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排序方式: 共有195条查询结果,搜索用时 15 毫秒
1.
Ugur Gezer Ebru E. Y?rüker Metin Keskin Cemil Burak Kulle Yoganiranjana Dharuman Stefan Holdenrieder 《International journal of molecular sciences》2015,16(12):29654-29662
Circulating nucleic acids (CNAs) are under investigation as a liquid biopsy in cancer as potential non-invasive biomarkers, as stable structure in circulation nucleosomes could be valuable sources for detection of cancer-specific alterations in histone modifications. Our interest is in histone methylation marks with a focus on colorectal cancer, one of the leading cancers respective the incidence and mortality. Our previous work included the analysis of trimethylations of lysine 9 on histone 3 (H3K9me3) and of lysine 20 on histone 4 (H4K20me3) by chromatin immuno- precipitation-related PCR in circulating nucleosomes. Here we asked whether global immunologic measurement of histone marks in circulation could be a suitable approach to show their potential as biomarkers. In addition to H3K9me3 and H4K20me3 we also measured H3K27me3 in plasma samples from CRC patients (n = 63) and cancer free individuals (n = 40) by ELISA-based methylation assays. Our results show that of three marks, the amounts of H3K27me3 (p = 0.04) and H4K20me3 (p < 0.001) were significantly lower in CRC patients than in healthy controls. For H3K9me3 similar amounts were measured in both groups. Areas under the curve (AUC) in receiver operating characteristic (ROC) curves indicating the power of CRC detection were 0.620 for H3K27me3, 0.715 for H4K20me3 and 0.769 for the combination of both markers. In conclusion, findings of this preliminary study reveal the potential of blood-based detection of CRC by quantification of histone methylation marks and the additive effect of the marker combination. 相似文献
2.
Atar Musa Keskin Hakan Güçlü Yavuzcan H. 《Journal of Coatings Technology and Research》2004,1(3):219-224
The impacts of impregnation and bleaching on the varnish layer hardness of Oriental beech (Fagus orientalist L.) wood were investigated. A number of bleaching combinations {[NaOH−H2O2], [NaOH−Ca(OH)2−H2O2], [NaOH−MgSO4−H2O2] [NaHSO3−H2C2O4], [NaSiO3−H2O2], [KMnO4+NaHSO3+H2O3]} were applied at 18% concentration for bleaching to both impregnated and unimpregnated specimens of Oriental beech wood.
Subsequently, water-based (WB) varnish was coated over the samples and the varnish layer hardness values were determined in
accordance with ASTM D 4366-95.
All of the chemicals used for bleaching reduced the surface hardness. However, after varnish coating, the hardness of most
samples was similar to that of the varnish-coated natural (control) samples. 相似文献
3.
Hiba Messaoudi Fayçal Djazi Mohamed Litim Bahadır Keskin Maamar Slimane Djillali Bekhiti 《Journal of Adhesion Science and Technology》2020,34(20):2216-2244
AbstractCorrosion inhibitors based on environmentally friendly and harmless products are currently being studied and developed. The corrosion inhibition properties of caffeine (1,3,7-trimethylxanthine) on copper corrosion in aqueous chloride solution (3.5?wt.% NaCl) are analysed here using stationary and transient electrochemical methods, and a theoretical study based on density functional theory is carried out. Caffeine is a very competitive compared to the chemical inhibitors that are often used for copper protection. Electrochemical and impedance experiments reveal that the protective efficiency of caffeine reaches a value of 96% at a concentration of 10?2?mol L?1. Based on these results, the Langmuir model appears to be the best representation of the adsorption of caffeine onto the copper surface. Scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and X-ray diffraction (XRD) were used to determine the surface morphology and the chemical composition of the copper surface in chloride media, in the absence and presence of caffeine. The results show the development of a mechanism of corrosion inhibition. In order to confirm the correlation between the inhibitory effect and the molecular structure of caffeine, quantum chemical parameters are used to calculate its electronic properties. 相似文献
4.
Martti Heinonen Miltiadis Anagnostou Stephanie Bell Mark Stevens Robert Benyon Reidun Anita Bergerud Jovan Bojkovski Rien Bosma Jan Nielsen Norbert B?se Plunkett Cromwell Aliye Kartal Dogan Seda Aytekin Ali Uytun Vito Fernicola Krzysztof Flakiewicz Bertrand Blanquart Domen Hudoklin Per Jacobson Anders Kentved Isabel Lóio George Mamontov Alexandra Masarykova Helmut Mitter Regina Mnguni Jan Otych Anton Steiner Nagyné Szilágyi Zsófia Davor Zvizdic 《International Journal of Thermophysics》2012,33(8-9):1422-1437
In the field of humidity quantities, the first CIPM key comparison, CCT-K6 is at its end. The corresponding European regional key comparison, EUROMET.T-K6, was completed in early 2008, about 4?years after the starting initial measurements in the project. In total, 24 NMIs from different countries took part in the comparison. This number includes 22 EURAMET countries, and Russia and South Africa. The comparison covered the dew-point temperature range from ?50?°C to +20?°C. It was carried out in three parallel loops, each with two chilled mirror hygrometers as transfer standards in each loop. The comparison scheme was designed to ensure high quality results with evenly spread workload for the participants. It is shown that the standard uncertainty due to the long-term instability was smaller than 0.008?°C in all loops. The standard uncertainties due to links between the loops were found to be smaller than 0.025?°C at ?50?°C and 0.010?°C elsewhere. Conclusions on the equivalence of the dew-point temperature standards are drawn on the basis of calculated bilateral degrees of equivalence and deviations from the EURAMET comparison reference values (ERV). Taking into account 16 different primary dew-point realizations and 8 secondary realizations, the results demonstrate the equivalence of a large number of laboratories at an uncertainty level that is better than achieved in other multilateral comparisons so far in the humidity field. 相似文献
5.
