In this paper, an approach has been made to produce a compressed audio without losing any information. The proposed scheme is fabricated with the help of dynamic cluster quantization followed by Burrows Wheeler Transform (BWT) and Huffman coding. The encoding algorithm has been designed in two phases, i.e., dynamic cluster selection (of sampled audio) followed by dynamic bit selection for determining quantization level of individual cluster. Quantization level of each cluster is selected dynamically based on mean square quantization error (MSQE). Bit stream is further compressed by applying Burrows Wheeler Transform (BWT) and Huffman code respectively. Experimental results are supported with current state-of-the-art in audio quality analysis (like statistical parameters (compression ratio, space savings, SNR, PSNR) along with other parameters (encoding time, decoding time, Mean Opinion Score (MOS) and entropy) and compared with other existing techniques.
Background: Breast cancer is the most common cancer in women globally, and diagnosing it early and finding potential drug candidates against multi-drug resistant metastatic breast cancers provide the possibilities of better treatment and extending life. Methods: The current study aimed to evaluate the synergistic anti-metastatic activity of Curcumin (Cur) and Paclitaxel (Pacli) individually, the combination of Curcumin–Paclitaxel (CP), and also in conjugation with gold nanoparticles (AuNP–Curcumin (Au-C), AuNP–Paclitaxel (Au-P), and AuNP–Curcumin–Paclitaxel (Au-CP)) in various in vitro and in vivo models. Results: The results from combination treatments of CP and Au-CP demonstrated excellent synergistic cytotoxic effects in triple-negative breast cancer cell lines (MDA MB 231 and 4T1) in in vitro and in vivo mouse models. Detailed mechanistic studies were performed that reveal that the anti-cancer effects were associated with the downregulation of the expression of VEGF, CYCLIN-D1, and STAT-3 genes and upregulation of the apoptotic Caspase-9 gene. The group of mice that received CP combination therapy (with and without gold nanoparticles) showed a significant reduction in the size of tumor when compared to the Pacli alone treatment and control groups. Conclusions: Together, the results suggest that the delivery of gold conjugated Au-CP formulations may help in modulating the outcomes of chemotherapy. The present study is well supported with observations from cell-based assays, molecular and histopathological analyses. 相似文献
Iron (III) oxide, Fe2O3, nanoparticles of approximately 40 nm diameter were synthesized by sol–gel method and their nitrogen dioxide adsorption and desorption kinetics were investigated by custom fabricated gas sensor unit. The morphology and crystal structure of Fe2O3 nanoparticles were studied by scanning electron microscopy (SEM), field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) respectively. The roughness of film surface was investigated by atomic force microscopy (AFM). Relative sensitivity of Fe2O3 nanoparticles for NO2 sensor was determined by electrical resistance measurements. Our reproducible experimental results show that Fe2O3 nanoparticles have a great potential for nitrogen dioxide sensing applications operating at a temperature of 200 °C. 相似文献
Homothymine oligonucleotides with a single 5‐mercuricytosine or 5‐mercuriuracil residue at their termini have been synthesized and their capacity to form triplexes has been examined with an extensive array of double‐helical targets. UV and circular dichroism (CD) melting experiments revealed the formation and thermal denaturation of pyrimidine ? purine*pyrimidine‐type triple helices with all oligonucleotide combinations studied. Nearly all triplexes were destabilized upon mercuration of the 3′‐terminal residue of the triplex‐forming oligonucleotide, in all likelihood due to competing intramolecular HgII‐mediated base pairing. Two exceptions from this general pattern were, however, observed: 5‐mercuricytosine was stabilizing when placed opposite to a T ? A or A ? T base pair. The stabilization was further amplified in the presence of 2‐mercaptoethanol (but not hexanethiol, thiophenol or cysteine), suggesting a stabilizing interaction other than HgII‐mediated base pairing. 相似文献
A novel solvent extraction separation method has been developed for the determination of gold in real samples. It involves selective and quantitative extraction of gold by N-n-octylaniline, a high molecular weight amine (HMWA), in xylene from aqueous sodium malonate medium at pH 1.0. The effects of concentration of malonate, extractant, metal ion, and pH and of various diluents, stripping agents and other substances on the quantitative extraction of gold have been assessed. The applicability of the method to binary mixtures, synthetic mixtures, alloys and pharmaceutical samples is discussed. 相似文献
This paper provides an alternative test procedure for the problem oftesting of normal mean for one sided alternative when the variance is known in case of costly trials. The proposed test is based on a sampling scheme which we call 'continuous adaptive design'. Some exact andasymptotic results related to the test and design are studied. 相似文献
The aim of this report is to build a portable solar thermal bank based on a Scheffler reflector that is capable of boiling-type cooking using HITEC as a thermal storage material. This report reviews the problems related to solar cooking and evaluates the novel layout of a portable solar thermal bank which includes a daily thermal storage vessel. This stove is in the shape of a cylindrical container filled with phase-changing latent heat storage material. Inside the container, we provide a small gap taking into account the volumetric expansion of the phase change material (PCM) during the melting process. The solar thermal bank is charged in the sun. It is placed directly for a few hours under the focus of a Scheffler reflector, which charges the solar thermal bank with enough thermal energy stored. After a while, the cooking process can be completed by users using that stored heat. The top cavity is used as a cooking pot in a solar thermal bank. Cooking meals do not require direct sunlight, which is typical for most solar cookers. The portable solar thermal bank is an alternative for low-income households and adapts to local traditions of indoor cooking. It is portable and can be used safely to cook indoors or outdoors. In this study, a solar cooker with a thermal storage device was developed using a PCM. The size of the stove has been calculated by calculating the energy consumption for two to three people. HITEC salt has been chosen as a phase change material for thermal storage, which will be used for cooking when there is no sunlight. It enhances the applicability of solar cooking and preserves cooking possibilities using energy stored throughout the day at low production costs. 相似文献
In the context of comparing two treatments in clinical trials randomized play-the-winner rule is used with the goal of treating more patients by the better treatment On its basis we give two decision rules by introducing stopping rule Some performance characteristics of one of the decision rules are discussed and examined .A minimax rule is suggested Finally some exact and asymptotic properties of the decision rule is derived 相似文献