Pathogenesis of Mycobacterium bovis infection in cattle

This paper reviews the pathogenesis of Mycobacterium bovis infection in cattle, focusing on aspects relating to the host rather than the organism. A broad concept of pathogenesis has been considered and information is presented on sources and routes of infection, as well as the immune responses and pathology. In addition, data is presented on the excretion of M. bovis from tuberculous cattle.     

Nanocellulose-Carboxymethylcellulose Electrolyte for Stable,High-Rate Zinc-Ion Batteries

Aqueous Zn ion batteries (ZIBs) are one of the most promising battery chemistries for grid-scale renewable energy storage. However, their application is limited by issues such as Zn dendrite formation and undesirable side reactions that can occur in the presence of excess free water molecules and ions. In this study, a nanocellulose-carboxymethylcellulose (CMC) hydrogel electrolyte is demonstrated that features stable cycling performance and high Zn²⁺ conductivity (26 mS cm⁻¹), which is attributed to the material's strong mechanical strength (≈70 MPa) and water-bonding ability. With this electrolyte, the Zn-metal anode shows exceptional cycling stability at an ultra-high rate, with the ability to sustain a current density as high as 80 mA cm⁻² for more than 3500 cycles and a cumulative capacity of 17.6 Ah cm⁻² (40 mA cm⁻²). Additionally, side reactions, such as hydrogen evolution and surface passivation, are substantially reduced due to the strong water-bonding capacity of the CMC. Full Zn||MnO₂ batteries fabricated with this electrolyte demonstrate excellent high-rate performance and long-term cycling stability (>500 cycles at 8C). These results suggest the cellulose-CMC electrolyte as a promising low-cost, easy-to-fabricate, and sustainable aqueous-based electrolyte for ZIBs with excellent electrochemical performance that can help pave the way toward grid-scale energy storage for renewable energy sources.     

A modular approach to learning manipulation strategies from human demonstration

Object manipulation is a challenging task for robotics, as the physics involved in object interaction is complex and hard to express analytically. Here we introduce a modular approach for learning a manipulation strategy from human demonstration. Firstly we record a human performing a task that requires an adaptive control strategy in different conditions, i.e. different task contexts. We then perform modular decomposition of the control strategy, using phases of the recorded actions to guide segmentation. Each module represents a part of the strategy, encoded as a pair of forward and inverse models. All modules contribute to the final control policy; their recommendations are integrated via a system of weighting based on their own estimated error in the current task context. We validate our approach by demonstrating it, both in a simulation for clarity, and on a real robot platform to demonstrate robustness and capacity to generalise. The robot task is opening bottle caps. We show that our approach can modularize an adaptive control strategy and generate appropriate motor commands for the robot to accomplish the complete task, even for novel bottles.     

Boundary cell-based acceleration for volume ray casting

Several effective acceleration techniques for volume rendering offer efficient means to skip over empty space, providing significant speedup without affecting image quality. The effectiveness of such an approach depends on its ability to accurately estimate the object boundary inside a volume with minimal computational overhead. We propose a novel boundary cell-based acceleration technique for ray casting which skips over empty space by accurately calculating the intersection distance for each ray. Very short distance estimation time is achieved by exploiting a projection template to calculate the parallel-projection values of each boundary cell and the coherency of adjacent cells. Since no hardware acceleration is used, the projection procedure can also be efficiently parallelized. Experimental results are provided to demonstrate the performance of our new algorithm.     

The Literacy Myth in the Digital Archive of Literacy Narratives

One of the central endeavors in contemporary literacy studies is to interrogate traditional definitions of literacy and deconstruct literacy myths. The Digital Archive of Literacy Narratives (DALN), a publicly accessible online repository for literacy narratives, implicates itself in this effort. This essay examines instantiations of the literacy myth within literacy narratives and the archive itself. An analysis of the content and design of the DALN offers insight into how the archive provides contributors both subversive and traditional frameworks for understanding literacy and literacy narratives. Then an examination of three digital literacy narratives in the DALN demonstrates how a combination of narrative analytics can be directed towards revealing constructions of the literacy myth in the telling and meaning-making of individual lives.     

Choice of GP: who do young rural women prefer?

A community-based interdisciplinary health professions education project, involving the Colleges of Medicine, Nursing and Public and Allied Health, was implemented at the undergraduate level at East Tennessee State University from 1990 to the present. The outcomes of this project and the extension of the project into graduate health profession programs are described. Committed leadership, effective communication, and genuine community involvement are identified as essential to the success of community-based, interdisciplinary health professions training programs.     

Response of Building Adjacent to Stiff Excavation Support System in Soft Clay

A three-story school supported by shallow foundations was affected by an adjacent 12.2-m-deep excavation in soft clay in which the excavation support system was a 0.9-m-wide secant pile wall braced by both cross-lot struts and tiebacks. The school is a reinforced concrete frame structure with exterior reinforced concrete foundation walls. This paper summarizes the conditions at the site and presents correlations among construction activities, measured deformations and distortions, and attendant damage in the school. The lateral ground movements associated with the excavation were monitored with four inclinometers placed around the school. The building movements were monitored with optical survey points established on interior columns, exterior walls and on the roof, and with tiltmeters installed on the exterior foundation walls. The damage to the school mainly consisted of 300 to 500-mm-long hairline cracks in nonload bearing walls. Only a few cracks had widths greater than 6 mm. The school deformed such that the portion closest to the excavation sagged and the remainder hogged. Damage was first observed in the area of sagging when angular distortions reached 1/940 and the excavation was approximately 5.5-m deep. Angular distortions as large as 1/300 were observed at the end of the project. The data suggest that angular distortions had to be less than 1/1000 to preclude any damage to the school.     

Responses of lactating Holstein cows to chilled drinking water in high ambient temperatures

In Experiment 1, 12 lactating Holstein cows were provided drinking water of either 10.6 or 27.0 degrees C for 24 h/d in a changeover design to examine the effects of water temperature on feed intake, water intake, respiration rate, rectal temperature, plasma thyroid hormone concentration, and milk yield. The 1st wk of each 3-wk treatment period was for adjustment and the next 2 wk were comparison periods. Least squares means for DM intake as a percentage of body weight were 3.68 and 3.57 for 10.6 and 27.0 degrees C treatment groups. Water intakes in liters per kilogram of dry feed consumed as a percentage of body weight were 21.3 and 20.3. Respiration rates were 70.5 and 81.0 breaths per minute; rectal temperatures were 39.7 and 39.9 degrees C, Triiodothyronine averaged .88 and .75 ng/ml; thyroxine, 42.4 and 39.2 ng/ml; cortisol, 3.03 and 2.06 ng/ml; and progesterone in milk, 4.58 and 3.15 ng/ml for the 10.6 and 27.0 degrees C treatment groups. Milk yield averaged 25.9 and 24.7 kg/d and FCM averaged 25.6 and 23.6 kg/d, respectively. In Experiment 2, 24 cows given a choice of chilled or warm water showed a clear preference (about 98%) for the warm water. If cows are given chilled water of 10 degrees C continuously, no warm drinking water should be available. Chilled drinking water lowered respiration rates and body temperatures and increased feed intake and milk yield.     

Fate of endogenous steroid hormones in steer feedlots under simulated rainfall-induced runoff

Steroid hormones pose potential risks to fish and other aquatic organisms at extremely low concentrations. To assess the factors affecting the release of endogenous estrogenic and androgenic steroids from feedlots during rainfall, runoff, and soil samples were collected after simulated rainfall on a 14-steer feedlot under different rainfall rates and aging periods and analyzed for six steroid hormones. While only 17α-estradiol, testosterone, and progesterone were detected in fresh manure, 17β-estradiol, estrone, and androstenedione were present in the surficial soil after two weeks. In the feedlot surficial soil, concentrations of 17α-estradiol decreased by approximately 25% accompanied by an equivalent increase in estrone and 17β-estradiol. Aging of the feedlot soils for an additional 7 days had no effect on estrogen and testosterone concentrations, but androstenedione concentrations decreased substantially, and progesterone concentrations increased. Androstenedione and progesterone concentrations in the surficial soil were much higher than could be accounted for by excretion or conversion from testosterone, suggesting that other potential precursors, such as sterols, were converted after excretion. The concentration of androgens and progesterone in the soil were approximately 85% lower after simulated rainfall, but the estrogen concentrations remained approximately constant. The decreased masses could not be accounted for by runoff, suggesting the possibility of rapid microbial transformation upon wetting. All six steroids in the runoff, with the exception of 17β-estradiol, were detected in both the filtered and particle-associated phases at concentrations well above thresholds for biological responses. Runoff from the aged plots contained less 17α-estradiol and testosterone, but more estrone, androstenedione, and progesterone relative to the runoff from the unaged plots, and most of the steroids had a lower particle-associated fraction.