全文获取类型
收费全文 | 5531篇 |
免费 | 57篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 30篇 |
化学工业 | 447篇 |
金属工艺 | 35篇 |
机械仪表 | 77篇 |
建筑科学 | 124篇 |
矿业工程 | 5篇 |
能源动力 | 66篇 |
轻工业 | 208篇 |
水利工程 | 19篇 |
石油天然气 | 11篇 |
无线电 | 239篇 |
一般工业技术 | 415篇 |
冶金工业 | 3580篇 |
原子能技术 | 46篇 |
自动化技术 | 289篇 |
出版年
2021年 | 23篇 |
2020年 | 19篇 |
2019年 | 22篇 |
2018年 | 31篇 |
2017年 | 24篇 |
2016年 | 28篇 |
2015年 | 37篇 |
2014年 | 34篇 |
2013年 | 120篇 |
2012年 | 66篇 |
2011年 | 82篇 |
2010年 | 73篇 |
2009年 | 68篇 |
2008年 | 95篇 |
2007年 | 97篇 |
2006年 | 70篇 |
2005年 | 70篇 |
2004年 | 68篇 |
2003年 | 65篇 |
2002年 | 60篇 |
2001年 | 60篇 |
2000年 | 64篇 |
1999年 | 152篇 |
1998年 | 1039篇 |
1997年 | 630篇 |
1996年 | 414篇 |
1995年 | 234篇 |
1994年 | 197篇 |
1993年 | 235篇 |
1992年 | 76篇 |
1991年 | 77篇 |
1990年 | 59篇 |
1989年 | 75篇 |
1988年 | 89篇 |
1987年 | 63篇 |
1986年 | 61篇 |
1985年 | 68篇 |
1984年 | 44篇 |
1983年 | 37篇 |
1982年 | 44篇 |
1981年 | 68篇 |
1980年 | 46篇 |
1979年 | 33篇 |
1978年 | 34篇 |
1977年 | 103篇 |
1976年 | 218篇 |
1975年 | 40篇 |
1974年 | 19篇 |
1973年 | 31篇 |
1972年 | 20篇 |
排序方式: 共有5591条查询结果,搜索用时 31 毫秒
1.
2.
3.
KJ Shon M Grilley R Jacobsen GE Cartier C Hopkins WR Gray M Watkins DR Hillyard J Rivier J Torres D Yoshikami BM Olivera 《Canadian Metallurgical Quarterly》1997,36(31):9581-9587
A paralytic peptide, psi-conotoxin Piiie has been purified and characterized from Conus purpurascens venom. Electrophysiological studies indicate that the peptide inhibits the nicotinic acetylcholine receptor (nAChR). However, the peptide does not block the binding of alpha-bungarotoxin, a competitive nAChR antagonist. Thus, psi-conotoxin Piiie appears to inhibit the receptor at a site other than the acetylcholine-binding site. As ascertained by sequence analysis, mass spectrometry, and chemical synthesis, the peptide has the following covalent structure: HOOCCLYGKCRRYOGCSSASCCQR* (O = 4-trans hydroxyproline; * indicates an amidated C-terminus). The disulfide connectivity of the toxin is unrelated to the alpha- or the alphaA-conotoxins, the Conus peptide families that are competitive inhibitors of the nAChR, but shows homology to the mu-conotoxins (which are Na+ channel blockers). 相似文献
4.
JM Rumsey BC Donohue DR Brady K Nace JN Giedd P Andreason 《Canadian Metallurgical Quarterly》1997,54(12):1481-1489
The influence of ionic strength and composition on the binding and inhibition of human leukocyte elastase by glycosaminoglycans with variable degree and position of sulfation was investigated. The kinetic mechanism of inhibition had a hyperbolic, mixed-type character with a competitive component that was promoted by low ionic strength, reduced by phosphate ions, and which also depended on the substrate and glycosaminoglycan structure. Enzyme binding was a cooperative phenomenon that varied with ionic strength and composition. The inhibition patterns correlated with the cationic character of elastase and with the distribution of arginines on its molecular surface, most notably with residues located in the vicinity of the substrate binding region. The order of affinity for elastase binding was chondroitin 4-sulfate < chondroitin 6-sulfate < dermatan sulfate, iduronate-containing derivatives being superior with respect to the glucuronate-containing counterparts. Additional sulfation at both the 4- and 6- positions or at the N- and 4-positions of the N-acetylgalactosamine moiety decidedly improved the inhibitory efficiency. The results highlight a fundamental physiological role of enzyme-glycosaminoglycan interactions. In the azurophil granule of the human polymorphonuclear neutrophil, elastase and other enzymes are bound to a matrix of chondroitin 4-sulfate because this is the only glycosaminoglycan that simultaneously offers good binding for enzyme compartmentalization together with prompt release from the bound state at the onset of phagocytosis. 相似文献
5.
