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排序方式: 共有5068条查询结果,搜索用时 31 毫秒
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Dr. Blijke S. Kroezen Gabriele Conti Benedetta Girardi Dr. Jonathan Cramer Dr. Xiaohua Jiang Dr. Said Rabbani Jennifer Müller Maja Kokot Enrico Luisoni Prof. Daniel Ricklin Dr. Oliver Schwardt Prof. Beat Ernst 《ChemMedChem》2020,15(18):1706-1719
Siglecs are members of the immunoglobulin gene family containing sialic acid binding N-terminal domains. Among them, Siglec-8 is expressed on various cell types of the immune system such as eosinophils, mast cells and weakly on basophils. Cross-linking of Siglec-8 with monoclonal antibodies triggers apoptosis in eosinophils and inhibits degranulation of mast cells, making Siglec-8 a promising target for the treatment of eosinophil- and mast cell-associated diseases such as asthma. The tetrasaccharide 6’-sulfo-sialyl Lewisx has been identified as a specific Siglec-8 ligand in glycan array screening. Here, we describe an extended study enlightening the pharmacophores of 6’-sulfo-sialyl Lewisx and the successful development of a high-affinity mimetic. Retaining the neuraminic acid core, the introduction of a carbocyclic mimetic of the Gal moiety and a sulfonamide substituent in the 9-position gave a 20-fold improved binding affinity. Finally, the residence time, which usually is the Achilles tendon of carbohydrate/lectin interactions, could be improved. 相似文献
2.
何晓华 《安徽工业大学学报》2020,37(2):112-118
以江苏某企业的石英尾砂为研究对象,基于Jenike剪切理论,分析石英尾砂的物料性质、四棱锥料仓结构对重力流卸料的影响,考虑料仓卸料口尺寸和斜锥角对料仓内物料流动状态的影响,设计石英尾砂料仓及其辅助气力助流系统,且将其应用于江苏某企业试运行。结果表明:石英尾砂的含水率在14%(质量分数)时,物料的内摩擦角最大,物料粒径越细小,物料内摩擦角越大,但达150μm时增势趋于平缓;设计的石英尾砂料仓及其辅助气力助流系统可保障物料装卸料性能和防止物料堵仓;年产2万t石英尾砂的条件下,设计的石英尾砂料仓及其辅助气力助流系统可为企业节省200万元的生产成本,且社会环境效益显著。 相似文献
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An optimization model for placement of wavelength converters to minimize blocking probability in WDM networks 总被引:7,自引:0,他引:7
Suixiang Gao Xiaohua Jia Chuanhe Huang Ding-Zhu Du 《Lightwave Technology, Journal of》2003,21(3):684-694
The introduction of wavelength converters in wavelength division multiplexing (WDM) networks can reduce the blocking probabilities of calls. In this paper, we study the problem of placing a given number of converters in a general topology WDM network such that the overall system blocking probability is minimized. The original contributions of this work are the following: 1) formulation of success probability in a network as a polynomial function of the locations of converters; 2) proposal of an optimization model of the converter placement problem as the minimization of a polynomial function of 0-1 variables under a linear constraint, so that standard optimization tools can be employed to solve the problem; and 3) design of a search algorithm that can efficiently find the optimal solution to the converter placement problem. Experiments have been conducted to demonstrate the effectiveness of the proposed model and the efficiency of the algorithm. 相似文献
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ZHANG Liqing WU Xiaohua 《武汉理工大学学报(材料科学英文版)》2005,20(3):119-121
1IntroductionWuweizi is a traditional Chinese herb,usually usedto cure cough,asthma,neurasthenic,hepatitisetc.Theactive ingredients in wuweizi are5%-22%lignan,themain components of which include deoxyschizandrin,schizandrin andγ-Schizandrin.Forthe purpos… 相似文献
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Itwasreported[1] thatthemicro stereostructureofprimaryausteniteincastironconsistsofprimarystemsandsecondaryarmsthat growaccordingtodendritecrystalsbranchrule ,andsomeofprimaryausteniteevenhavethirdarms .MiyakeHetal[2 ]proposedaconceptofregionmodelbystudying… 相似文献
9.
Blind channel estimation and equalization in wireless sensor networks based on correlations among sensors 总被引:2,自引:0,他引:2
Xiaohua Li 《Signal Processing, IEEE Transactions on》2005,53(4):1511-1519
In densely deployed wireless sensor networks, signals of adjacent sensors can be highly cross-correlated. This paper proposes to utilize such a property to develop efficient and robust blind channel identification and equalization algorithms. Blind equalization can be performed with complexity as low as O(N/spl tilde/), where N/spl tilde/ is the length of equalizers. Transmissions can be more power and bandwidth efficient in multipath propagation environment, which is especially important for wideband sensor networks such as those for acoustic location or video surveillance. The cross-correlation property of sensor signals and the finite sample effect are analyzed quantitatively to guide the design of low duty-cycle sensor networks. Simulations demonstrate the superior performance of the proposed method. 相似文献
10.
Huayi Wu Xiaohua Jia Yanxiang He Chuanhe Huang 《International Journal of Communication Systems》2005,18(9):803-816
This paper investigates the issues of QoS routing in CDMA/TDMA ad hoc networks. Since the available bandwidth is very limited in ad hoc networks, a QoS request between two nodes will be blocked if there does not exist a path that can meet the QoS requirements, even though there is enough free bandwidth in the whole system. In this paper, we propose a new scheme of using multiple paths between two nodes as the route for a QoS call. The aggregate bandwidth of the multiple paths can meet the bandwidth requirement of the call and the delays of these paths are within the required bound of the call. We also propose three strategies by which to choose a set of paths as the route, namely, shortest path first (SPF), largest bandwidth first (LBF), and largest hop‐bandwidth first (LHBF). Extensive simulations have been conducted to evaluate the performance of the three strategies in comparison with a traditional single path routing algorithm. The simulation results show that the proposed multiple paths routing scheme significantly reduces the system blocking rates in various network environments, especially when the network load is heavy. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献