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1.
Karim Gharbi Louise Matthews James Bron Ron Roberts Alan Tinch Michael Stear 《Journal of the Royal Society Interface》2015,12(110)
Sea lice threaten the welfare of farmed Atlantic salmon and the sustainability of fish farming across the world. Chemical treatments are the major method of control but drug resistance means that alternatives are urgently needed. Selective breeding can be a cheap and effective alternative. Here, we combine experimental trials and diagnostics to provide a practical protocol for quantifying resistance to sea lice. We then combined quantitative genetics with epidemiological modelling to make the first prediction of the response to selection, quantified in terms of reduced need for chemical treatments. We infected over 1400 young fish with Lepeophtheirus salmonis, the most important species in the Northern Hemisphere. Mechanisms of resistance were expressed early in infection. Consequently, the number of lice per fish and the ranking of families were very similar at 7 and 17 days post infection, providing a stable window for assessing susceptibility to infection. The heritability of lice numbers within this time window was moderately high at 0.3, confirming that selective breeding is viable. We combined an epidemiological model of sea lice infection and control on a salmon farm with genetic variation in susceptibility among individuals. We simulated 10 generations of selective breeding and examined the frequency of treatments needed to control infection. Our model predicted that substantially fewer chemical treatments are needed to control lice outbreaks in selected populations and chemical treatment could be unnecessary after 10 generations of selection. Selective breeding for sea lice resistance should reduce the impact of sea lice on fish health and thus substantially improve the sustainability of Atlantic salmon production. 相似文献
2.
Different forms of generativity in the writings of E. H. Erikson (1950/1963) and J. Kotre (1984) were related to agentic and communal motives in a sample of young adults (M?=?28 yrs old). For women, the power motive related to parenting, whereas the achievement motive was associated with forms of generative expression outside of the household. The opposite pattern of achievement and power motive relationships was found for men, although in a weaker form. The affiliation–intimacy motive, on the other hand, related both to women's parenting and societal concerns. Differences in expectations and opportunities for young men and women may account for these gender differences. The results for women support D. P. McAdams's (1988) suggestions that agency and communion are important for understanding generativity. In addition, the results provide evidence that people begin to grapple with generative issues as young adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Stewart Abigail J.; Antonucci Toni C.; Veroff Joanne B. 《Canadian Metallurgical Quarterly》2003,58(5):405
Presents an obituary for Elizabeth Douvan (1926-2002). Douvan was a pioneer in the study of changing gender, work, and family roles; personal values; and well-being in the second half of the 20th century. Through her research, she contributed to the interdisciplinary fields of social psychology and women's studies while building and strengthening institutions that remain committed to the same mission. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Tang Guannan Gould Benjamin J. Ngowe Abigail Rollett Anthony D. 《Metallurgical and Materials Transactions A》2022,53(8):3204-3204
Metallurgical and Materials Transactions A - 相似文献
5.
Tang Guannan Gould Benjamin J. Ngowe Abigail Rollett Anthony D. 《Metallurgical and Materials Transactions A》2022,53(4):1486-1498
Metallurgical and Materials Transactions A - Hot cracking is one of the major defects that can occur in laser-based additive manufacturing. During the terminal stage of solidification, hot cracking... 相似文献
6.
Kenton O’Hara Gerardo Gonzalez Graeme Penney Abigail Sellen Robert Corish Helena Mentis Andreas Varnavas Antonio Criminisi Mark Rouncefield Neville Dastur Tom Carrell 《Computer Supported Cooperative Work (CSCW)》2014,23(3):299-337
While surgical practices are increasingly reliant on a range of digital imaging technologies, the ability for clinicians to interact and manipulate these digital representations in the operating theatre using traditional touch based interaction devices is constrained by the need to maintain sterility. To overcome these concerns with sterility, a number of researchers are have been developing ways of enabling interaction in the operating theatre using touchless interaction techniques such as gesture and voice to allow clinicians control of the systems. While there have been important technical strides in the area, there has been little in the way of understanding the use of these touchless systems in practice. With this in mind we present a touchless system developed for use during vascular surgery. We deployed the system in the endovascular suite of a large hospital for use in the context of real procedures. We present findings from a study of the system in use focusing on how, with touchless interaction, the visual resources were embedded and made meaningful in the collaborative practices of surgery. In particular we discuss the importance of direct and dynamic control of the images by the clinicians in the context of talk and in the context of other artefact use as well as the work performed by members of the clinical team to make themselves sensable by the system. We discuss the broader implications of these findings for how we think about the design, evaluation and use of these systems. 相似文献
7.
