Cost-Efficient SHA Hardware Accelerators

This paper presents a new set of techniques for hardware implementations of Secure Hash Algorithm (SHA) hash functions. These techniques consist mostly in operation rescheduling and hardware reutilization, therefore, significantly decreasing the critical path and required area. Throughputs from 1.3 Gbit/s to 1.8 Gbit/s were obtained for the SHA implementations on a Xilinx VIRTEX II Pro. Compared to commercial cores and previously published research, these figures correspond to an improvement in throughput/slice in the range of 29% to 59% for SHA-1 and 54% to 100% for SHA-2. Experimental results on hybrid hardware/software implementations of the SHA cores, have shown speedups up to 150 times for the proposed cores, compared to pure software implementations.      

Two-year results after lung volume reduction surgery in alpha1-antitrypsin deficiency versus smoker's emphysema

Lung volume reduction surgery (LVRS) improves exercise capacity and relieves dyspnoea in patients with smoker's emphysema (SE). It is unclear, however, whether LVRS similarly improves lung function in alpha1-antitrypsin-deficiency emphysema (alpha1 E). To address this question, this study prospectively compared the intermediate-term functional outcome in 12 consecutive patients with advanced alpha1E and 18 patients with SE who underwent bilateral LVRS. Before surgery there were no statistically significant differences between the two groups in the six-minute walking distance, dyspnoea score, respiratory mechanics or lung function data, except for the forced expiratory volume in one second, which was lower in the deficient group (24 versus 31% of the predicted value; p<0.05). In both groups, bilateral LRVS produced significant improvements in dyspnoea, the six-minute walking distance, lung function and respiratory mechanics. In the alpha1E group, the functional data, with the exception of the six-minute walking distance, returned to baseline at 6-12 months postoperation and showed further deterioration at 24 months. The functional status of the SE group remained significantly improved over this period. In conclusion, the functional improvements resulting from bilateral lung volume reduction surgery are sustained for at least 2 yrs in most patients with smoker's emphysema, but this type of surgery offers only short-term benefits for most patients with alpha1E.     

An Engineered sgsh Mutant Zebrafish Recapitulates Molecular and Behavioural Pathobiology of Sanfilippo Syndrome A/MPS IIIA

Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan sulfate glycosaminoglycan (HS GAG) and its accumulation in tissues. MPS IIIA represents a significant proportion of childhood dementias. This condition generally leads to patient death in the teenage years, yet no effective therapy exists for MPS IIIA and a complete understanding of the mechanisms of MPS IIIA pathogenesis is lacking. Here, we employ targeted CRISPR/Cas9 mutagenesis to generate a model of MPS IIIA in the zebrafish, a model organism with strong genetic tractability and amenity for high-throughput screening. The sgsh^Δex5−6 zebrafish mutant exhibits a complete absence of Sgsh enzymatic activity, leading to progressive accumulation of HS degradation products with age. sgsh^Δex5−6 zebrafish faithfully recapitulate diverse CNS-specific features of MPS IIIA, including neuronal lysosomal overabundance, complex behavioural phenotypes, and profound, lifelong neuroinflammation. We further demonstrate that neuroinflammation in sgsh^Δex5−6 zebrafish is largely dependent on interleukin-1β and can be attenuated via the pharmacological inhibition of Caspase-1, which partially rescues behavioural abnormalities in sgsh^Δex5−6 mutant larvae in a context-dependent manner. We expect the sgsh^Δex5−6 zebrafish mutant to be a valuable resource in gaining a better understanding of MPS IIIA pathobiology towards the development of timely and effective therapeutic interventions.     

Single-channel demodulator and Hartley transform in MRI

A single-channel alternative detection system for magnetic resonance imaging and spectroscopy experiments is presented. After the phase error identification, which is realized through a simple method, one can correct the reconstructed image and discriminate between positive and negative frequencies without any loss of the S/N ratio. Since there is only one channel, that is a real signal, it is possible to use the Hartley instead of the Fourier transform. The former is faster and requires less storage memory.     

