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排序方式: 共有172条查询结果,搜索用时 23 毫秒
1.
Comparison of finite element reliability methods 总被引:7,自引:0,他引:7
The spectral stochastic finite element method (SSFEM) aims at constructing a probabilistic representation of the response of a mechanical system, whose material properties are random fields. The response quantities, e.g. the nodal displacements, are represented by a polynomial series expansion in terms of standard normal random variables. This expansion is usually post-processed to obtain the second-order statistical moments of the response quantities. However, in the literature, the SSFEM has also been suggested as a method for reliability analysis. No careful examination of this potential has been made yet. In this paper, the SSFEM is considered in conjunction with the first-order reliability method (FORM) and with importance sampling for finite element reliability analysis. This approach is compared with the direct coupling of a FORM reliability code and a finite element code. The two procedures are applied to the reliability analysis of the settlement of a foundation lying on a randomly heterogeneous soil layer. The results are used to make a comprehensive comparison of the two methods in terms of their relative accuracies and efficiencies. 相似文献
2.
Yurii S. Borovikov Daria D. Andreeva Stanislava V. Avrova Vladimir V. Sirenko Armen O. Simonyan Charles S. Redwood Olga E. Karpicheva 《International journal of molecular sciences》2021,22(12)
Point mutations in the genes encoding the skeletal muscle isoforms of tropomyosin can cause a range of muscle diseases. The amino acid substitution of Arg for Pro residue in the 90th position (R90P) in γ-tropomyosin (Tpm3.12) is associated with congenital fiber type disproportion and muscle weakness. The molecular mechanisms underlying muscle dysfunction in this disease remain unclear. Here, we observed that this mutation causes an abnormally high Ca2+-sensitivity of myofilaments in vitro and in muscle fibers. To determine the critical conformational changes that myosin, actin, and tropomyosin undergo during the ATPase cycle and the alterations in these changes caused by R90P replacement in Tpm3.12, we used polarized fluorimetry. It was shown that the R90P mutation inhibits the ability of tropomyosin to shift towards the outer domains of actin, which is accompanied by the almost complete depression of troponin’s ability to switch actin monomers off and to reduce the amount of the myosin heads weakly bound to F-actin at a low Ca2+. These changes in the behavior of tropomyosin and the troponin–tropomyosin complex, as well as in the balance of strongly and weakly bound myosin heads in the ATPase cycle may underlie the occurrence of both abnormally high Ca2+-sensitivity and muscle weakness. BDM, an inhibitor of myosin ATPase activity, and W7, a troponin C antagonist, restore the ability of tropomyosin for Ca2+-dependent movement and the ability of the troponin–tropomyosin complex to switch actin monomers off, demonstrating a weakening of the damaging effect of the R90P mutation on muscle contractility. 相似文献
3.
Melikyan H Hovsepyan A Sargsyan T Yoon Y Yoo H Babajanyan A Lee K 《Ultramicroscopy》2008,108(10):1030-1033
We investigated the electromagnetic properties of metals of iron, nickel, cobalt, aluminum, gold, copper, silver, and permalloy thin films on SiO(2) substrates using a near-field microwave microprobe. The electromagnetic properties of metal sheets were estimated by measuring the microwave reflection coefficient S(11) and compared with the theoretical values. We observed the hysteresis behavior of permalloy thin films on SiO(2) substrates using a near-field scanning microwave microprobes (NSMM) system. Experimental results are in good agreement with the theoretical model of transmission theory. In order to better characterize the electromagnetic properties of metals and magnetic metals instead of the usual method, we take advantage of the noncontact microprobing evaluation capabilities using a near-field microwave. 相似文献
4.
Abbas Rastgoo Armen Amirian 《International Journal of Mechanics and Materials in Design》2006,3(3):253-264
This study presents three mathematical methods namely the polynomial stress function approach, the Fourier series form approach
and the approximated equations form approach for finding the stress distribution in a cantilever beam with rectangular cross
section loaded by a parabolically distributed load. By taking the stress function as a polynomial of the seventh degree, it
is attempted to find the coefficients either in complete or in full shape of the polynomial. In the Fourier series approach,
the load is discreted to unlimited series of harmonic loads and superposing resultant stresses is the affect of parabolically
distributed load on the beam. The resultant stresses are compared with some approximated stress formulas which have been provided
before. Finite element analysis are done for square, short, medium and long cantilever beams and the mathematical results
of stress distribution in five different height of the beam was compared with FEM results. It was found good results for τ
yy
and τ
xy
in all cross section of the beams and acceptable results for τ
xx
only in y = 0. It is found that discreting loads to even a limit number of harmonic loads and superposing the resultant stresses can
give the distribution of τ
yy
and τ
xy
with the acceptable precision in medium and long cantilever beams with rectangular cross section. 相似文献
5.
6.
