超声破坏微泡治疗大鼠下肢血管闭塞的研究

目的用超声破坏微泡的方法促进大鼠下肢血管闭塞模型的血管新生.方法30只大鼠随机分为3组,建立下肢血管闭塞模型,一组采用超声破坏微泡的方法;一组单纯超声作用;一组作为对照.14天后处死各组大鼠,用免疫组织化学方法观察骨骼肌组织中血管内皮生长因子(vascular endothelial growth factor VEGF)的表达和血管新生情况.结果用超声破坏微泡的方法可在大鼠血管闭塞模型中促进VEGF的表达和缺血骨骼肌的血管再生,与单纯超声组和对照组比较有显著性差异.结论超声破坏微泡可促进血管闭塞后骨骼肌中VEGF的表达和血管新生.     

Application of persulfate in low-temperature atmospheric-pressure plasma jet for enhanced treatment of onychomycosis

Fungal infection of human nails,or onychomycosis,affects 10%of the world's adult population,but current therapies have various drawbacks.In this work,we employed a self-made low-temperature plasma(LTP)device,namely,an atmospheric-pressure plasma jet(APPJ)device to treat the nails infected with Trichophyton rubrum(T.rubrum)with the aid of persulfate solution.We found that persulfate solution had a promoting effect on plasma treatment of onychomycosis.With addition of sodium persulfate,the APPJ therapy could cure onychomycosis after several times of treatment.As such,this work has demonstrated a novel and effective approach which makes good use of LTP technique in the treatment of onychomycosis.