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排序方式: 共有121条查询结果,搜索用时 15 毫秒
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Magnetic Resonance Materials in Physics, Biology and Medicine - In this paper, we review the developments of 1H-MR spectroscopic imaging (MRSI) methods designed to investigate prostate cancer,... 相似文献
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The semantic definition of action refinement on labelled configuration structures is compared with the notion ofsyntactic substitution, which can be used as another notion of action refinement in a process algebraic setting. The comparison is done by studying a process algebra equipped with sequential composition, parallel composition with an explicit synchronisation set, and an operator for action refinement. On the one hand, the language (including the refinement operator) is given a configuration structure semantics. On the other hand, a reduction procedure transforms a process termPinto aflatterm (i.e., with the refinement operator not occurring in it)red(P) by means of syntactic substitution, defined in a structural inductive way. The main aim of the paper is to investigate general conditions under which the termsPandred(P) have the same semantics. The results we present are essentially dependent on the question whether the refined action can be synchronised or not. In the latter case,Pandred(P) give rise to isomorphic configuration structures under mild assumptions. The former case is considerably more difficult, since then refinement cannot be expected to distribute over parallel composition. We give necessary and sufficientsemanticconditions under which distribution still holds up to semantic equivalence. Subsequently, we also give sufficient (but not necessary)syntacticconditions for reducible terms. Finally, we generalise these results to a language with recursion. 相似文献
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Enhancement of phenolic compounds content and antioxidant activity of strawberry (Fragaria × ananassa) juice by block freeze concentration technology
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Wantiê T. Adorno Katia Rezzadori Giordana D. Arend Vitor C. Chaves Flávio H. Reginatto Marco Di Luccio José C.C. Petrus 《International Journal of Food Science & Technology》2017,52(3):781-787
The aim of this study was to evaluate the effects of freeze concentration of strawberry juice on content of total phenolic, anthocyanins content and antioxidant activity of the concentrated fluid and the ice obtained. An increase in the values of phenolic content was observed in the concentrate fraction for all the freeze concentration stages (five stages). The process efficiency presented a reduction when compared with the first stage, and however, the average efficiency remained around 65% in all the stages. The concentration of pelargonidin‐3‐O‐glycoside present in samples was increased in all stages. Furthermore, the antioxidant activity of the concentrated fluid of each stage, measured by DPPH and ABTS methods, was significantly higher in comparison with the juice feed. Also, antioxidant activity can be correlated with the content of pelargonidin‐3‐O‐glycoside presented in the strawberry juice. Freeze concentration can be considered a good alternative for improving the antioxidant activity of strawberry juice. 相似文献
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Janssen Marcel J.W.; van de Wiel Wendy A.E.C.; Beiboer Sigrid H.W.; van Kampen Muriel D.; Verheij Hubertus M.; Slotboom Arend J.; Egmond Maarten R. 《Protein engineering, design & selection : PEDS》1999,12(6):497-503
The catalytic contribution of His48 in the active site of porcinepancreatic phospholipase A2 was examined using site-directedmutagenesis. Replacement of His48 by lysine (H48K) gives riseto a protein having a distorted lipid binding pocket. Activityof this variant drops below the detection limit which is 107-foldlower than that of the wild-type enzyme. On the other hand,the presence of glutamine (H48Q) or asparagine (H48N) at thisposition does not affect the structural integrity of the enzymeas can be derived from the preserved lipid binding propertiesof these variants. However, the substitutions H48Q and H48Nstrongly reduce the turnover number, i.e. by a factor of 105.Residual activity is totally lost after addition of a competitiveinhibitor. We conclude that proper lipid binding on its ownaccelerates ester bond hydrolysis by a factor of 102. With theselected variants, we were also able to dissect the contributionof the hydrogen bond between Asp99 and His48 on conformationalstability, being 5.2 kJ/mol. Another hydrogen bond with His48is formed when the competitive inhibitor (R)-2-dodecanoylamino-hexanol-1-phosphoglycolinteracts with the enzyme. Its contribution to binding of theinhibitor in the presence of an interface was found to be 5.7kJ/mol. 相似文献
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Johannes Jacobi Renke Maas Michaela Arend Nada Cordasic Karl F. Hilgers 《International journal of molecular sciences》2014,15(4):5522-5535
The purpose of the work was to study the impact of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and its degrading enzyme, dimethylarginine dimethylaminohydrolase (DDAH1), on atherosclerosis in subtotally nephrectomized (SNX) ApoE-deficient mice. Male DDAH1 transgenic mice (TG, n = 39) and C57Bl/6J wild-type littermates (WT, n = 27) with or without the deletion of the ApoE gene underwent SNX at the age of eight weeks. Animals were sacrificed at 12 months of age, and blood chemistry, as well as the extent of atherosclerosis within the entire aorta were analyzed. Sham treated (no renal mass reduction) ApoE-competent DDAH1 transgenic and wild-type littermates (n = 11) served as a control group. Overexpression of DDAH1 was associated with significantly lower ADMA levels in all treatment groups. Surprisingly, SNX mice did not exhibit higher ADMA levels compared to sham treated control mice. Furthermore, the degree of atherosclerosis in ApoE-deficient mice with SNX was similar in mice with or without overexpression of DDAH1. Overexpression of the ADMA degrading enzyme, DDAH1, did not ameliorate atherosclerosis in ApoE-deficient SNX mice. Furthermore, SNX in mice had no impact on ADMA levels, suggesting a minor role of this molecule in chronic kidney disease (CKD) in this mouse model. 相似文献
8.
Magnetic Resonance Materials in Physics, Biology and Medicine - Molecular interactions in prostatic fluid are of biological interest and may affect MRI and MRS of the prostate. We investigated the... 相似文献
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This paper addresses the problem of sectoral approach in the formulation and assessment of projects in development co-operation. Sectoral studies and reports often ignore cross-links between aspects covering poverty, gender, culture, social and institutional fabric, and environment. A first important improvement would be to synchronise the execution of the various sectoral studies. Further improvement may be found in the integration of sectoral studies. Two different forms can be distinguished. At a lower level of integration, the studies are required to focus on a common set of alternatives. At a higher level, one single assessment will cover all relevant cross-sectoral aspects. The paper presents some preliminary reflections and experiences by the Commission for Environmental Impact Assessment in the Netherlands on development of a conceptual framework for integration of assessments. 相似文献
10.
A Discrete Fourier-Cosine Transform Chip 总被引:1,自引:0,他引:1
An 8-point Fourier-cosine transform chip designed for a data rate of 100 Mbits/s is described. The top-down design is presented step by step, including algorithm modification for VLSI suitability, architectural choices, testing overhead, internal precision assignments, mask generation, and finally, verification of the layout. A high-level language (C) design tool was developed concurrently with the layout. This tool allows mimicking exactly the different representations of the algorithm: software, mask, and chip. This provides an automatic cross-checking at all design stages. The VLSI environment created by this tool, as well as existing powerful CAD tools, made a fast design-time possible. 相似文献