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排序方式: 共有474条查询结果,搜索用时 31 毫秒
1.
Iratxe Perez-Arnedo María J. Cantalejo Alba Martínez-Laorden Elena Gonzalez-Fandos 《International Journal of Food Science & Technology》2021,56(4):1855-1864
Microbiological contamination of chicken meat depends on the conditions under which the animals are reared, slaughtered and processed. The aim of this study was to determine the influence of farm origin and processing stages at slaughterhouse on the microbial safety and quality of chicken. Samples of chicken carcasses from three different farms were taken from a slaughterhouse. Mesophiles, Escherichia coli, coagulase positive Staphylococcci counts, presence of Listeria monocytogenes,Campylobacter and Salmonella were determined at five sampling points: after defeathering, after evisceration, after washing, after chilling and after cutting. Chilling reduced log numbers of mesophiles, coagulase positive Staphylococci and E. coli by 0.85, 1.52 and 2.2 log units, respectively. Salmonella was not detected after chilling. High prevalence of Campylobacter spp was observed at all the stages ranging between 84% and 100%. L. monocytogenes was not detected in chicken carcasses after defeathering. However, it was detected after evisceration and after washing and chilling. The most critical stage for L. monocytogenes contamination was the portioning operation, the prevalence in breast and legs being 88% and 84%, respectively. 相似文献
2.
Myriam Gonzlez María Ovejero-Snchez Alba Vicente-Blzquez Raquel lvarez Ana B. Herrero Manuel Medarde Rogelio Gonzlez-Sarmiento Rafael Pelez 《International journal of molecular sciences》2021,22(4)
Pan-Gyn cancers entail 1 in 5 cancer cases worldwide, breast cancer being the most commonly diagnosed and responsible for most cancer deaths in women. The high incidence and mortality of these malignancies, together with the handicaps of taxanes—first-line treatments—turn the development of alternative therapeutics into an urgency. Taxanes exhibit low water solubility that require formulations that involve side effects. These drugs are often associated with dose-limiting toxicities and with the appearance of multi-drug resistance (MDR). Here, we propose targeting tubulin with compounds directed to the colchicine site, as their smaller size offer pharmacokinetic advantages and make them less prone to MDR efflux. We have prepared 52 new Microtubule Destabilizing Sulfonamides (MDS) that mostly avoid MDR-mediated resistance and with improved aqueous solubility. The most potent compounds, N-methyl-N-(3,4,5-trimethoxyphenyl-4-methylaminobenzenesulfonamide 38, N-methyl-N-(3,4,5-trimethoxyphenyl-4-methoxy-3-aminobenzenesulfonamide 42, and N-benzyl-N-(3,4,5-trimethoxyphenyl-4-methoxy-3-aminobenzenesulfonamide 45 show nanomolar antiproliferative potencies against ovarian, breast, and cervix carcinoma cells, similar or even better than paclitaxel. Compounds behave as tubulin-binding agents, causing an evident disruption of the microtubule network, in vitro Tubulin Polymerization Inhibition (TPI), and mitotic catastrophe followed by apoptosis. Our results suggest that these novel MDS may be promising alternatives to taxane-based chemotherapy in chemoresistant Pan-Gyn cancers. 相似文献
3.
Vendrame L. Zabotto E. Dal Fabbro A. Zanini A. Verzellesi G. Zanoni E. Chantre A. Pavan P. 《Electron Devices, IEEE Transactions on》1995,42(9):1636-1646
In this paper we describe a set of measurements representing a complete characterization of impact-ionization effects in bipolar transistors. We demonstrate that impact-ionization significantly influences the dependence of base resistance on current and voltages applied to the device. A dc method for the simultaneous extraction of all parasitic resistances in bipolar transistors is presented. The method can separate the influence of current-crowding on the base resistance from that of base width and conductivity modulation; the collector parasitic resistance is measured in the active region. Starting from the parameters extracted by means of these techniques, a complete and accurate circuit-model of impact-ionization effects can be defined 相似文献
4.
M Loscertales Abril F Jaldo Alba E Díaz Lucas E Narbona López A Ruiz Extremera E Ocete Hita JA Molina Font 《Canadian Metallurgical Quarterly》1993,39(4):339-342
Four patients who complained of symptoms and signs compatible with biliary tract disease and in whom the diagnosis of gallbladder (three cases) and common bile duct ascariasis (one case) was made sonographically are reported. In two patients with gallbladder ascariasis, cholecystectomy corroborated the presence of the round-worms, and was curative. The third patient was a pregnant woman (32nd gestational week) who took piperazine citrate, and a second sonogram performed 29 days later was completely normal. The fourth patient with common bile duct ascariasis underwent choledochotomy with extraction of one ascaris lumbricoides from the common duct, and a T tube was left in place for 15 days. All patients received antiparasitics and had a favorable outcome. Ultrasonography is an important noninvasive diagnostic procedure in the work-up of these patients, who usually describe a clinical picture suggesting gallstone disease: this is especially true in the presence of pregnancy. 相似文献
5.
