医用微型全量分析系统中的酶生物传感器研究

酶生物传感器由于其对被分析物具有高度的选择性,成为解决μTAS(微型全量分析系统)中,复杂体系下的多种组分同时测定问题一个有效方法.以基于葡萄糖氧化酶的葡萄糖传感器为例,研究了酶生物传感器对被分析物的选择特性,实验证明,酶生物传感器完全适用于μTAS 中多种组分同时测定的用途.     

Eradication of Helicobacter pylori in patients with end-stage renal disease undergoing dialysis treatment

The aim of the present study was to examine the efficacy and safety of combination therapy with amoxicillin (AMPC), lansoprazole, and plaunotol for the eradication of H. pylori in dialysis patients. The subjects consisted of 15 dialysis patients (10 men and 5 women, mean age of 56 +/- 2.4 years) in whom H. pylori was found in the stomach. H. pylori status was evaluated by histology, culture and rapid urease test with biopsy specimens of the gastric mucosa. The patients were treated with AMPC 500 mg once a day for 3 weeks, lansoprazole 30 mg once a day for 8 weeks and plaunotol 80 mg three times a day for 24 weeks. In addition, the concentrations of serum gastrin and gastric juice ammonia were measured. Fourteen patients completed the treatment schedule, while one discontinued treatment because of nausea and diarrhea. Among the 14 patients, H. pylori was eradicated in 11 without any side effects (eradication rate 78.6%). Concentrations of gastric juice ammonia and serum gastrin were reduced significantly in patients who became H. pylori-negative. The present study indicates that combination therapy with AMPC, lansoprazole and plaunotol is safe and efficient for the eradication of H. pylori in dialysis patients. The results also suggested that elevated concentrations of gastric juice ammonia and serum gastrin in dialysis patients can be attributed, at least in part, to H. pylori infection.     

Photonic crystal line defect waveguide directional coupler

A three-port directional coupler based on photonic crystal line defect waveguides is demonstrated. The directional coupler has only a 21 μm long coupling region. Wavelength-selecting operation around 1.5 μm wavelength was confirmed     

Multimode Si-wire waveguides for integrated optical delay lines

A delay line of multimode Si-wire waveguide folded with 45deg mirror bends is described. A 17 cm waveguide with a core size of 1times3 mum² was integrated in an area of 0.85 mm². The waveguide generated a constant group delay of 2 ns in the entire C-band with a typical optical loss of 14 dB. It also exhibited an error-free operation for 10 Gbit/s optical data signals.     

Ultrahigh resolution soft x-ray emission spectrometer at BL07LSU in SPring-8

An extremely high resolution flat field type slit less soft x-ray emission spectrometer has been designed and constructed for the long undulator beamline BL07LSU in SPring-8. By optimizing the ruling parameters of two cylindrical gratings, a high energy resolution ΔE < 100 meV and/or an E∕ΔE ~ 10 000 are expected for the energy range of 350 eV - 750 eV taking into account the broadening by the spatial resolution (25 μm) of a CCD detector. A coma-free operation mode proposed by Strocov et al., is also applied to eliminate both defocus and coma aberrations. The spectrometer demonstrated experimentally that E/ΔE = 10 050 and 8046 for N 1s (402.1 eV) and Mn 2p (641.8 eV) edges, respectively.     

Gastric adenocarcinoma producing neuron-specific enolase

Analysis of H-, K- and N-ras genes for point mutations by PCR-SSCP and direct sequencing of 46 oral SCCs that were previously analyzed for p53 mutations revealed that 9 (20%) had point mutations in either the H-ras or the N-ras. A novel mutation at codon 59 (GCC-ACC) of H-ras thus far reported only in v-H-ras of Harvey murine sarcoma virus was observed in a tumor of the cheek. Majority (8/9) of these mutations were observed in H-ras, one in N-ras and none in K-ras. This study indicated that the ras gene mutation was relatively high in oral cancers associated with tobacco chewing and the ras and p53 mutational events seem to be independent and mutually exclusive.     

Feasibility Study on Estimation of Permittivity Distribution by using Genetic Algorithm and Finite Element Analysis

We have investigated a measurement system for permittivity distribution based on the measured capacitance using a pair of large distance electrodes with shield and additional electrodes. However, the estimation of the permittivity distribution has not yet been established. In the paper, we propose a new numerical estimation method based on genetic algorithm (GA) and finite element method (FEM). The gene in the present GA method will have the information on such parameters as the location, radius and relative permittivity of a dielectric. The estimation of capacitance was done by using FEM with the numerical mesh data generated by the information on the gene. We also describe the feasibility of estimation of permittivity distribution using GA and FEM. Copyright © 2008 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.     

An ultralow-power-consumption, high-speed, GaAs 256/258dual-modulus prescaler IC

A GaAs divide-by-256/258 dual-modulus static prescaler is described. The prescaler has a pulse-swallow counter-type architecture and quasi-differential switch flip-flops as its basic circuit architecture. For the input buffer circuit, a circuit called a source-coupled push-pull circuit has been developed that can generate high-frequency complementary signals from a single-phase signal at a low supply voltage. This IC operates at up to 14.5 GHz with a power consumption of 22 mW. The power consumption is less than 1/50 of the previously reported prescalers that can operate above 10 GHz     

Development of an Autonomous Mobile Robot with Several Sensors using Neuro‐Fuzzy Control Based on Server/Client Model

The purpose of this paper is to detail the development of an autonomous mobile robot and a control support system. The robot has five infrared sensors and three ultrasonic sensors to enable it to follow a ‘ guide person’ with an infrared ray transmitter. The robot will follow the infrared rays emitted by a transmitter with the guide person, and move to the destination. The control system has been developed by the network technology based on server/client model. The advanced control strategy for the autonomous mobile robot is carried out with a high‐speed host server computer connected through the TCP/IP network. Therefore, it is enough for the CPU of the robot to be of low speed. In this paper, the autonomous mobile robot system and the control system using the server/client model are described. Copyright © 2008 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.