Transfer Learning of BCI Using CUR Algorithm

The brain computer interface (BCI) are used in many applications including medical, environment, education, economy, and social fields. In order to have a high performing BCI classification, the training set must contain variations of high quality subjects which are discriminative. Variations will also drive transferability of training data for generalization purposes. However, if the test subject is unique from the training set variations, BCI performance may suffer. Previously, this problem was solved by introducing transfer learning in the context of spatial filtering on small training set by creating high quality variations within training subjects. In this study however, it was discovered that transfer learning can also be used to compress the training data into an optimal compact size while improving training data performance. The transfer learning framework proposed was on motor imagery BCI-EEG using CUR matrix decomposition algorithm which decomposes data into two components; C and UR which is each subject’s EEG signal and common matrix derived from historical EEG data, respectively. The method is considered transfer learning process because it utilizes historical data as common matrix for the classification purposes. This framework is implemented in the BCI system along with Common Spatial Pattern (CSP) as features extractor and Extreme Learning Machine (ELM) as classifier and this combination exhibits an increase of accuracy to up to 26% with 83% training database compression.

     

A Metaheuristic Technique for Cluster-Based Feature Selection of DNA Methylation Data for Cancer

Epigenetics is the study of phenotypic variations that do not alter DNA sequences. Cancer epigenetics has grown rapidly over the past few years as epigenetic alterations exist in all human cancers. One of these alterations is DNA methylation; an epigenetic process that regulates gene expression and often occurs at tumor suppressor gene loci in cancer. Therefore, studying this methylation process may shed light on different gene functions that cannot otherwise be interpreted using the changes that occur in DNA sequences. Currently, microarray technologies; such as Illumina Infinium BeadChip assays; are used to study DNA methylation at an extremely large number of varying loci. At each DNA methylation site, a beta value (β) is used to reflect the methylation intensity. Therefore, clustering this data from various types of cancers may lead to the discovery of large partitions that can help objectively classify different types of cancers as well as identify the relevant loci without user bias. This study proposed a Nested Big Data Clustering Genetic Algorithm (NBDC-GA); a novel evolutionary metaheuristic technique that can perform cluster-based feature selection based on the DNA methylation sites. The efficacy of the NBDC-GA was tested using real-world data sets retrieved from The Cancer Genome Atlas (TCGA); a cancer genomics program created by the National Cancer Institute (NCI) and the National Human Genome Research Institute. The performance of the NBDC-GA was then compared with that of a recently developed metaheuristic Immuno-Genetic Algorithm (IGA) that was tested using the same data sets. The NBDC-GA outperformed the IGA in terms of convergence performance. Furthermore, the NBDC-GA produced a more robust clustering configuration while simultaneously decreasing the dimensionality of features to a maximum of 67% and of 94.5% for individual cancer type and collective cancer, respectively. The proposed NBDC-GA was also able to identify two chromosomes with highly contrasting DNA methylations activities that were previously linked to cancer.