Modeling techniques suitable for CAD-based design of internal matching networks of high-power RF/microwave transistors

A scalable and accurate simulation technique to be used for the computer-aided design (CAD) of matching networks employed within high-power RF transistors is presented. A novel measurement methodology is developed and utilized during the validation of the proposed analysis approach. Appropriate segmentation techniques were developed, which are consistent with the design approach of the high-power transistor, that take into account the overall complexity of the internal match of most modern RF high-power transistors, while preserving important electromagnetic interactions. By being able to properly decouple the linear portion of the overall packaged transistor model, an objective accuracy assessment via the comparison of measured versus simulated results of the internal matching network was accomplished. The level of accuracy obtained provides credence to the idea of a full CAD-driven design process of the internal match of high-power RF transistors.     

Aerobic degradation by white‐rot fungi of trichloroethylene (TCE) and mixtures of TCE and perchloroethylene (PCE)

BACKGROUND: Trichloroethylene (TCE) and perchloroethylene (PCE) are considered among the most important groundwater pollutants around the world. These compounds are usually found together in polluted environments but little is known about the ability of microorganisms to simultaneously degrade TCE and PCE. RESULTS: Data showed that several species of white‐rot fungi, including Trametes versicolor, Ganoderma lucidum, and Irpex lacteus, degrade substantial levels of TCE in pure culture. T. versicolor was chosen for further study since it degraded higher levels of TCE than the other organisms. Initial glucose concentration and reoxygenation of samples increased the amount of TCE dechlorination, but no significant difference in percentage TCE degradation was observed. T. versicolor was able to degrade 34.1 and 47.7% of PCE and TCE added as mixtures (containing 5 and 10 mg L⁻¹, respectively). CONCLUSIONS: The degradation ability of TCE was extended to other species of white‐rot fungi. Percentage degradation as well as chloride release from mixtures of TCE and PCE showed that T. versicolor degrades mixtures of TCE and PCE almost as well as its ability to degrade individually added TCE or PCE. The results suggest the potential promise of T. versicolor for bioremediation of TCE and PCE in the environment. Copyright © 2008 Society of Chemical Industry     

Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

We currently lack effective treatments for the devastating loss of neural function associated with spinal cord injury (SCI). In this study, we evaluated a combination therapy comprising human neural stem cells derived from induced pluripotent stem cells (iPSC-NSC), human mesenchymal stem cells (MSC), and a pH-responsive polyacetal–curcumin nanoconjugate (PA-C) that allows the sustained release of curcumin. In vitro analysis demonstrated that PA-C treatment protected iPSC-NSC from oxidative damage in vitro, while MSC co-culture prevented lipopolysaccharide-induced activation of nuclear factor-κB (NF-κB) in iPSC-NSC. Then, we evaluated the combination of PA-C delivery into the intrathecal space in a rat model of contusive SCI with stem cell transplantation. While we failed to observe significant improvements in locomotor function (BBB scale) in treated animals, histological analysis revealed that PA-C-treated or PA-C and iPSC-NSC + MSC-treated animals displayed significantly smaller scars, while PA-C and iPSC-NSC + MSC treatment induced the preservation of β-III Tubulin-positive axons. iPSC-NSC + MSC transplantation fostered the preservation of motoneurons and myelinated tracts, while PA-C treatment polarized microglia into an anti-inflammatory phenotype. Overall, the combination of stem cell transplantation and PA-C treatment confers higher neuroprotective effects compared to individual treatments.     

Study of rotational mobility of stable nitroxide radicals in solid polymers

The rotational mobility of stable nitroxide radicals in PS, PMMA, PVC, PP and PE has been studied over a wide temperature range by the e.s.r. method. At temperatures T lower than T_g, spin probes act as kinetically independent particles, the rotational frequency of which is deter mined mainly by the micropore dimensions of the polymer and depends indirectly on the mobility of segments or side groups.     

Modeling of a cokneader for the manufacturing of composite materials having absorbent properties at ultra‐high‐frequency waves. Part 1: Modeling of flow from residence time distribution investigations

The purpose of this study is to gain better understanding of flow patterns and mixing conditions in a particular single‐screw extruder: the Buss Cokneader. To this end, the residence time distribution (RTD) of the polymer was investigated experimentally for different combinations of the operating variables (i.e. feed rate, screw rotation speed). The measurement of RTD used a standard stimulus‐response technique. Two kinds of tracer were used: free anthracene and anthracene grafted on the polymer. It was shown that only the second could characterize the actual flow of the polymer in the extruder. It does not perturb the flow and has the same rheological behavior as the studied fluid. Thanks to the RTD data, a model of the extruder based on the combination of ideal reactors, such as continuous stirred tank reactors or plug flow reactors, was finally set up. The establishment of relationships between model parameters and extrusion conditions allowed the prediction of RTD with good agreement.     

