European diversity in science and technology

A clear understanding of the concept and consequences of diversity in science and technology is a key issue for Europe, when considering the current debate on cohesion Put forward within the Single European Act. According to Article 130B of the Single Act, all European policies, including technological policies must contribute to the achievement of a greater cohesion throughout the EC. The European market is generally presented as mainly a patchwork of national or even regional characteristics, with compartmentalized niches, and specific regulations. But does cohesion mean decreasing disparities between regions, which in such case signifies a passive policy of reallocation of resources within the EC, at the risk of generating uniformity? Or, does cohesion mean integration of all innovative and creative efforts, which implies a more complex policy of stimulation, under the condition to maintain a certain diversity? Must the governments systematically reduce diversity, or on the contrary must they enlarge diversity? How can they distinguish between negative and positive aspects of diversity? How do they operate a trade off between economies of scale and economies of diversity? To try to answer these political issues and to set up a coherent industrial policy at the EC level, a careful analysis of the sources of diversity, of the mechanisms that generate or reduce diversity, of the ways to valorize diversity are discussed in this paper     

Polyimide foams from powder: Experimental analysis of competitive diffusion phenomena

In the present study, various diffusive processes have been investigated during foaming of powdered precursors of polyimide. A detailed analysis of the powdered precursor's characteristics allows for an enhanced morphological understanding of the resulting microstructures and foam unit cell. Parameters that are central to the foaming process such as particle morphology, volatile concentration and sorption-desorption processes are evaluated. Isothermal and non-isothermal desorption experiments have been carried out by thermogravimetric analysis (TGA), and specific diffusive processes have been correlated to thermodynamic and kinetic transitions by means of modulated differential scanning calorimetry (MDSC) of the corresponding materials. It was found that two primary fluxes of volatiles, one out of the external surface of the particles (responsible for volatile desorption) and the other into the growing bubble (responsible for vapor supersaturation inside the bubble) compete against each other creating a competitive scenario that becomes the controlling factor for potential inflation within the precursor particles.     

Optimal control of auxiliary heating of passive-solar-heated buildings

Previous papers have demonstrated that low-cost off-peak electricity can be used to provide auxiliary heating for a passive-solar-heated residence. This paper describes the development of optimal control strategies for the operation of this auxiliary heating system. The temperature in the residence throughout the day as determined by computer simulation is presented for several optimal and conventional control strategies. The optimal control strategies improved the temperature control in the building compared to the conventional strategies. All strategies were shown to depend heavily on weather prediction. Computer simulations showed that errors in weather prediction had a small effect on heating cost and a large effect on being able to maintain the desired indoor temperature.     

Relation between depressive symptoms and stressful life events in a sample of disadvantaged mothers.

The bidirectional relation between life events and self-reported depression was examined across a 1-year period. With Time 1 depression controlled, Time 2 stress accounted for an additional 10% of Time 2 depressive symptoms. Health-related stress, family violence, and financial stress at Time 2 predicted Time 2 depression after control for Time 1 depression. With Time 1 stress controlled, Time 2 depression accounted for 8% of the variance in Time 2 stress. Time 2 depression predicted Time 2 health-related stress, financial stress, household changes, spouse–partner stress, family violence stress, and substance abuse stress, controlling for each of these stressors at Time 1. The results describe a complex relation between stress and depression and suggest that the relation between stress and depression is moderated by the type of stress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Leaching of sulfidized chalcopyrite with H<Subscript>2</Subscript>SO<Subscript>4</Subscript>-NaCl-O<Subscript>2</Subscript>

The recovery of copper from chalcopyrite by leaching is complex not only due to the slow dissolution kinetics of this mineral in most aqueous media but also due to the production of solutions that are heavily contaminated with iron. On the contrary, the leaching of sulfidized chalcopyrite is very attractive because of a faster and more selective dissolution of copper compared to the leaching of the untreated chalcopyrite. In this work, the results of leaching in H₂SO₄-NaCl-O₂ solutions of sulfidized chalcopyrite concentrate are discussed. Experiments were carried out with chalcopyrite concentrates previously reacted with elemental sulfur at 375 °C for 60 minutes. The results showed that the concentration of chloride ions below 0.5 M, temperature, and leaching time are important variables for the extraction of Cu. On the other hand, Fe extraction was little affected by the same variables, remaining below 6 pct for all the experimental conditions tested. Microscopic observations of the leached particles showed that the elemental sulfur produced by the reaction does not form a coherent layer surrounding the particle, but rather concentrates in certain locations as large clusters. The leaching kinetics can be accurately described by a nonreactive core-shrinking rim topochemical expression for spherical particles 1 − (1 − 0.45X)^1/3=kt. The activation energy found was 76 kJ/mol for the range 85 °C to 100 °C.     

Usher Syndrome in the Inner Ear: Etiologies and Advances in Gene Therapy

Hearing loss is the most common sensory disorder with ~466 million people worldwide affected, representing about 5% of the population. A substantial portion of hearing loss is genetic. Hearing loss can either be non-syndromic, if hearing loss is the only clinical manifestation, or syndromic, if the hearing loss is accompanied by a collage of other clinical manifestations. Usher syndrome is a syndromic form of genetic hearing loss that is accompanied by impaired vision associated with retinitis pigmentosa and, in many cases, vestibular dysfunction. It is the most common cause of deaf-blindness. Currently cochlear implantation or hearing aids are the only treatments for Usher-related hearing loss. However, gene therapy has shown promise in treating Usher-related retinitis pigmentosa. Here we review how the etiologies of Usher-related hearing loss make it a good candidate for gene therapy and discuss how various forms of gene therapy could be applied to Usher-related hearing loss.     

Effect of Aluminum Content on the Dynamic Recrystallization of Fe18MnxAl0.74C Steels During Hot-Forging Treatments

Metallurgical and Materials Transactions A - In the present work, the dynamic recrystallization and microstructural evolution of the family of advanced high-strength steels Fe18MnxAl0.74C are...     

Improving class probability estimates for imbalanced data

Obtaining good probability estimates is imperative for many applications. The increased uncertainty and typically asymmetric costs surrounding rare events increase this need. Experts (and classification systems) often rely on probabilities to inform decisions. However, we demonstrate that class probability estimates obtained via supervised learning in imbalanced scenarios systematically underestimate the probabilities for minority class instances, despite ostensibly good overall calibration. To our knowledge, this problem has not previously been explored. We propose a new metric, the stratified Brier score, to capture class-specific calibration, analogous to the per-class metrics widely used to assess the discriminative performance of classifiers in imbalanced scenarios. We propose a simple, effective method to mitigate the bias of probability estimates for imbalanced data that bags estimators independently calibrated over balanced bootstrap samples. This approach drastically improves performance on the minority instances without greatly affecting overall calibration. We extend our previous work in this direction by providing ample additional empirical evidence for the utility of this strategy, using both support vector machines and boosted decision trees as base learners. Finally, we show that additional uncertainty can be exploited via a Bayesian approach by considering posterior distributions over bagged probability estimates.     

Superposition of the notched strength of composite laminates

An improved macroscopic model for predicting the strength of a composite laminate containing a circular notch is developed. Two constants are introduced which uniquely determine the notch sensitivity of a given material. A superposition method for the notched strength of composite laminates is developed which allows data for arbitrary materials and laminate configurations to be superimposed upon a single master curve. The influence of material orthotropy upon notched strength is discussed. A relative notch sensitivity parameter is introduced which allows quantification of the notch sensitivity of a given composite material system, stacking sequence, or laminate configuration.