A formally specified ontology management API as a registry for ubiquitous computing systems

Recently, several standards have emerged for ontology markup languages that can be used to formalize all kinds of knowledge. However, there are no widely accepted standards yet that define APIs to manage ontological data. Processing ontological information still suffers from the heterogeneity imposed by the plethora of available ontology management systems. Moreover, ubiquitous computing environments usually comprise software components written in a variety of different programming languages, which makes it particularly difficult to establish a common ontology management API with programming language agnostic semantics. We implemented an ontological Knowledge Base Server, which can expose the functionality of arbitrary off-the-shelf ontology management systems via a formally specified and well defined API. A case study was carried out in order to demonstrate the feasibility of our approach to use a formally specified ontology management API to implement a registry for ubiquitous computing systems.     

: towards the modeling, design, control and execution of ETL processes

Extraction-Transformation-loading (ETL) tools are pieces of software responsible for the extraction of data from several sources, their cleansing, customization and insertion into a data warehouse. Literature and personal experience have guided us to conclude that the problems concerning the ETL tools are primarily problems of complexity, usability and price. To deal with these problems we provide a uniform metamodel for ETL processes, covering the aspects of data warehouse architecture, activity modeling, contingency treatment and quality management. The ETL tool we have developed, namely , is capable of modeling and executing practical ETL scenarios by providing explicit primitives for the capturing of common tasks. provides three ways to describe an ETL scenario: a graphical point-and-click front end and two declarative languages: XADL (an XML variant), which is more verbose and easy to read and SADL (an SQL-like language) which has a quite compact syntax and is, thus, easier for authoring.     

Establishing the relevancy of the bookkeeping libraries to thefunctional testing of computer implementations

We address issues related to the definition of faults, errors and failures and their separability, and attribution to the different development processes of computing systems. In particular, we deal with historical databases, which presumably contain certain data (i.e., test failure data) and describe the methodology that can be used to analyze the database and obtain the pertinent information. The validation method may be of particular importance, especially when information from the database needs to be extrapolated for a purpose other than the one for which the database was developed. Our methodology was used to evaluate the historical data collected during the development of the IBM 4381 and 9370 family of computers, and to extrapolate the faults found during the function testing     

Symbiosis with artificial intelligence via the prism of law,robots, and society

The rapid advances in Artificial Intelligence and Robotics will have a profound impact on society as they will interfere with the people and their interactions. Intelligent autonomous robots, independent if they are humanoid/anthropomorphic or not, will have a physical presence, make autonomous decisions, and interact with all stakeholders in the society, in yet unforeseen manners. The symbiosis with such sophisticated robots may lead to a fundamental civilizational shift, with far-reaching effects as philosophical, legal, and societal questions on consciousness, citizenship, rights, and legal entity of robots are raised. The aim of this work is to understand the broad scope of potential issues pertaining to law and society through the investigation of the interplay of law, robots, and society via different angles such as law, social, economic, gender, and ethical perspectives. The results make it evident that in an era of symbiosis with intelligent autonomous robots, the law systems, as well as society, are not prepared for their prevalence. Therefore, it is now the time to start a multi-disciplinary stakeholder discussion and derive the necessary policies, frameworks, and roadmaps for the most eminent issues.

     

Star-like auto-configurable layouts of variable radius for visualizing and exploring RDF/S ontologies

The visualization of ontologies is a challenging task especially if they are large. In this paper we propose a visualization approach which is based on star-like graphs of variable radius which enables users to gradually explore and navigate through the entire ontology without overloading them. The star-like graphs are visualized using a Force Directed Placement algorithm (FDP) specially suited for RDF schemas whose configuration parameters can be adjusted interactively by the end-user via an intuitive on-screen tool bar. In addition, and since each star-like graph exhibits different graph features, we propose a novel automatic configuration method for the FDP algorithm parameters that is based on a number of quality metrics (area density and verticality of subclass hierarchies) and corresponding corrective actions. The experimental evaluation showed the quality of the yielded layout is significantly improved and the proposed approach is acceptably fast for real-time exploration. The user study showed that users prefer these views and perform various very common tasks faster.