Reconstructing gene regulatory networks with a memetic-neural hybrid based on fuzzy cognitive maps

Reconstructing gene regulatory networks (GRNs) plays an important role in identifying the complicated regulatory relationships, uncovering regulatory patterns in cells, and gaining a systematic view for biological processes. In order to reconstruct large-scale GRNs accurately, in this paper, we first use fuzzy cognitive maps (FCMs), which are a kind of cognition fuzzy influence graphs based on fuzzy logic and neural networks, to model GRNs. Then, a novel hybrid method is proposed to reconstruct GRNs from time series expression profiles using memetic algorithm (MA) combined with neural network (NN), which is labeled as MANN_FCM-GRN. In MANN_FCM-GRN, the MA is used to determine regulatory connections in GRNs and the NN is used to determine the interaction strength of the regulatory connections. In the experiments, the performance of MANN_FCM-GRN is validated on both synthetic data and the benchmark dataset DREAM3 and DREAM4. The experimental results demonstrate the efficacy of MANN_FCM-GRN and show that MANN_FCM-GRN can reconstruct GRNs with high accuracy without expert knowledge. The comparison with existing algorithms also shows that MANN_FCM-GRN outperforms ant colony optimization, non-linear Hebbian learning, and real-coded genetic algorithms.

     

烟道流量计量标准装置

为了解决我国烟道流量计的量值溯源问题,中国计量科学研究院建立了烟道流量计量标准装置。装置使用可溯源至标准转盘的激光多普勒测速仪作为原级标准器,采用激光多普勒流速剖面扫描和超声流量计波动修正的方式测量标准流量,经校准的8声道超声流量计为工作级标准表,具备了908~104840m3/h的测量能力,扩展不确定度为0.62%(k=2),可对最大口径为1m的流量计进行校准。装置下游测试段包括圆形管段和矩形管段,能够开展烟道流量计测量性能的研究。     

Visual Detection of Adenosine Triphosphate by Taylor Rising: A Simple Point-of-Care Testing Method Based on Rolling Circle Amplification

Rapid and sensitive point-of-care testing (POCT) is an extremely critical mission in practical applications, especially for rigorous military medicine, home health care, and in the third world. Here, we report a visual POCT method for adenosine triphosphate (ATP) detection based on Taylor rising in the corner of quadratic geometries between two rod surfaces. We discuss the principle of Taylor rising, demonstrating that it is significantly influenced by contact angle, surface tension, and density of the sample, which are controlled by ATP-dependent rolling circle amplification (RCA). In the presence of ATP, RCA reaction effectively suppresses Taylor-rising behavior, due to the increased contact angle, density, and decreased surface tension. Without addition of ATP, untriggered RCA reaction is favorable for Taylor rising, resulting in a significant height. With this proposed method, visual sensitive detection of ATP without the aid of other instruments is realized with only a 5 μL droplet, which has good selectivity and a low detection limit (17 nM). Importantly, this visual method provides a promising POCT tool for user-friendly molecular diagnostics.     

家庭网络的业务和技术详述

首先分析了家庭网络的具体业务和应用．然后详细介绍了家庭网络涉及的各项关键技术。     

广东省智能网工程建设

本文介绍了广东省智能网的组网方案及所能提供的业务,并论述了智能网工程建设,安装维护以及与广东省现有移动通信网联网中存在的一些问题。     

用于光城域网的新型RPR技术

介绍IEEE802.17正在进行标准化的弹性分组环(RPR,Resilient Packet Ring)协议,分析其帧结构及主要功能特色,并和SDH与以太网等现有城域网技术作简要对比;可以预见,随着标准化工作的进行,综合多种传输技术优势的RPR会成为创建下一代高速光城域网的首选技术。     

Battery-Aware Routing for Streaming Data Transmissions in Wireless Sensor Networks

Recent technological advances have made it possible to support long lifetime and large volume streaming data transmissions in sensor networks. A major challenge is to maximize the lifetime of battery-powered sensors to support such transmissions. Battery, as the power provider of the sensors, therefore emerges as the key factor for achieving high performance in such applications. Recent study in battery technology reveals that the behavior of battery discharging is more complex than we used to think. Battery powered sensors might waste a huge amount of energy if we do not carefully schedule and budget their discharging. In this paper we study the effect of battery behavior on routing for streaming data transmissions in wireless sensor networks. We first give an on-line computable energy model to mathematically model battery discharge behavior. We show that the model can capture and describe battery behavior accurately at low computational complexity and thus is suitable for on-line battery capacity computation. Based on this battery model we then present a battery-aware routing (BAR) protocol to schedule the routing in wireless sensor networks. The routing protocol is sensitive to the battery status of routing nodes and avoids energy loss. We use the battery data from actual sensors to evaluate the performance of our protocol. The results show that the battery-aware protocol proposed in this paper performs well and can save a significant amount of energy compared to existing routing protocols for streaming data transmissions. Network lifetime is also prolonged with maximum data throughput. As far as we know, this is the first work considering battery-awareness with an accurate analytical on-line computable battery model in sensor network routing. We believe the battery model can be used to explore other energy efficient schemes for wireless networks as well.