6.
Simay Yıldız Eren Aytekin Burçin Yavuz Nurşen Ünlü 《Drug development and industrial pharmacy》2016,42(6):1008-1017
AbstractObjective: Orally disintegrating tablets (ODTs) recently have gained much attention to fulfill the needs for pediatric, geriatric, and psychiatric patients with dysphagia. Aim of this study was to develop new ODT formulations containing mirtazapine, an antidepressant drug molecule having bitter taste, by using simple and inexpensive preparation methods such as coacervation, direct compression and to compare their characteristics with those of reference product (Remereon SolTab).Materials and methods: Coacervation method was chosen for taste masking of mirtazapine. In vitro characterization studies such as diameter and thickness, weight variation, tablet hardness, tablet friability and disintegration time were performed on tablet formulations. Wetting time and in vitro dissolution tests of developed ODTs also studied using 900?mL 0.1?N HCl medium, 900?mL pH 6.8 phosphate buffer or 900?mL pH 4.5 acetate buffer at 37?±?0.2?°C as dissolution medium.Results: Ratio of Eudragit® E-100 was chosen as 6% (w/w) since the dissolution profile of A1 (6% Eudragit® E-100) was found closer to the reference product than A2 (4% Eudragit® E-100) and A3 (8% Eudragit® E-100). Group D, E and F formulations were presented better results in terms of disintegration time. Dissolution results indicated that Group E and F formulations showed optimum properties in all three dissolution media.Discussion: Formulations D1, D4, D5, E3, E4, F1 and F5 found suitable as ODT formulations due to their favorable disintegration times and dissolution profiles.Conclusion: Developed mirtazapine ODTs were found promising in terms of showing the similar characteristics to the original formulation. 相似文献
7.
8.
Hydroxyapatite was doped with Y3+ (2.5, 5 and 7.5 mol%) and F− (2.5 mol%) ions (2.5YFHA, 5YFHA, 7.5YFHA, respectively) to compare its structural and mechanical properties and cellular response with pure-hydroxyapatite. No second phases were observed by X-ray diffraction spectra of 2.5YFHA. Doped hydroxyapatites had F− bonds in addition to OH− bonds. Hydroxyapatites sintered at 900 and 1100 °C were in nano-size. 7.5YFHA sintered at 1300 °C had the highest microhardness value. 2.5YFHA sintered at 1100 °C had the highest fracture toughness value. MTT viability assays showed high cell attachments on 2.5YFHA. Cell proliferation on 2.5YFHA and 5YFHA sintered at 1100 and 1300 °C was comparable with the control after 5-day culture. The highest ALP production and calcium deposition were observed on all hydroxyapatites sintered at 1100 °C. 2.5YFHA sintered at 1100 °C can be an alternative for hydroxyapatite in orthopedic applications. 相似文献
9.
In this study, experimental neutron-emission spectra produced by (n, xn) reactions on nuclei 232Th have been compared with experimental 238U(n, xn) neutron-emission spectra from 2 to 18 MeV. Angle-integrated cross-sections in neutron induced reactions on targets 238U have been calculated at the bombarding energies from 2 to 18 MeV. In the calculations, the geometry dependent hybrid model and the cascade exciton model including the effects of pre-equilibrium have been used. In addition, we have described how multiple pre-equilibrium emissions can be included in the Feshbach–Kerman-Koonin (FKK) fully quantum-mechanical theory. By analyzing (n, xn) reaction on 238U with the incident energy from 2 to 18 MeV, the importance of multiple pre-equilibrium emission can be seen clearly. All calculated results have been compared with experimental data. The obtained results have been discussed and compared with the available experimental data and found agreement with each other. 相似文献
10.
This study compared tensile bond strengths between conventional compression-molded heat (HC)-, auto (AP)-, and microwave-polymerized (MC) poly(methyl methacrylate)-based denture resins and a relatively new injection-molded, microwave-polymerized polyurethane based resin (MI) bonded to a highly cross-linked denture tooth. In the first part of the experiments, denture teeth were used as received. In the second part, they were treated with dichloromethane to see its effect on bonding of conventional denture bases (HCS and APS). Bond strength was tested in tension according to ADA specification No.15. The results showed that the HC group failed cohesively because of higher interface bonding (49.95 MPa) compared with those of the others (AP: 25.41 MPa; MC: 22.06 MPa; MI: 20.02 MPa). The application of dichloromethane improved bond strengths of HCS and APS groups (60.61 and 32.03 MPa, respectively). It was suggested that dichloromethane could be applied on the denture teeth ridge lap area prior to denture base processing to enhance adhesion between the tooth/resin. 相似文献