RF microelectronics for W-CDMA mobile communication systems

Third generation (3G) mobile communication systems are now just starting to be introduced. With a maximum data rate of 2 Mbit/s they will make wireless access to broadband data services like the Internet or video applications feasible. Most of the different physical layer technologies summarised under the acronym 3G are based on wideband-CDMA (W-CDMA), in contrast to existing second generation systems, which mostly use TDMA and FDMA. This has severe consequences for the design of the transceiver front-ends. During standardisation these were assumed to have an adequate RF performance yet they still present a performance bottleneck for the system. Starting with a short introduction to UMTS (Universal Mobile Telecommunications System)-the 3G standard to be deployed in Europe and already operating in Japan-this paper describes by way of example some of the test cases specified for UMTS and their impact on the analogue front-end. It is shown that accurate simulation of all the analogue and digital signal processing is necessary in order to predict the RF performance needed of today's commercial RFICs. The paper then presents and reviews some actual design examples. Finally, possible technologies and techniques for application in future mobile terminals are discussed     

A fast spatial-domain method for the suppression ofexcitation-induced spurious modes in SCN TLM

An efficient method for the suppression of excitation-induced spurious modes in the symmetrical condensed node (SCN) transmission-line matrix (TLM) method is presented for the general case of dielectric, anisotropic, or lossy media in planar structures. A special mapping of the field-excitation onto the wave amplitudes of the TLM algorithm completely prevents the emanation of the spurious modes. The application of the mapping in the k-ω space can be done for waveguides with low computational effort. The method is generalized for planar structures with high spatial frequencies of the field at the discontinuities. We use precomputed field templates at the entrance of the three-dimensional (3-D) structures. The mapping is mainly done in the space domain based on the quasi-TEM propagation of the guided waves to keep the computational effort low. Instead of the four-dimensional (4-D) k-ω transformation, only independent one-dimensional (1-D) transformations to the wave coefficient of the conductors direction and ω are necessary. In the case of propagation with low dispersion, the expenditure can be further reduced to 1-D transformations with respect to ω. The efficiency of the present method is demonstrated by investigation of a coplanar waveguide and a triplate waveguide     

The microscopy cell (MicCell), a versatile modular flowthrough system for cell biology, biomaterial research, and nanotechnology

We describe a novel microfluidic perfusion system for high-resolution microscopes. Its modular design allows pre-coating of the coverslip surface with reagents, biomolecules, or cells. A poly(dimethylsiloxane) (PDMS) layer is cast in a special molding station, using masters made by photolithography and dry etching of silicon or by photoresist patterning on glass or silicon. This channel system can be reused while the coverslip is exchanged between experiments. As normal fluidic connectors are used, the link to external, computer-programmable syringe pumps is standardized and various fluidic channel networks can be used in the same setup. The system can house hydrogel microvalves and microelectrodes close to the imaging area to control the influx of reaction partners. We present a range of applications, including single-molecule analysis by fluorescence correlation spectroscopy (FCS), manipulation of single molecules for nanostructuring by hydrodynamic flow fields or the action of motor proteins, generation of concentration gradients, trapping and stretching of live cells using optical fibers precisely mounted in the PDMS layer, and the integration of microelectrodes for actuation and sensing.     

The dual coated pit pathway hypothesis: vertebrate cells have both ancient and modern coated pit pathways for receptor mediated endocytosis

The SimPlate Total Plate Count (TPC) test, developed by IDEXX Laboratories, Inc., detects and quantitates total bacterial concentration in food after 24 h of incubation. The performance of SimPlate TPC was compared with that of the plate count agar (PCA) method for enumerating total bacterial concentration of 255 food samples representing 15 different food matrixes. Total bacterial counts on SimPlate TPC were measured after 24 h of incubation and plotted against values obtained from PCA after 48 h. Simple regression analysis of the data showed strong correlation between the methods (r = 0.95); the sensitivity of SimPlate TPC for foodborne bacteria was 96% relative to PCA (slope = 0.96). It was concluded that SimPlate TPC is a suitable alternative for the detection and quantitation of foodborne bacteria. The method has been granted Performance Tested Certification by the AOAC Research Institute.     

Efficient analysis tool for coupled-SAW-resonator filters

The advantages of the coupled-mode (COM) formalism and the transmission-matrix approach are combined in order to create exact and computationally efficient analysis and synthesis tools for the design of coupled surface acoustic wave resonator filters. The models for the filter components, in particular gratings, interdigital transducers (IDTs) and multistrip couplers (MSCs), are based on the COM approach that delivers closed-form expressions. To determine the pertinent COM parameters, the COM differential equations are solved and the solution is compared with analytically derived expressions from the transmission-matrix approach and the Green's function method. The most important second-order effects, such as energy storage, propagation loss, and mechanical and electrical loading, are fully taken into account. As an example, a two-pole, acoustically coupled resonator filter at 914.5 MHz on AT quartz is investigated. Excellent agreement between theory and measurement is found.     

Ultralow Expansion Glass as Material for Advanced Micromechanical Systems

Ultralow expansion (ULE) glasses are of special interest for temperature stabilized systems for example in precision metrology. Nowadays, ULE materials are mainly used in macroscopic and less in micromechanical systems. Reasons for this are a lack of technologies for parallel fabricating high-quality released microstructures with a high accuracy. As a result, there is a high demand in transferring these materials into miniaturized application examples, realistic system modeling, and the investigation of microscopic material properties. Herein, a technological base for fabricating released micromechanical structures and systems with a structure height above 100 μm in ULE 7972 glass is established. Herein, the main fabrication parameters that are important for the system design and contribute thus to the introduction of titanium silicate as material for glass-based micromechanical systems are discussed. To study the mechanical properties in combination with respective simulation models, microcantilevers are used as basic mechanical elements to evaluate technological parameters and other impact factors. The implemented models allow to predict the micromechanical system properties with a deviation of only ±5% and can thus effectively support the micromechanical system design in an early stage of development.     