A. Cigada B. Mazza P. Pedeferri G. Salvago D. Sinigaglia G. Zanini 《Corrosion Science》1982,22(6):559-578
Stress corrosion cracking (SCC) of AISI 304L and AISI 316L stainless steels, cold-worked under various conditions (i.e. at different degrees of deformation obtained by drawing and rolling at room temperature and at liquid nitrogen temperature) has been carried out in H2O containing 1000 ppm Cl? at 250°C and in a boiling MgCl2 solution. The effect of heat treatments at 400 and 900°C on the SCC of previously cold-worked steels has also been studied. Particular attention was directed towards heat treatment at 400°C. In steels deformed at room temperature, it increases the SCC resistance. By contrast, for steels deformed at liquid nitrogen temperature, heat treatment at 400°C reduces the SCC resistance if carried out for short periods of time (1–6 h). Hardness measurements, structural analyses via X-rays, scanning and transmission electron microscopy (SEM and TEM), as well as modified Strauss tests, seem to prove that reduced stress corrosion resistance is not to be related to the chromium-rich carbides precipitation which could have been accelerated by the presence of α′-martensite. Instead, they tend to suggest that perhaps this phenomenon is connected to an increase in the level of internal micro-stresses which are generated by a reciprocal re-ordering of the α′ and γ structural phases. 相似文献
6.
M.?MelgosaEmail author R.?Huertas E.?Hita J.?M.?Roa F.?J.?Heredia J.?Alba M.?J.?Moyano 《Journal of the American Oil Chemists' Society》2004,81(4):323-330
A new color scale was developed from a broad data set of 1700 virgin olive oil samples over four crop seasons, which can be
considered highly representative of the whole color range of virgin olive oils available in Spain. This color scale provides
a new set of 60 color standards, improving the results achieved by the old 60-color standards proposed by the bromthymol blue
method. Seeking the greatest possibility of including a near match between colors of virgin olive oils and proposed standards,
we developed our new color scale using a recent uniform color space, with standards placed in a regular rhombohedral lattice
like the one employed by the Uniform Color Scales of the Optical Society of America. The average color difference between
each of the 1700 virgin olive oils and its nearest standard is reduced from 8.17 CIELAB units, using the bromthymol blue standards,
to 3.99 CIELAB units using the new standards. Within a color tolerance of 7.0 CIELAB units, 93.2% of our virgin olive oils
can be classified with the new standards, but only 59.1% with the bromthymol blue ones. In the interest of future adoption,
the performance of the new color standards should be tested by industry and researchers. 相似文献
7.
Larissa S. Martins Noelle C. Zanini Alexandre L. S. Botelho Daniella R. Mulinari 《Polymer Engineering and Science》2021,61(7):2055-2065
Oil spill accidents in marine environments and the lack of disposal of post-consumer plastic are environmental problems worldwide. This study presents a sustainable alternative for both issues through envelopes filled with microplastics (MPs) from recycled bags for the sorption of spilled crude oil. Through particle size analysis by three different sieves (4, 9, and 20 mesh), different MP sizes were characterized by scanning electron microscope (SEM), Brunauer–Emmett–Teller (BET), density, contact angle (CA), and Fourier-transform infrared spectroscopy (FTIR). According to their sizes, the MPs were distributed in envelopes and submitted to crude oil sorption capacity and efficiency evaluation. Three MP particle sizes were obtained (from the largest to the smallest, according to the sieve mesh, MP4, MP9, and MP20). SEM images of samples exhibited irregular and porous surfaces, and MP4 had the smallest pore size (8.6 μm). BET showed that MP4 had the highest surface area (0.074 m2/g). The CA > 90° exposed that all samples were hydrophobic. FTIR spectrum demonstrated that the samples from the recycled bags were made of high density polyethylene (HDPE). The MP4 envelopes also had the best crude oil sorption results in capacity and efficiency (1.73 g/g and 68%, respectively), being a promising recycled sorbent in crude oil spillage applications. 相似文献
8.
Javier Arellano-Verdejo Enrique Alba Salvador Godoy-Calderon 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2016,20(3):895-905
Clustering algorithms, a fundamental base for data mining procedures and learning techniques, suffer from the lack of efficient methods for determining the optimal number of clusters to be found in an arbitrary dataset. The few methods existing in the literature always use some sort of evolutionary algorithm having a cluster validation index as its objective function. In this article, a new evolutionary algorithm, based on a hybrid model of global and local heuristic search, is proposed for the same task, and some experimentation is done with different datasets and indexes. Due to its design, independent of any clustering procedure, it is applicable to virtually any clustering method like the widely used \(k\)-means algorithm. Moreover, the use of non-parametric statistical tests over the experimental results, clearly show the proposed algorithm to be more efficient than other evolutionary algorithms currently used for the same task. 相似文献
9.
10.
Gravel constitutes the filter medium in subsurface flow constructed wetlands (SSF CWs) and its porosity and hydraulic conductivity decrease over time (clogging), limiting the lifespan of the systems. Using gravel of poor quality accelerates clogging in wetlands. In this study, gravel samples from six different wetland systems were compared with regards to their mineral composition and mechanical resistance properties. Results showed that both mineralogy and texture are related to mechanical resistance. Accordingly, gravel with high content of quartz (> 80%) showed a lower percentage of broken particles (0.18-1.03%) than those with lower content of quartz (2.42-4.56% media broken). Although granite is formed by high durability minerals, its non-uniform texture results in a lower resistance to abrasion (ca. 10% less resistance than calcareous gravel). Therefore, it is recommended to use gravels composed mainly of quartz or, when it is not available, limestone gravels (rounded and uniform) are recommended instead. The resistance to abrasion (LAA test) seems to be a good indicator to determine the mechanical properties of gravels used in CWs. It is recommended to use gravels with LAA below 30% in order to avoid a rapid clogging due to gravel crumbling and subsequent mineral solids accumulation. 相似文献