Adjuvant intra-arterial chemotherapy with gastrin receptor antagonist after hepatic resection in colorectal cancer metastasis

The aim of this study was to determine whether chemo-endocrine therapy after the resection of liver metastasis from colorectal cancer would prevent recurrence in the remnant liver and prolong survival. Eleven colorectal cancer patients underwent hepatic resection for liver metastasis. Subsequently, they were administered Proglumide gastrin antagonist 1,200 mg/day + 5'-DFUR 800 mg/day for 2 years. In seven of them, MMC 6-10 mg and ADM 20 mg were infused intra-arterially every two weeks alternately for one year. In four of them, 5-FU 250 mg/day was infused for seven days continuously intra-arterially every two weeks for one year. Recurrence in the remnant liver occurred in four of 11 patients. All of these patients underwent repeated hepatectomy. The mean disease-free survival in the remnant liver was 37 months and the five-year survival rate was 91%. These results indicate that intra-arterial chemotherapy with gastrin receptor antagonist might be effective for adjuvant therapy in patients with resectable liver metastasis from colorectal cancer.     

Electrical properties of D-T gas from 20 to 26 K

The dielectric constants and electrical conductivities of D-T gas at 20, 23, and 25 K are measured at 1592 Hz from 3 to 200 Vm² mol^?1. Tritium concentrations are 0.9, 8.8, and 98.3%. Both electrical quantities increase with density ans saturate above 400 mol m^?3. The gas is a soft dielectric, with an electrical conductivity as high as $\text{300 × 10}{}^{\mathrm{?9}}\text{Ω}\text{m}{}^{\mathrm{?1}}$. The saturated vapour conducts as well as the liquid beneath it. The total charge desity in pure tritium gas is about 10¹² mol^?1. Most electrons may react to form tritide ions, but the remaining electrons still carry most of the current.     

NMR lineshapes in solid tritium and deuterium-tritium

We report on the NMR free induction decays (FID) from solid tritium (T₂), deuterium-tritium (D-T), and H₂, HD and D₂ containing 2% tritium. The FID in pure components is typically a beat decay for spin concentrations >30%, an exponential for spin concentrations <10%, and a Gaussian or Gaussian-exponential for spin concentrations in between. In mixtures of DT or HD, the deuteron FID is a Gaussian-exponential while the T or H FID is typically a beat decay or Gaussian depending on temperature. The linewidth is shown to consist mostly of intermolecular and intramolecular contributions, with a small component resulting from unpaired hydrogen atoms created by the tritium radioactivity.     

Anomalous vapour pressure over liquid D-T

The presence of a few tenths mol % helium in hydrogen causes anomalous vapour pressures as high as 10 kPa. This effect is caused by the combination of a small cold cell, a single, long fill tube, and the insolubility of helium in liquid hydrogen. This effect is important in the handling of deuterium-tritium, as radioactive decay produces He³.     

Circularly polarized dielectric-loaded planar antenna excited bythe parallel feeding waveguide network

A new receiving planar array antenna for DBS (direct broadcasting satellite) is proposed. The element antenna is a short waveguide aperture mounted in the ground plane, loaded with a dielectric and polarizers, and excited through its side wall by another feeding rectangular waveguide. The gain of the element antenna loaded with a dielectric is so high that the grating lobes can be reduced sufficiently even if the element spacing in the array is wider than the wavelength in free space. Therefore we can reduce the number of the array elements, and parallel feeding by the low loss waveguide network can be feasible to provide a planar array antenna. This paper describes the experimental results of several kinds of the circularly polarized dielectric-loaded element antennas and the planar antennas fed by the waveguide network. In the 12 GHz band the planar antenna with 64-element radiators has a maximum gain of 31.9 dBi with an aperture efficiency of 94.7%, the 1 dB-down frequency bandwidth of the gain is about 800 MHz (6.7% for a center frequency of 11.85 GHz), and the frequency bandwidth of the axial ratio is less than 1 dB of 850 MHz (7.2%)     

Vehicle control algorithms for cooperative driving with automated vehicles and intervehicle communications

Describes the technologies of cooperative driving with automated vehicles and intervehicle communications in the Demo 2000 cooperative driving. Cooperative driving, aiming at the compatibility of safety and efficiency of road traffic, means that automated vehicles drive by forming a flexible platoon over a couple of lanes with a short intervehicle distance while performing lane changing, merging, and leaving the platoon. The vehicles for the demonstration are equipped with automated lateral and longitudinal control functions with localization data by the differential global positioning system (DGPS) and the intervehicle communication function with 5.8-GHz dedicated short range communication (DSRC) designed for the dedicated use in the demonstration. In order to show the feasibility and potential of the technologies, the demonstration was held in November 2000, on a test track with five automated vehicles. The scenario included stop and go, platooning, merging, and obstacle avoidance.     

Development of fructosyl amine oxidase specific to fructosyl valine by site-directed mutagenesis

Docking models of fructosyl amine oxidase (FAOD) from the marineyeast Pichia N1-1 (N1-1 FAOD) with the substrates fructosylvaline (f-Val) and fructosyl-N-lysine (f-Lys) were producedusing three-dimensional protein model as reported previously(Miura et al., 2006, Biotechnol. Lett., 28, 1895-1900). Theresidues involved in recognition of substrates were proposed,particularly Asn354, which interacts closely with f-Lys, butnot with f-Val. Substitution of Asn354 to histidine and lysinesimultaneously resulted in an increase in activity of f-valand a decrease in activity of f-Lys and thus, increasing thespecificity for f-Val from 13- to 19-fold. In addition to creatingtwo mutant FAODs with great potential for the measurement ofglycated hemoglobin, we have provided the first structural modelof substrate binding with eukaryotic FAOD, which is expectedto contribute to further investigation of FAOD.     

Nanocrystalline diamond growth in a surface-wave plasma

A surface-wave excited plasma is exploited in a diamond growth process by microwave plasma chemical vapor deposition method. Nanocrystalline diamond films with smooth surfaces are obtained from the plasma. As well as characterizing the deposited diamond films, the electron density and the electron temperature of the plasma are determined by using double-probe measurements. The plasma diagnosis reveals low electron temperatures of 2–3 eV in the process region, which is a distinctive characteristic of the surface-wave plasma. The low electron temperature is essential for the continuous re-nucleation of diamond in a hydrogen-rich plasma during the nanocrystalline diamond growth for a wide range of substrate temperature from under 100 to over 700 ^°C.     

Syntheses and preventive effects of analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats

Analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity.