Food Process Engineering: The Last 25 Years and Challenges Ahead

In the first part of this contribution, an overview is given of some of the main developments in food process engineering in the last 25 years of the 20th century. This overview is, of course, colored by the personal experience of the authors, but a sincere effort was made to maintain a general perspective. Topics that will be briefly discussed are: progress in understanding how to control food microstructure formation during processing, separation processes, conversion processes and stabilization processes, progress in flavor technology and understanding of flavor retention during processing and release. In the 2nd part, in our view, the most exiting future developments are briefly discussed. The major items here are: processing requirements for functional foods, integrated process design approaches, application of novel‘fields’in food processes,‘precision’processing, supply chain approaches to food manufacturing, and more.     

Synthesis, estrogen receptor binding, and tissue distribution of a new iodovinylestradiol derivative (17alpha,20E)-21-[123I]Iodo-11beta-nitrato-19-norp regna-1,3,5 (10),20-tetraene-3,17-diol (E-[123I]NIVE)

We have synthesized and evaluated E-11beta-nitrato-17alpha-iodovinylestradiol (E-NIVE; E-3c) and its 123I-labelled form, as a new potential radioligand for imaging of estrogen receptor (ER)-positive human breast tumors. E-[123I]NIVE was prepared by stereospecific iododestannylation of the E-tri-n-butylstannylvinyl precursor (E-2c), obtained from reaction of 11beta-nitrato-estrone (8) with E-tributylstannylvinyllithium. In competitive binding studies, E-NIVE proved to have high binding affinity for both the rat and the human ER (Ki 280-730 pM), without significant binding to human sex hormone binding globulin. Distribution studies in normal and mammary tumor-bearing rats showed specific ER-mediated uptake of E-[123I]NIVE in the estrogen target tissues, i.e., uterus, ovaries, pituitary, and hypothalamus, but not in the mammary tumors. Selective retention in these target tissues, including tumor tissue, resulted in significant increases over time for the target tissue-to-muscle uptake ratios, but not for the target tissue-to-fat uptake ratios. The tumor-to-fat uptake ratio even appeared constantly below 1. In the primary estrogen target tissues, E-[123I]NIVE displayed high specific ER-mediated uptake and retention, which resulted in moderate target-to-nontarget tissue uptake ratios. In contrast, in tumor tissue, E-[123I]NIVE uptake appeared to be rather low and not ER-specific. As a consequence, E-[123I]NIVE appears to be a less favorable radioligand for ER imaging in breast cancer than the previously studied stereoisomers of 11beta-methoxy-17alpha-[123I]iodovinylestradiol (E- and Z-[123I]MIVE; [123I]E- and [123I]Z-3b).     

Iodine-123 labelled nor-beta-CIT binds to the serotonin transporter in vivo as assessed by biodistribution studies in rats

Flavobacterium aurantiacum NRRL B-184 possesses the ability to degrade aflatoxin B1 in solution and in several food items. Aflatoxin B1 is a potent carcinogen that causes significant economic losses to the agricultural and food industry. The role of trace metal ions (Cu2+, Mn2+, Zn2+, and Co2+) were studied in an effort to understand the enzymatic system involved in aflatoxin B1 degradation by F aurantiacum. The effect of divalent chelators (EDTA and 1,10-phenanthroline [OPT]) in the presence of the trace metal ions was studied as well. Aflatoxin B1 (10 microg/ml) was added to 72-h cultures of F aurantiacum that had been washed and resuspended in phosphate buffer (pH 7.0). HPLC was used to determine aflatoxin B1 concentration in these cultures. Incubating cells at 30 degrees C with 1 and 10 mM Cu2+, Mn2+, and Zn2+ significantly decreased aflatoxin B degradation after 4 and 24 h (P < 0.05). Decreased degradation was also observed with 1 and 10 mM Cu2+ and Zn2+ after 48 h and with 0.1 mM Cu2+ after 24 and 48 h. Co2+ did not have a significant effect on aflatoxin B1 degradation. EDTA and OPT did not counter the inhibition in the presence of Cu2+. The addition of 1 mM EDTA countered the inhibition by 1 mM Mn2+ after 4 and 24 h, but 1 mM OPT did not counter the inhibition by 10 mM Mn2+ after 4 and 24 h. OPT countered the inhibition by 1 mM Zn2+ after 4 and 48 h. These trace elements inhibit aflatoxin B1 degradation by F aurantiacum. In addition, their presence necessitates higher concentrations (>1 mM) of EDTA and OPT for the removal of their inhibitory effect.     

