Group sequential crossover trial designs with strong control of the familywise error rate

Crossover designs are an extremely useful tool to investigators, and group sequential methods have proven highly proficient at improving the efficiency of parallel group trials. Yet, group sequential methods and crossover designs have rarely been paired together. One possible explanation for this could be the absence of a formal proof of how to strongly control the familywise error rate in the case when multiple comparisons will be made. Here, we provide this proof, valid for any number of initial experimental treatments and any number of stages, when results are analyzed using a linear mixed model. We then establish formulae for the expected sample size and expected number of observations of such a trial, given any choice of stopping boundaries. Finally, utilizing the four-treatment, four-period TOMADO trial as an example, we demonstrate that group sequential methods in this setting could have reduced the trials expected number of observations under the global null hypothesis by over 33%.     

A Genetically-Based Latitudinal Cline in the Emission of Herbivore-Induced Plant Volatile Organic Compounds

The existence of predictable latitudinal variation in plant defense against herbivores remains controversial. A prevailing view holds that higher levels of plant defense evolve at low latitudes compared to high latitudes as an adaptive plant response to higher herbivore pressure on low-latitude plants. To date, this prediction has not been examined with respect to volatile organic compounds (VOCs) that many plants emit, often thus attracting the natural enemies of herbivores. Here, we compared genetically-based constitutive and herbivore-induced aboveground vegetative VOC emissions from plants originating across a gradient of more than 10° of latitude (>1,500 km). We collected headspace VOCs from Asclepias syriaca (common milkweed) originating from 20 populations across its natural range and grown in a common garden near the range center. Feeding by specialist Danaus plexippus (monarch) larvae induced VOCs, and field environmental conditions (temperature, light, and humidity) also influenced emissions. Monarch damage increased plant VOC concentrations and altered VOC blends. We found that genetically-based induced VOC emissions varied with the latitude of plant population origin, although the pattern followed the reverse of that predicted—induced VOC concentration increased with increasing latitude. This pattern appeared to be driven by a greater induction of sesquiterpenoids at higher latitudes. In contrast, constitutive VOC emission did not vary systematically with latitude, and the induction of green leafy volatiles declined with latitude. Our results do not support the prevailing view that plant defense is greater at lower than at higher latitudes. That the pattern holds only for herbivore-induced VOC emission, and not constitutive emission, suggests that latitudinal variation in VOCs is not a simple adaptive response to climatic factors.     

Lightpath Rerouting Algorithm to enhance blocking performance in all-optical WDM network without wavelength conversion

In this paper, we have proposed an efficient wavelength rerouting algorithm for dynamic provisioning of lightpath. In wavelength-division multiplexed (WDM) networks rerouting of lightpath can be used to improve throughput and to reduce blocking probability. We have proposed a Lightpath Rerouting Algorithm (LRRA) for dynamic traffic in WDM optical networks. The results have shown that LRRA can improve blocking performance of the network. In this paper, low complexity algorithm has been developed which is used for the calculation of blocking probability of network. The proposed algorithm has also been applied on the realistic network such as NSFnet for calculation and optimization of blocking probability of the network. The results have also shown that the proposed algorithm can be implemented to huge networks for good blocking performance of the network.     

Rheology of Precipitated Silica in Epoxies

Epoxy resins are used in the RP/C industry when high-quality resins are needed. Adhesives, castings, and maintenance coatings are three areas where epoxies are used. Their superior chemical resistance allows them to be used as coatings, and their low shrinkage makes them ideal for use in castings [1]. There is a need for viscosity control in some of these epoxy applications.     