聚酯长丝和短纤维用纺丝油剂

今后,聚酯（PET）长丝和短纤维的市场份额将不断增长,因而PET长丝和短纤维生产中所需的纺丝油剂将成为令人关注的产品。通过介绍纺丝油剂在PET长丝和短纤维上的应用,对PET纺丝油剂市场容量做出分析,并就最近几个月、最近几年基础化学原料和一些产品创新方面提出了初步性的意见：     

Assessing genomic prediction accuracy for Holstein sires using bootstrap aggregation sampling and leave-one-out cross validation

Since the introduction of genome-enabled prediction for dairy cattle in 2009, genomic selection has markedly changed many aspects of the dairy genetics industry and enhanced the rate of response to selection for most economically important traits. Young dairy bulls are genotyped to obtain their genomic predicted transmitting ability (GPTA) and reliability (REL) values. These GPTA are a main factor in most purchasing, marketing, and culling decisions until bulls reach 5 yr of age and their milk-recorded offspring become available. At that time, daughter yield deviations (DYD) can be compared with the GPTA computed several years earlier. For most bulls, the DYD align well with the initial predictions. However, for some bulls, the difference between DYD and corresponding GPTA is quite large, and published REL are of limited value in identifying such bulls. A method of bootstrap aggregation sampling (bagging) using genomic BLUP (GBLUP) was applied to predict the GPTA of 2,963, 2,963, and 2,803 young Holstein bulls for protein yield, somatic cell score, and daughter pregnancy rate (DPR), respectively. For each trait, 50 bootstrap samples from a reference population comprising 2011 DYD of 8,610, 8,405, and 7,945 older Holstein bulls were used. Leave-one-out cross validation was also performed to assess prediction accuracy when removing specific bulls from the reference population. The main objectives of this study were (1) to assess the extent to which current REL values and alternative measures of variability, such as the bootstrap standard deviation (SD) of predictions, could detect bulls whose daughter performance deviates significantly from early genomic predictions, and (2) to identify factors associated with the reference population that inform about inaccurate genomic predictions. The SD of bootstrap predictions was a mildly useful metric for identifying bulls whose future daughter performance may deviate significantly from early GPTA for protein and DPR. Leave-one-out cross validation allowed us to identify groups of reference population bulls that were influential on other reference population bulls for protein yield and observe their effects on predictions of testing set bulls, as a whole and individually.     

Phosphorus content in soil, uptake by plants and balance in three European long-term field experiments

The fate of phosphorus (P) derived from mineral fertilisers and organic manures, and the effective P balance, have been assessed in three long-term field experiments at Rothamsted (UK), Bad Lauchstaedt (Germany) and Skierniewice (Poland). This paper discusses the plant availability, uptake and overall utilisation of P over the last 30 years, based on soil test P availability indices and crop analyses determined by the standard methods used in each of the three countries. The data suggest that differences in soil type significantly influence the dynamics of P at the three locations, but most significantly between a loess Chernozem at Bad Lauchstaedt with a high organic matter content and the soils at the other two locations which have a low organic matter content. The application of P either as inorganic fertiliser or organic manure had a considerable influence on the availablity, uptake, leaching or fixing of P, but the crop recovery rate of P from mineral fertiliser did not exceed 35% with the smallest recovery (average 18%) occurring in the soil with the highest clay content at Rothamsted. At Bad Lauchstaedt and Rothamsted the most efficient utilisation of P (averages of 47% and 37%, respectively) was from soils treated with farmyard manure (FYM), with the greater quantity of P either leached or fixed (8 and 25 kg ha^-1 y^-1, respectively) occurring in soils treated with superphosphate. At Skierniewice, however, the reverse was true. Overall, the most efficient crop utilisation from mineral P (30% average) was from the loamy sand at Skierniewice. P balances for the three locations show that quantitatively, for the same P input, the amount of P either leached from or fixed in the plough layer of Broadbalk field, Rothamsted, was 2–3 times greater than at Skierniewice and 3–6 times greater than at Bad Lauchstaedt. The results suggest that differences in the soil physico-chemical properties, climate, the availability of other major nutrients, and the form in which P is applied, all influence the effectiveness of P fertilisation and P balance. The investigation highlights the importance of maintaining long-term field experiments and archived soil and crop samples on a world-wide basis for understanding nutrient cycling and fertility dynamics.     

Genomic architecture of bovine κ-casein and β-lactoglobulin

The objective of this study was to characterize the genetic architecture underlying the absolute concentrations of 2 important milk proteins, κ-casein (κ-CN) and β-lactoglobulin (β-LG), in a backcross population of (Holstein × Jersey) × Holstein cattle. A genome-wide association analysis was performed using a selective DNA pooling strategy and the Illumina BovineHD BeadChip assay [777,000 (777K) SNP markers; Illumina Inc., San Diego, CA]. After correction for multiple testing, 25 single nucleotide polymorphisms were found to be associated with κ-CN and 36 single nucleotide polymorphisms were associated with β-LG. A pathway association analysis revealed 15 Gene Ontology (GO) terms associated with the κ-CN trait and 28 GO terms associated with β-LG. In addition, several GO terms were associated with both milk proteins. Further analysis revealed that κ-CN and β-LG production is regulated by both kinase and phosphatase activity, including mechanisms regulating the extracellular matrix. These results are in concordance with the complex multihormonal process controlling the expression of milk proteins and interactions between mammary epithelial cells and extracellular matrix components. Although κ-CN and β-LG milk proteins are expressed by single genes, the results from this study showed that many loci are involved in the regulation of the concentration of these 2 proteins.