Assessing the usefulness of bibliometric indicators for the humanities and the social and beha vioural sciences: A comparative study

An evaluation was made of the use of bibliometric indicators for five disciplines in the humanities (social history, general linguistics, general literature, Dutch literature, and Dutch language) and three disciplines in the social and behavioural sciences (experimental psychology, anthropology, and public administration) in the Netherlands. Articles in journals were the predominant outlet in all disciplines. Monographs and popularizing articles were more important outlets in softer fields than in harder ones. The enlightenment function of scholarship was especially evident in Dutch literature and language, and public administration. Only some of the humanities disciplines are locally oriented. Although many publications were written in English, only experimental psychology, general linguistics, anthropology, and genrral literature were internationally oriented regarding output media. The impact of departments differed greatly both within and between disciplines. For all disciplines, bibliometric indicators are potentially useful for monitoring international impact, as expert interviews confirmed. Especially in Dutch language, Dutch literature and public administration, ISI-citation data are not very useful for monitoring national impact.     

Reliability of phase-velocity measurements of tibial bone

BACKGROUND AND PURPOSE: The Bone Stiffness Measurement Device-Swing is capable of measuring the propagation velocity of flexural waves in human tibial bone, which relates to bending stiffness. If the interrater and intrarater reliability of measurements obtained with the device are established, it can be used with confidence in assessing changes in bone. The purposes of this study were to detect potential sources of measurement error and to establish the interrater and intrarater reliability of measurements taken with the device. SUBJECTS AND METHODS: In the first part of the study, a random-effects design was used to obtain phase-velocity measurements in subjects without known orthopedic or neurological impairments. The second part of the study consisted of possible applications of the device with mixed designs on subjects with spinal cord injuries. By means of generalizability theory, multiple sources of error (eg, occasion, clinician, repetition) were estimated. For the clinical trial, 17 persons with spinal cord injuries not older than 5 weeks were tested. RESULTS: The standard error of measurement (SEM) for intrarater reliability measurements ranged from 7.3 to 9.8 m x s(-1) . The SEMs for interrater reliability measurements ranged from 5.7 to 9.5 m x s(-1). The SEMs for measurements obtained by a single clinician in a clinical population ranged from 11.9 to 39.7 m x s(-1). CONCLUSION AND DISCUSSION: The reproducibility of measurements obtained with the device is suitably high for the device to be used for evaluation in clinical and research settings.     

Stability of a layer of liquid flowing down an inclined plane

Summary The stability of the flow down an inclined plane is studied for small angles of inclination β. The same problem has been studied by S. P. Lin, however using an incorrect boundary condition. The correctly formulated eigenvalueproblem is solved by a numerical integration of the Orr-Sommerfeld equation employing the orthonormalization technique. It is shown that in the range 3′<β<1° a decrease in β means a decrease in the critical Reynolds number for the hard mode, which is a shear wave modified by the presence of the free surface. In that range the stability is still more or less governed by the stability of the soft waves, which are essentially surface waves modified by the presence of shear. For values of β<1′ the stability is governed by the hard mode, contradictory to Lin's statements. In that case instability occurs at high Reynolds numbers.     

Surface Temperature Test Methods Per IEEE 1349

The fine print note (FPN) No. 1 in 2005 National Electrical Code (NEC) Article 501.8 (B) [ANSI/NFPA 70, National Electrical Code, 2005 (NEC)] cautions users to "consider the temperature of internal and external surfaces that may be exposed to the flammable atmosphere" when putting a motor into service in a Class I, Division 2 environment. Thus, it is critical that manufacturers and users of industrial electric motors understand that internal peak temperatures exceed the external peak temperatures. This paper presents three common IEEE 1349 [IEEE 1349-2001, IEEE Guide for the Application of Electric Motors in Class I, Division 2 Hazardous (Classified) Locations] test methods used by manufacturers to determine these internal peak temperatures. Potential test method error and the test results from the three test methods are also presented. IEEE 1349 provides only guidance when performing these test methods so this paper intends to provide additional clarification. The test motors presented in this paper are low voltage, ac induction, severe-duty, energy-efficient, totally enclosed fan-cooled motors commonly used in the "Petrochemical Industry."