Sensory activity mediates regulation of tyrosine hydroxylase (TH), the first enzyme in the dopamine biosynthetic pathway, in the rodent olfactory bulb. The current studies established for the first time primary cultures of neonatal mouse olfactory bulb expressing TH and tested whether L-type calcium channels mediate the activity-dependent regulation of the dopamine phenotype. After 1 d in vitro (DIV), a small population of TH-immunostained neurons that lacked extensive processes could be demonstrated. After an additional 2 DIV in serum-free medium, the number of TH neurons had doubled, and they exhibited long interdigitating processes. Membrane depolarization for 48 hr with 50 mM KCl produced a further 2.4-fold increase in the number of TH-immunoreactive neurons compared with control cultures. Increased TH neuron number required at least 36 hr of exposure to KCl. Forskolin, which increases intracellular cAMP levels, induced a 1.5- to 1.6-fold increase in the number of TH-immunostained neurons. Combined treatment with KCl and forskolin was not additive. Nifedipine, an L-type calcium channel blocker, completely prevented the depolarization-mediated increase in TH expression but did not block the response to forskolin. Treatment with Bay K8644, an L-type calcium channel agonist, also significantly increased the number of TH-expressing neurons. Depolarization also induced alterations in neuritic outgrowth, resulting in a stellate versus an elongate morphology that, in contrast, was not prevented by nifedipine. These results are the first demonstration that in vitro, as in vivo, depolarization increases TH expression in olfactory bulb and that L-type calcium channels mediate this activity-dependent regulation of the dopamine phenotype. 相似文献
6.
7.
D Averill D Blockus B Brabson J Brom C Jung H Ogren DR Rust M Derrick P Kooijman JS Loos B Musgrave LE Price J Repond K Sugano B Cork C Akerlof J Chapman D Errede MT Ken DI Meyer H Neal D Nitz R Thun R Tschirhart S Abachi P Baringer BG Bylsma R DeBonte D Koltick EH Low RL McIlwain DH Miller CR Ng EI Shibata 《Canadian Metallurgical Quarterly》1989,39(1):123-137
8.
Structural engineers use design codes formulated to consider uncertainty for both reinforced concrete and structural steel
design. For a simple one-bay structural steel frame, we survey typical uncertainties and compute an interval solution for
displacements and forces. The naive solutions have large over-estimations, so we explore the Mullen-Muhanna assembly strategy,
scaling, and constraint propagation to achieve tight enclosures of the true ranges for displacements and forces in a fraction
of the CPU time typically used for simulations. That we compute tight enclosures, even for large parameter uncertainties used
in practice, suggests the promise of interval methods for much larger structures. 相似文献
9.
Norris Fran H.; Murphy Arthur D.; Baker Charlene K.; Perilla Julia L.; Rodriguez Francisco Gutiérrez; Rodriguez José de Jesús Gutiérrez 《Canadian Metallurgical Quarterly》2003,112(4):646
Prevalence rates of trauma and posttraumatic stress disorder (PTSD) were estimated from a probability sample of 2,509 adults from 4 cities in Mexico. PTSD was assessed according to Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 1994) criteria using the Composite International Diagnostic Interview (CIDI; WHO, 1997). Lifetime prevalence of exposure and PTSD were 76% and 11.2%, respectively. Risk for PTSD was highest in Oaxaca (the poorest city), persons of lower socioeconomic status, and women. Conditional risk for PTSD was highest following sexual violence, but nonsexual violence and traumatic bereavement had greater overall impact because of their frequency. Of lifetime cases, 62% became chronic; only 42% received medical or professional care. The research demonstrates the importance of expanding the epidemiologic research base on trauma to include developing countries around the world. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
M. A. Amer D. B. Kupranycz B. E. Baker 《Journal of the American Oil Chemists' Society》1985,62(11):1551-1557
Both summer and winter butterfats were fractionated using a laboratory procedure which was designed to simulate a commercial
fractionation process. The process is based on a slow, controlled cooling of the melted fat, a short stabilization time at
the fractionation temperature, and separation of the crystals from the liquid oil by vacuum filtration using a stainless steel
perforated disc. Fractionation temperatures of 29, 26, 23 and 19 C for winter butterfat and 29 and 19 C for summer butterfat
were used to obtain solid and liquid fractions at each temperature. Three replications at each temperature showed good reproducibility
of results. The fractions were characterized by their fatty acid and triglyceride compositions, melting and crystallization
behavior, iodine value, peroxide value and melting point.
Presented at the AOCS meeting in Philadelphia in May 1985. 相似文献