全文获取类型
收费全文 | 3012篇 |
免费 | 21篇 |
国内免费 | 7篇 |
专业分类
电工技术 | 22篇 |
化学工业 | 140篇 |
金属工艺 | 8篇 |
机械仪表 | 22篇 |
建筑科学 | 39篇 |
矿业工程 | 2篇 |
能源动力 | 11篇 |
轻工业 | 55篇 |
水利工程 | 13篇 |
石油天然气 | 5篇 |
无线电 | 109篇 |
一般工业技术 | 141篇 |
冶金工业 | 2395篇 |
原子能技术 | 3篇 |
自动化技术 | 75篇 |
出版年
2022年 | 5篇 |
2021年 | 5篇 |
2020年 | 7篇 |
2019年 | 4篇 |
2018年 | 11篇 |
2017年 | 5篇 |
2016年 | 11篇 |
2015年 | 9篇 |
2014年 | 8篇 |
2013年 | 43篇 |
2012年 | 14篇 |
2011年 | 29篇 |
2010年 | 26篇 |
2009年 | 16篇 |
2008年 | 32篇 |
2007年 | 36篇 |
2006年 | 31篇 |
2005年 | 20篇 |
2004年 | 18篇 |
2003年 | 21篇 |
2002年 | 24篇 |
2001年 | 14篇 |
2000年 | 12篇 |
1999年 | 82篇 |
1998年 | 688篇 |
1997年 | 423篇 |
1996年 | 256篇 |
1995年 | 149篇 |
1994年 | 144篇 |
1993年 | 156篇 |
1992年 | 27篇 |
1991年 | 34篇 |
1990年 | 30篇 |
1989年 | 39篇 |
1988年 | 43篇 |
1987年 | 46篇 |
1986年 | 41篇 |
1985年 | 35篇 |
1984年 | 10篇 |
1983年 | 9篇 |
1982年 | 19篇 |
1981年 | 19篇 |
1980年 | 38篇 |
1979年 | 5篇 |
1978年 | 12篇 |
1977年 | 93篇 |
1976年 | 202篇 |
1975年 | 9篇 |
1973年 | 4篇 |
1955年 | 5篇 |
排序方式: 共有3040条查询结果,搜索用时 31 毫秒
1.
Dr. Laurent David Dr. Mark Wenlock Dr. Patrick Barton Dr. Andreas Ritzén 《ChemMedChem》2021,16(17):2669-2685
Chameleonic properties, i. e., the capacity of a molecule to hide polarity in non-polar environments and expose it in water, help achieving sufficient permeability and solubility for drug molecules with high MW. We present models of experimental measures of polarity for a set of 24 FDA approved drugs (MW 405-1113) and one PROTAC (MW 1034). Conformational ensembles in aqueous and non-polar environments were generated using molecular dynamics. A linear regression model that predicts chromatographic apparent polarity (EPSA) with a mean unsigned error of 10 Å2 was derived based on separate terms for donor, acceptor, and total molecular SASA. A good correlation (R2=0.92) with an experimental measure of hydrogen bond donor potential, Δlog Poct-tol, was found for the mean hydrogen bond donor SASA of the conformational ensemble scaled with Abraham's A hydrogen bond acidity. Two quantitative measures of chameleonic behaviour, the chameleonic efficiency indices, are introduced. We envision that the methods presented herein will be useful to triage designed molecules and prioritize those with the best chance of achieving acceptable permeability and solubility. 相似文献
2.
3.
Renal cell carcinoma may metastasize to the head and neck region at different stages of its evolution. We present a case of an undiagnosed renal cell carcinoma presenting as an ear polyp, and discuss the difficulties of the diagnosis and the management of these tumours. 相似文献
4.