Validation of process technologies for enhancing the safety of low-moisture foods: A review

The outbreaks linked to foodborne illnesses in low-moisture foods are frequently reported due to the occurrence of pathogenic microorganisms such as Salmonella Spp. Bacillus cereus, Clostridium spp., Cronobacter sakazakii, Escherichia coli, and Staphylococcus aureus. The ability of the pathogens to withstand the dry conditions and to develop resistance to heat is regarded as the major concern for the food industry dealing with low-moisture foods. In this regard, the present review is aimed to discuss the importance and the use of novel thermal and nonthermal technologies such as radiofrequency, steam pasteurization, plasma, and gaseous technologies for decontamination of foodborne pathogens in low-moisture foods and their microbial inactivation mechanisms. The review also summarizes the various sources of contamination and the factors influencing the survival and thermal resistance of pathogenic microorganisms in low-moisture foods. The literature survey indicated that the nonthermal techniques such as CO₂, high-pressure processing, and so on, may not offer effective microbial inactivation in low-moisture foods due to their insufficient moisture content. On the other hand, gases can penetrate deep inside the commodities and pores due to their higher diffusion properties and are regarded to have an advantage over thermal and other nonthermal processes. Further research is required to evaluate newer intervention strategies and combination treatments to enhance the microbial inactivation in low-moisture foods without significantly altering their organoleptic and nutritional quality.     

Multiple time-scale decomposition in cheap control problems--Singular control

A linear quadratic regulator problem where a small parameter μ²multiplies the control cost is considered. Asmu rightarrow 0, it exhibits a dynamic behavior with multiple time-scales, whereas formu = 0, it is a singular control problem. At first a multiparameter singularly perturbed model of the given problem is constructed by transferring the singularity that exists in the performance index to the dynamic equations. Then the problem is decomposed into several subproblems of minimal order, each pertaining to only one time-scale. The method developed permits under a single framework the characterization of asymptotic behavior of optimal closed-loop poles, state and control trajectories, performance index, and optimal transfer function asmu rightarrow 0. Moreover, the asymptotic solution brings into focus 1) the nature of singular control and its connection to transmission zeros and 2) the presence of various types of impulses and other higher order distributions in both state and control. The approach unifies and extends significantly several ideas previously somewhat disjoint.     

Predictive-focus illumination for reducing photodamage in live-cell microscopy

Due to photobleaching and phototoxicity induced by high-intensity excitation light, the number of fluorescence images that can be obtained in live cells is always limited. This limitation becomes particularly prominent in multidimensional recordings when multiple Z-planes are captured at every time point. Here we present a simple technique, termed predictive-focus illumination (PFI), which helps to minimize cells' exposure to light by decreasing the number of Z-planes that need to be captured in live-cell 3D time-lapse recordings. PFI utilizes computer tracking to predict positions of objects of interest (OOIs) and restricts image acquisition to small dynamic Z-regions centred on each OOI. Importantly, PFI does not require hardware modifications and it can be easily implemented on standard wide-field and spinning-disc confocal microscopes.     

Rerouting technique with dynamic traffic in WDM optical networks

In this paper, we have proposed an efficient wavelength rerouting algorithm for dynamic provisioning of lightpath. In wavelength division multiplexed (WDM) networks rerouting of lightpath can be used to improve throughput and to reduce blocking probability. We have proposed a shortest path wavelength rerouting (SPWRR) algorithm for dynamic traffic in WDM optical networks. The results have shown that SPWRR algorithm can improve blocking performance of the network. In this paper, low complexity algorithm has been developed which is used for the calculation of blocking probability of network. The proposed algorithm has also been applied on the realistic network such as NSFnet for calculation and optimization of blocking probability of the network.     

Current-Mode Multiphase Sinusoidal Oscillator Using Current Differencing Transconductance Amplifiers

This paper describes a simple current-controlled current-mode multiphase sinusoidal oscillator based on current differencing transconductance amplifiers (CDTAs) as active components. The proposed oscillator circuit, which employs only one CDTA and one grounded capacitor for each phase, can generate arbitrary n current-output signals (n being even or odd) equally spaced in phase, all at high output impedance terminals. The oscillation condition and the oscillation frequency can be controlled electronically and independently through the bias current of the CDTA. The oscillator has low-component count, low-sensitivity performance, and is highly suitable for monolithic implementation. PSPICE simulation results are given to confirm the operation of the proposed oscillator.