Karen Trchounian Satenik Mirzoyan Anna Poladyan Armen Trchounian 《International Journal of Hydrogen Energy》2017,42(38):24026-24034
The Escherichia coli BW25113 or MC4100 wild type parental strains growth and H2 production kinetics was studied in batch cultures of minimal salt medium (MSM) and peptone medium (PM) at pH of 5.5–7.5 upon glycerol (10 g L?1) fermentation and formate (0.68 g L?1) supplementation. The role of formate alone or with glycerol on growth and H2 production via hydrogenases (Hyd) was investigated in double hyaB hybC (lacking large subunits of Hyd 1 and 2), triple hyaB hybC hycE (lacking large subunits of Hyds 1-3) and sole selC (lacking formate dehydrogenase H) mutants during 24 h bacterial growth. H2 production was delayed and observed after 24 h bacterial wild type strains growth on MSM. Moreover, it reached the maximal values after 72 h growth at the pH 6.5 and pH 7.5. Biomass formation of the mutants used was inhibited ~3.5 fold compared with wild type, and H2 production was absent in hyaB hybC hycE and selC mutants upon glycerol utilization on MSM at pHs of 5.5–7.5. Formate inhibited bacterial growth on MSM with glycerol, but enhanced and recovered H2 production by hybC mutant at pH 7.5. H2 evolution was delayed at pH 7.5 in PM, but observed and stimulated at pH 6.5 upon glycerol and formate utilization in hyaB hybC mutant. H2 production was absent in hyaB hybC hycE and selC mutants upon glycerol, formate alone or with glycerol fermentation at pH 6.5 and pH 7.5; formate supplementation had no effect. The results point out E. coli ability to grow and utilize glycerol in MSM with comparably high H2 yield: as well as they suggest the key role of Hyd-3 at both pH 6.5 and pH 7.5 and the role of Hyd-2 and Hyd-4 at pH 7.5 in H2 production by E. coli during glycerol fermentation with formate supplementation. The results obtained are novel and might be useful in H2 production biotechnology development using different nutrient media and glycerol and formate as feedstock. 相似文献
7.
The first-passage probability, describing the probability that a scalar process exceeds a prescribed threshold during an interval of time, is of great engineering interest. This probability is essential for estimating the reliability of a structural component whose response is a stochastic process. When considering the reliability of an engineering system composed of several interdependent components, the probability that two or more response processes exceed their respective safe thresholds during the operation time of the system is an equally essential quantity. This paper proposes simple and accurate formulas for approximating this joint first-passage probability of a vector process. The nth order joint first-passage probability is obtained from a recursive formula involving lower order joint first-passage probabilities and the out-crossing probability of the vector process over a safe domain. Interdependence between the crossings is approximately accounted for by considering the clumping of these events. The accuracy of the proposed formulas is examined by comparing analytical estimates with those obtained from Monte Carlo simulations for stationary Gaussian processes. As an example application, the reliability of a system of interconnected equipment items subjected to a stochastic earthquake excitation is estimated by linear programming bounds employing marginal and joint component fragilities obtained by the proposed formulas. 相似文献
8.
Elasto-plastic wave propagation in a one dimensional rod is treated by utilizing finite element analysis. The time dependence is handled by means of a variable time step numerical integration method. Elasto-plastic reflections from a fixed boundary and interaction of plastic waves are discussed.
Theoretical expressions are presented for determining the stress response for a material exhibiting bilinear hardening behavior during elasto-plastic wave interaction and boundary reflection. These expressions are employed to evaluate predictions made by the numerical procedure.
In the computations, steep wave fronts are approximated by ramps. The steepness of these ramps may be increased by refining the finite element grid. Excellent agreement is obtained between numerical and theoretical elastic and inelastic stress response levels. 相似文献
9.
Surface and phased array receiving coils in MRI typically require that RF excitation be accomplished using the body coil.
This process requires that the receiving coils contain blocking circuitry to increase the overall circuit impedance during
RF excitation and withstand the electromotive force induced by the applied electromagnetic field. The aim of this study was
to determine the optimal impedance range required during RF excitation based on an assessment of image quality. The experimental
results are fit by an exponential model and establish criteria that can be applied for general receiver coil design. 相似文献
10.
Liana Sargsyan Austin R. Swisher Alisa P. Hetrick Hongzhe Li 《International journal of molecular sciences》2022,23(13)
Combining aminoglycosides and loop diuretics often serves as an effective ototoxic approach to deafen experimental animals. The treatment results in rapid hair cell loss with extended macrophage presence in the cochlea, creating a sterile inflammatory environment. Although the early recruitment of macrophages is typically neuroprotective, the delay in the resolution of macrophage activity can be a complication if the damaged cochlea is used as a model to study subsequent therapeutic strategies. Here, we applied a high dose combination of systemic gentamicin and furosemide in C57 BL/6 and CBA/CaJ mice and studied the ototoxic consequences in the cochlea, including hair cell survival, ribbon synaptic integrity, and macrophage activation up to 15-day posttreatment. The activity of macrophages in the basilar membrane was correlated to the severity of cochlear damage, particularly the hair cell damage. Comparatively, C57 BL/6 cochleae were more vulnerable to the ototoxic challenge with escalated macrophage activation. In addition, the ribbon synaptic deterioration was disproportionately limited when compared to the degree of outer hair cell loss in CBA/CaJ mice. The innate and differential otoprotection in CBA/CaJ mice appears to be associated with the rapid activation of cochlear macrophages and a certain level of synaptogenesis after the combined gentamicin and furosemide treatment. 相似文献