Connie Golsteijn Elise van den Hoven David Frohlich Abigail Sellen 《Personal and Ubiquitous Computing》2014,18(3):593-611
With current digital technologies, people have large archives of digital media, such as images and audio files, but there are only limited means to include these media in creative practices of crafting and making. Nevertheless, studies have shown that crafting with digital media often makes these media more cherished and that people enjoy being creative with their digital media. This paper aims to open up the way for novel means for crafting, which include digital media in integrations with physical construction, here called ‘hybrid crafting’. Notions of hybrid crafting were explored to inform the design of products or systems that may support these new crafting practices. We designed ‘Materialise’—a building set that allows for the inclusion of digital images and audio files in physical constructions by using tangible building blocks that can display images or play audio files, alongside a variety of other physical components—and used this set in four hands-on creative workshops to gain insight into how people go about doing hybrid crafting; whether hybrid crafting is desirable; what the characteristics of hybrid crafting are; and how we may design to support these practices. By reflecting on the findings from these workshops, we provide concrete guidelines for the design of novel hybrid crafting products or systems that address craft context, process and result. We aim to open up the design space to designing for hybrid crafting because these new practices provide interesting new challenges and opportunities for future crafting that can lead to novel forms of creative expression. 相似文献
8.
Harry McCarthy Abigail Koay Michael Dawson Kenneth B. Kent Panos Patros 《Software》2022,52(1):172-193
Tablets, smartphones, and wearables have limited resources. Applications on these devices employ a graphical user interface (GUI) for interaction with users. Language runtimes for GUIs employ dynamic memory management using garbage collection (GC). However, GC policies and algorithms are designed for data centers and cloud computing, but they are not necessarily ideal for resource-constrained embedded devices. In this article, we present GUI GC, a JavaFX GUI benchmark, which we use to compare the performance of the four GC policies of the Eclipse OpenJ9 Java runtime on a resource-constrained environment. Overall, our experiments suggest that the default policy Gencon registered significantly lower execution times than its counterparts. The region-based policy, Balanced, did not fully utilize blocking times; thus, using GUI GC, we conducted experiments with explicit GC invocations that measured significant improvements of up to 13.22% when multiple CPUs were available. Furthermore, we created a second version of GUI GC that expands on the number of controllable load-stressing dimensions; we conducted a large number of randomly configured experiments to quantify the performance effect that each knob has. Finally, we analyzed our dataset to derive suitable knob configurations for desired runtime, GC, and hardware stress levels. 相似文献
9.
10.
Programmable logic designs are presented that achieve exact integration of leaky integrate-and-fire soma and dynamical synapse neuronal models and incorporate spike-time dependent plasticity and axonal delays. Highly accurate numerical performance has been achieved by modifying simpler forward-Euler-based circuitry requiring minimal circuit allocation, which, as we show, behaves equivalently to exact integration. These designs have been implemented and simulated at the behavioral and physical device levels, demonstrating close agreement with both numerical and analytical results. By exploiting finely grained parallelism and single clock cycle numerical iteration, these designs achieve simulation speeds at least five orders of magnitude faster than the nervous system, termed here hyper-real-time operation, when deployed on commercially available field-programmable gate array (FPGA) devices. Taken together, our designs form a programmable logic construction kit of commonly used neuronal model elements that supports the building of large and complex architectures of spiking neuron networks for real-time neuromorphic implementation, neurophysiological interfacing, or efficient parameter space investigations. 相似文献