Self-managed topologies in P2P networks

The problem of efficient resource location is an important open issue in P2P systems. This paper introduces DANTE, a self-adapting P2P system that changes its peer links to form topologies where resources are located in an efficient manner via random walks. Additionally, this same self-adaptation capacity makes DANTE capable of reacting to events like changes in the system load or attacks on well-connected nodes by adjusting the topology to the new scenario. This adaptive behavior emerges as the global result of the individual work of nodes, without the intervention of any central entity or the need for global knowledge. Simulations show that this adaptation process makes the system scalable, resilient to attacks, and tolerant to a high transitivity of peers. Simulations are also used to compare this solution with other well-known self-adapting P2P system. From these results it can be concluded that the topologies achieved by DANTE offer better performance.     

Skeleton computation of orthogonal polyhedra

Skeletons are powerful geometric abstractions that provide useful representations for a number of geometric operations. The straight skeleton has a lower combinatorial complexity compared with the medial axis. Moreover, while the medial axis of a polyhedron is composed of quadric surfaces the straight skeleton just consist of planar faces. Although there exist several methods to compute the straight skeleton of a polygon, the straight skeleton of polyhedra has been paid much less attention. We require to compute the skeleton of very large datasets storing orthogonal polyhedra. Furthermore, we need to treat geometric degeneracies that usually arise when dealing with orthogonal polyhedra. We present a new approach so as to robustly compute the straight skeleton of orthogonal polyhedra. We follow a geometric technique that works directly with the boundary of an orthogonal polyhedron. Our approach is output sensitive with respect to the number of vertices of the skeleton and solves geometric degeneracies. Unlike the existing straight skeleton algorithms that shrink the object boundary to obtain the skeleton, our algorithm relies on the plane sweep paradigm. The resulting skeleton is only composed of axis‐aligned and 45° rotated planar faces and edges.     

A technique for fractionated stereotactic radiotherapy in the treatment of intracranial tumors

PURPOSE: The excellent treatment results obtained with traditional radiosurgery have stimulated attempts to broaden the range of intracranial disorders treated with radiosurgical techniques. For major users of radiosurgery this resulted in a gradual shift from treating vascular diseases in a single session to treating small, well delineated primary tumors on a fractionated basis. In this paper we present the technique currently used in Montreal for the fractionated stereotactic radiotherapy of selected intracranial lesions. METHODS AND MATERIALS: The regimen of six fractions given every other day has been in use for "fractionated stereotactic radiotherapy" in our center for the past 5 years. Our current irradiation technique, however, evolved from our initial method of using the stereotactic frame for target localization and first treatment, and a "halo-ring" with tattoo skin marks for the subsequent treatments. Recently, we developed a more precise irradiation technique, based on an in-house-built stereotactic frame which is left attached to the patient's skull for the duration of the fractionated regimen. Patients are treated with the stereotactic dynamic rotation technique on a 10 MV linear accelerator (linac). RESULTS: In preparation for the first treatment, the stereotactic frame is attached to the patient's skull and the coordinates of the target center are determined. The dose distribution is then calculated, the target coordinates are marked onto a Lucite target localization box, and the patient is placed into the treatment position on the linac with the help of laser positioning devices. The Lucite target localization box is then removed, the target information is tattooed on the patient's skin, and the patient is given the first treatment. The tattoo marks in conjunction with the target information on the Lucite target localization box are used for patient set-up on the linac for the subsequent 5 treatments. The location of the target center is marked with radio-opaque markers on the target localization box and verified with a computerized tomography scanner prior to the second treatment. The same verification is done prior to other treatments when the target center indicated by the target localization box disagrees with that indicated by the tattoo marks. The new position of the target center is then determined and used for treatment positioning. CONCLUSION: The in-house-built frame is inexpensive and easily left attached to the patient's skull for the 12 day duration of the fractionated regimen. Positioning with the Lucite target localization box verified with tattoo marks ensures a high level of precision for individual fractionated treatments.