (KO) mice. While young GHS-R KO mice showed marginal changes in Bacteroidetes and Firmicutes, aged GHS-R KO mice exhibited reduced Bacteroidetes and increased Firmicutes, featuring a disease-susceptible microbiome profile. To further study the role of GHS-R in intestinal inflammation in aging, we induced acute colitis in young and aged GHS-R KO mice using dextran sulfate sodium (DSS). The GHS-R KO mice showed more severe disease activity scores, higher proinflammatory cytokine expression, and decreased expression of tight junction markers. These results suggest that GHS-R plays an important role in microbiome homeostasis and gut inflammation during aging; GHS-R suppression exacerbates intestinal inflammation in aging and increases vulnerability to colitis. Collectively, our finding reveals for the first time that GHS-R is an important regulator of intestinal health in aging; targeting GHS-R may present a novel therapeutic strategy for prevention/treatment of aging leaky gut and inflammatory bowel disease. 相似文献
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5.
Reddithota J. Krupadam P. Sridevi Sistu Sakunthala 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2011,86(3):367-374
BACKGROUND: The removal of endocrine disrupting chemicals (EDCs) from drinking water is of great importance. Chitin isolated from crab shells was used as a biosorbent for removal of three EDCs—benzo(a)antracene, β‐estradiol and bisphenol A—present in contaminated groundwater. Fourier transform infra‐red (FTIR) spectroscopy, porosimetry and scanning electron microscope (SEM) were used for structural elucidation of chitin. Experiments were conducted using batch adsorption mode under different conditions of initial EDCs concentration, solution pH and adsorbent dose. The effect of chitin particle size was also investigated. Batch adsorption data were fitted to Langmuir and Freundlich isotherms and pseudo‐first‐ and second‐order models for kinetic study. RESULTS: The maximum adsorption capacity of chitin by the three EDCs, calculated using the Langmuir equation, ranged from 42.9 to 84 mg g?1. The adsorption of EDCs by chitin was due primarily to electrostatic forces. The measurement of zeta potential indicated that chitin has higher surface charge in alkaline pH, resulting in reduction in removal of EDCs with increasing pH. Complementary to the experimental results molecular simulations were also performed on HyperChem software to understand the adsorption mechanism between chitin and EDCs in aquesous solutions. Chitin was regenerated after washing with methanol/acetic acid (1/3, v/v) and the regeneration process was repeated for 10 cycles, which showed 90% adsorption capacity retained by chitin. CONCLUSIONS: The experimental results suggest that chitin could be employed as an adsorbent in the removal of EDCs from aqueous solutions, and the adsorption potential of used chitin can be recovered by methanol/acetic acid solvent washings. The reusable biosorbent chitin would be cost‐effective and a better option for future water remediation endeavours. Copyright © 2010 Society of Chemical Industry 相似文献
6.
T. R. Vijaybabu T. Ramesh Suman Pandipati Sujit Mishra G Sridevi C Pradeep Raja Rhoda Afriyie Mensah Oisik Das Manjusri Misra Amar Mohanty Karthik Babu NB 《大分子材料与工程》2023,308(7):2300001
The lifespan and the performance of flexible electronic devices and components are affected by the large accumulation of heat, and this problem must be addressed by thermally conductive polymer composite films. Therefore, the need for the development of high thermal conductivity nanocomposites has a strong role in various applications. In this article, the effect of different particle reinforcements such as single and hybrid form, coated and uncoated particles, and chemically treated particles on the thermal conductivity of various polymers are reviewed and the mechanism behind the improvement of the required properties are discussed. Furthermore, the role of manufacturing processes such as injection molding, compression molding, and 3D printing techniques in the production of high thermal conductivity polymer composites is detailed. Finally, the potential for future research is discussed, which can help researchers to work on the thermal properties enhancement for polymeric materials. 相似文献
7.
Structure‐Guided Design of Thiazolidine Derivatives as Mycobacterium tuberculosis Pantothenate Synthetase Inhibitors
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Parthiban Brindha Devi Ganesh Samala Jonnalagadda Padma Sridevi Shalini Saxena Mallika Alvala Elena G. Salina Prof. Dharmarajan Sriram Prof. Perumal Yogeeswari 《ChemMedChem》2014,9(11):2538-2547
The pantothenate biosynthetic pathway is essential for the persistent growth and virulence of Mycobacterium tuberculosis (Mtb) and one of the enzymes in the pathway, pantothenate synthetase (PS, EC: 6.3.2.1), encoded by the panC gene, has become an appropriate target for new therapeutics to treat tuberculosis. Herein, we report nanomolar thiazolidine inhibitors of Mtb PS developed by a rational inhibitor design approach. The thiazolidine compounds were discovered by using energy‐based pharmacophore modelling and subsequent in vitro screening, which resulted in compounds with a half maximal inhibitory concentration (IC50) value of (1.12±0.12) μM . These compounds were subsequently optimised by a combination of modelling and synthetic chemistry. Hit expansion of the lead by chemical synthesis led to an improved inhibitor with an IC50 value of 350 nM and an Mtb minimum inhibitory concentration (MIC) of 1.55 μM . Some of these compounds also showed good activity against dormant Mtb cells. 相似文献
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9.
N. Sridevi Pradnya Vishwe Asmita Prabhune 《Food research international (Ottawa, Ont.)》2009,42(4):516-520
The effect of oral administration of the immobilized bile salt hydrolase enzyme on serum cholesterol, triglyceride, high density lipoprotein levels and its application in the therapeutic treatment of hypercholesteremia was assessed. Culture conditions were optimized for the production of bile salt hydrolase, which resulted in 2.9-fold enhancement in activity. Bile salt hydrolase (BSH; E.C.3.5.1.24) was isolated from Lactobacillus buchneri ATCC 4005 and immobilized in 0.5% gellan gum gel. The immobilized enzyme was orally delivered in wistar rats, induced with hypercholesteremia by triton X-100. The serum cholesterol and triglycerides were reduced by 50% and 15%, respectively, in the group fed with immobilized enzyme 10 IU/kg dose whereas administration of 20 IU/kg immobilized enzyme resulted in reduction of serum cholesterol by 58% and triglycerides by 45%, respectively. The results indicate that bile salt hydrolase has potential cholesterol lowering property and oral administration of the immobilized enzyme is an alternative pharmacological approach to reduce serum cholesterol levels. 相似文献
10.
Multimedia Tools and Applications - In this paper an efficient implementation of decision feed back equalizer (DFE) is carried out using novel memory less distributed arithmetic (NMLDA) filter. In... 相似文献