Analyzing execution traces: critical-path analysis and distance analysis

International Journal on Software Tools for Technology Transfer - System designers make trade-offs between metrics of interest such as execution time, functional quality and cost to create a...     

Resource-efficient routing and scheduling of time-constrained streaming communication on networks-on-chip

Network-on-chip-based multiprocessor systems-on-chip are considered as future embedded systems platforms. One of the steps in mapping an application onto such a parallel platform involves scheduling the communication on the network-on-chip. This paper presents different scheduling strategies that minimize resource usage by exploiting all scheduling freedom offered by networks-on-chip. It also introduces a technique to take the dynamism in applications into account when scheduling the communication of an application on the network-on-chip while minimizing the resource usage. Our experiments show that resource-utilization is improved when compared to existing techniques.     

Model demonstrating the potential for coupled nitrification denitrification in soil aggregates

A model of reactive, multi-species diffusion has been developed to describe N transformations in spherical soil aggregates, emphasizing the effects of irrigation with reclaimed wastewater. Oxygen demand for respiratory activity has been shown to promote the establishment of anaerobic conditions. Aggregate size and soil respiration rate were identified as the most significant parameters governing the existence and extent of the anaerobic volume in aggregates. The inclusion of kinetic models describing mineralization, nitrification, and denitrification facilitated the investigation of coupled nitrification/denitrification (CND), subject to O2 availability. N-transformations are shown to be affected by effluent-borne NH4+-N content, in addition to elevated BOD and pH levels. Their incremental contribution to O2 availability has been found to be secondary to respiratory activity. At the aggregate level, significant differences between apparent and gross rates of N-transformations were predicted (e.g., NH4+ oxidation and N2 formation), resulting from diffusive constraints due to aggregate size. With increasing anaerobic volume, the effective nitrification rate determined at the aggregates level decreases until its contribution to nitrification is negligible. It was found that the nitrification process was predominantly limited to aggregates <0.25 cm. Assuming that nitrification is the main source for NO3- formation, denitrification efficiency is predicted to peak in medium-sized aggregates, where aerobic and anaerobic conditions coexist, supporting CND. In effluent-irrigated soils, the predicted NO2- formation rate in small aggregates is enhanced when compared to freshwater-irrigated soils. The difference vanishes with increasing aggregate size as anaerobic NO2- consumption exceeds aerobic NO2- formation due to the coupling of nitrification and denitrification.     

情人节の魔法诱惑

魔术是个千变万化的游戏，随时给人以出乎意料的结果，给生活注入了不少快乐元素。其实魔术也是交朋友、泡马子的好方式，如果在聚会、约会时随手变个魔术，会让MM觉得你有几分神秘感，增加把妹成功的几率哦!     

Imaging of metal-coated biological samples by scanning tunneling microscopy

A method for imaging biological samples by scanning tunneling microscopy (STM) is presented. There are two main difficulties in imaging biological samples by STM: (1) the low conductivity of biological material and (2) finding a method of reliably depositing the sample on a flat conducting surface. The first of these difficulties was solved by coating the samples with a thin film of platinum-carbon. The deposition problem was solved by a method similar to a procedure used to deposit biological molecules onto field ion microscope (FIM) tips. STM images of bacteriophage T7 and filamentous phage fd are shown. The substrate on which the samples were absorbed was atomically flat gold. The images do not show molecular detail due to the metal coating, but the gross dimensions and morphology are correct for each type of virus. Also, the surface density of virus particles increases and decreases in the way expected when the conditions of deposition are changed. These methods allow reliable and reproducible STM imaging of biological samples.     

Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation

Efficient and safe drug delivery across the blood‐brain barrier (BBB) remains one of the major challenges of biomedical and (nano‐) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)‐based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation. Upon exposure to transcranial ultrasound pulses, USPIO‐MB are destroyed, resulting in acoustic forces inducing vessel permeability. At the same time, USPIO are released from the MB shell, they extravasate across the permeabilized BBB and they accumulate in extravascular brain tissue, thereby providing non‐invasive R ₂*‐based magnetic resonance imaging information on the extent of BBB opening. Quantitative changes in R ₂* relaxometry are in good agreement with 2D and 3D microscopy results on the extravascular deposition of the macromolecular model drug fluorescein isothiocyanate (FITC)‐dextran into the brain. Such theranostic materials and methods are considered to be useful for mediating and monitoring drug delivery across the BBB and for enabling safe and efficient treatment of CNS disorders.     

Iron Oxide‐Labeled Collagen Scaffolds for Non‐Invasive MR Imaging in Tissue Engineering

Non‐invasive imaging holds significant potential for implementation in tissue engineering. It can be used to monitor the localization and function of tissue‐engineered implants, as well as their resorption and remodelling. Thus far, however, the vast majority of effort in this area of research have focused on the use of ultrasmall super‐paramagnetic iron oxide (USPIO) nanoparticle‐labeled cells, colonizing the scaffolds, to indirectly image the implant material. Reasoning that directly labeling scaffold materials might be more beneficial (enabling imaging also in the case of non‐cellularized implants), more informative (enabling the non‐invasive visualization and quantification of scaffold degradation), and easier to translate into the clinic (cell‐free materials are less complex from a regulatory point‐of‐view), three different types of USPIO nanoparticles are prepared and incorporated both passively and actively (via chemical conjugation; during collagen crosslinking) into collagen‐based scaffold materials. The amount of USPIO incorporated into the scaffolds is optimized, and correlated with MR signal intensity, showing that the labeled scaffolds are highly biocompatible, and that scaffold degradation can be visualized using MRI. This provides an initial proof‐of‐principle for the in vivo visualization of the scaffolds. Consequently, USPIO‐labeled scaffold materials seem to be highly suitable for image‐guided tissue engineering applications.     

金属沾污对超薄栅氧(2. 5nm)特性的影响

采用可控的金属沾污程序 ,最大金属表面浓度控制在 10 1 2 cm- 2数量级 ,来模拟清洗工艺最大可能金属沾污表面浓度 .利用斜坡电流应力和栅注入方式测量本征电荷击穿来评估超薄栅氧特性和金属沾污效应 .研究了金属锆和钽沾污对超薄栅氧完整性的影响 .实验结果表明金属锆沾污对超薄栅氧完整性具有最严重危害 ;金属钽沾污的栅氧发生早期击穿现象 ,而金属铝沾污对超薄栅氧完整性没有明显影响 .     

Efficacy of alpha biofeedback training in elevating mood.

Tested the hypothesis that alpha brain wave feedback training elevates mood, using 3 groups of 8 Ss each: Group I underwent training, Group 2 kept the alpha feedback signal off, and Group 3 named titles of tunes. Ss completed a perceived success questionnaire and the Multiple Affect Adjective Checklist. The hypothesis was not supported by the results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)