The purpose of this study was to determine whether retention of fetal lung liquid is more prevalent in polyalveolar congenital lobar emphysema than in conventional congenital lobar emphysema. Two patients with congenital lobar emphysema were prospectively identified in a 3-year period. Twenty-five such patients were identified in a retrospective study covering 39 years. Medical records were available for 22 patients who had 23 emphysematous lobes. Both babies from the prospective study and six subjects from the retrospective group had respiratory symptoms and underwent chest X-ray in the first day of life. Six of the eight babies with respiratory symptoms and chest imaging in the first day of life had retention of fetal lung liquid in an emphysematous lobe. All six of these lobes were polyalveolar. The lobe in one child was a polyalveolar lobe but without retained fetal lung liquid, and one child exhibited conventional lobar emphysema also without retained fetal lung liquid. One polyalveolar lobe caused no neonatal symptoms and was not imaged until the child was 3 months old. No baby with conventional lobar emphysema was shown to have retained fetal lung liquid. There seems to be a correlation between polyalveolar lobe and onset of respiratory symptoms in the first day of life. Retention of fetal lung liquid within the affected lobe was documented only in cases of polyalveolar lobe. 相似文献
5.
6.
7.
Douglas A SchwerJohn E Tolsma William H Green JrPaul I Barton 《Combustion and Flame》2002,128(3):270-291
A method of updating and reusing legacy FORTRAN codes for combustion simulations is presented using the DAEPACK software package. The procedure is demonstrated on two codes that come with the CHEMKIN-II package, CONP and SENKIN, for the constant-pressure batch reactor simulation. Using DAEPACK generated code, analytical derivative calculations, sparsity pattern information, and hidden discontinuity information can be obtained for the models of interest. This information can be easily integrated with different solvers giving the modeler great flexibility in selecting the best solution procedure. Using the generated code, the CONP code was connected to three different solvers, and the SENKIN code was connected to two different solvers. The effect of model formulation, analytical derivatives, sparsity, and sensitivity equation solution method were analyzed for three large kinetic mechanisms for methane, acetylene, and n-heptane. For the n-heptane model, with 544 species and 2446 reactions, a factor of 10-speed improvement over the original solution procedure was found using analytical derivatives and sparse linear algebra. For sensitivity calculations, for a small number of parameters, a factor of 55 improvement over the original solution procedure was found for the n-heptane problem. Upon closer examination of results, no one method is found to always be superior to other methods, and selection of the appropriate solution procedure requires an examination of the specific kinetic mechanism, which is easily conducted using DAEPACK generated code. 相似文献
8.
A theory is presented that explains how the visual system infers the lightness, opacity, and depth of surfaces from stereoscopic images. It is shown that the polarity and magnitude of image contrast play distinct roles in surface perception, which can be captured by 2 principles of perceptual inference. First, a contrast depth asymmetry principle articulates how the visual system computes the ordinal depth and lightness relationships from the polarity of local, binocularly matched image contrast. Second, a global transmittance anchoring principle expresses how variations in contrast magnitudes are used to infer the presence of transparent surfaces. It is argued that these principles provide a unified explanation of how the visual system computes the 3-D surface structure of opaque and transparent surfaces. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
10.
Non-functional variants of yeast mitochondrial ATP synthase subunit 8 that assemble into the complex
Myocardial and pulmonary beta-adrenoceptors can be imaged with 2-(S)-(-)-(9H-carbazol-4-yl-oxy)-3-[1-(fluoromethyl)ethyl]amino-2- propanol (S-1'-[18F]fluorocarazolol, I). Quantification of unmodified fluorocarazolol in plasma is necessary for analysis of PET images in terms of receptor densities. We have determined I and its radioactive metabolites in rat, sheep and human plasma, using (1) solid-phase extraction (C18) followed by reversed-phase HPLC and (2) direct injection of untreated plasma samples on an internal-surface reversed-phase (ISRP) column. The two methods were in good agreement. Unmodified I decreased from over 99% initially to less than 5%, 5-10% and 20% at 60 min post-injection in rats, sheep and human volunteers, respectively. Protein binding in sheep and human plasma was determined by ultrafiltration. The fraction of total plasma radioactivity bound to protein and the fraction representing unmodified radioligand were linearly correlated, suggesting that fluorocarazolol was more than 70% protein-bound, whereas its metabolites showed negligible protein binding. Direct injection of plasma on an ISRP column seems a convenient method for quantification of lipophilic radioligands such as fluorocarazolol. 相似文献