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Substantial evidence indicates that bisphenol A (BPA), a ubiquitous environmental chemical used in the synthesis of polycarbonate plastics and epoxy resins, can impair brain development. Clinical and epidemiological studies exploring potential connections between BPA and neurodevelopmental disorders in humans have repeatedly identified correlations between early BPA exposure and developmental disorders, such as attention deficit/hyperactivity disorder and autism spectrum disorder. Investigations using invertebrate and vertebrate animal models have revealed that developmental exposure to BPA can impair multiple aspects of neuronal development, including neural stem cell proliferation and differentiation, synapse formation, and synaptic plasticity—neuronal phenotypes that are thought to underpin the fundamental changes in behavior-associated neurodevelopmental disorders. Consistent with neuronal phenotypes caused by BPA, behavioral analyses of BPA-treated animals have shown significant impacts on behavioral endophenotypes related to neurodevelopmental disorders, including altered locomotor activity, learning and memory deficits, and anxiety-like behavior. To contextualize the correlations between BPA and neurodevelopmental disorders in humans, this review summarizes the current literature on the developmental neurotoxicity of BPA in laboratory animals with an emphasis on neuronal phenotypes, molecular mechanisms, and behavioral outcomes. The collective works described here predominantly support the notion that gestational exposure to BPA should be regarded as a risk factor for neurodevelopmental disorders. 相似文献
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Jon R Saunders Heather Allison Chloe E James Alan J McCarthy Richard Sharp 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2001,76(7):662-666
Bacteriophages as accessory genetic elements play a crucial role in the dissemination of genes and the promotion of genetic diversity within bacterial populations. Such horizontal transfer of DNA is critical in the emergence of new pathogenic organisms, through the dissemination of genes encoding virulence factors such as toxins, adhesins and agressins. Phages can transfer genes that are not necessary for bacteriophage persistence and are generally recognised by their ability to convert their host bacteria to new phenotypes. This phenomenon is known as phage conversion. If such converting genes encode for virulence factors, the consequences of phage infection may include increased virulence of the host bacteria, and the conversion of a non‐pathogenic strain to a potentially dangerous pathogen. A number of virulence factors in bacteria causing diseases in plants, animals and humans are encoded by converting phages, the vast majority of which are temperate as opposed to lytic in nature. © 2001 Society of Chemical Industry 相似文献
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The mechanism underlying outward chloride transport in the cell body and in the neuritic field of cockroach Dorsal Unpaired Median (DUM) neurones was assessed using the intracellular microelectrode technique. The chloride equilibrium potential was indirectly estimated from the reversal potentials of responses to gamma-aminobutyric acid (GABA) pressure ejections and of inhibitory postsynaptic potential (IPSP) evoked by electrical stimulation of the anterior connectives. Changes in intracellular chloride concentration [Cl-]i following various treatments were estimated from the amplitude changes of soma GABA responses and IPSP. Decreasing external Cl- concentration reduced the amplitude of GABA-mediated inhibitory events without affecting the membrane potential. Cl-/K+ co-transport was assessed by increasing external K+ concentration. The rate of outward Cl- movement was reduced furosemide but not by SITS or DIDS. All these results suggest that Cl- is not passively distributed in DUM neurones and that an active outwardly directed Cl-/K+ co-transport is implicated in the regulation of [Cl-]i. 相似文献
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This paper looks at the intersections between feminist epistemology, feminist jurisprudence and research on artificial intelligence and the law. It is suggested that feminist theory highlights the role of subjectivity which is ignored in the traditional epistemology of AI systems. This allows AI systems to appear to be “perspectiveless” when they may be tacitly used in a normative role which ignores alternative knowledges. The paper looks at the Cyc system as an example. In developing an expert system to advise on Sex Discrimination law a number of lessons are learned both from the Forms Helper system and more particularly from feminist jurisprudence and from the critique of AI from feminist epistemology. 相似文献
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Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice
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Chloe Dubreil Odile Sainte Catherine Yoann Lalatonne Clément Journé Phalla Ou Peter van Endert Laurence Motte 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(40)
Nanoparticle (NP) administration is among the most attractive approaches to exploit the synergy of different copackaged molecules for the same target. In this work, iron oxide NPs are surface‐engineered for the copackaging of the autoantigen proinsulin, a major target of adaptive immunity in type 1 diabetes (T1D), and 2‐(1′H‐indole‐3′‐carbonyl)‐thiazole‐4‐carboxylic acid methylester (ITE), a small drug conditioning a tolerogenic environment. Magnetic resonance imaging (MRI) combined with magnetic quantification are used to investigate NP biokinetics in nonobese diabetic (NOD) mice and control mice in different organs. Different NP biodistribution, with in particular enhanced kidney elimination and a stronger accumulation in the pancreas for prediabetic NOD mice, is observed. This is related to preferential NP accumulation in the pancreatic inflammatory zone and to enhancement of renal elimination by diabetic nephropathy. For both mouse strains, an MRI T2 contrast enhancement at 72 h in the liver, pancreas, and kidneys, and indicating recirculating NPs, is also found. This unexpected result is confirmed by magnetic quantification at different time points as well as by histological evaluation. Besides, such NPs are potential MRI contrast agents for early diagnosis of T1D. 相似文献
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Béatrice Daille Estelle Dubreil Laura Monceaux Matthieu Vernier 《Language Resources and Evaluation》2011,45(4):409-437
The blog phenomenon is universal. Blogs are characterized by their evaluative use, in that they enable Internet users to express
their opinion on a given subject. From this point of view, they are an ideal resource for the constitution of an annotated
sentiment analysis corpus, crossing the subject and the opinion expressed on this subject. This paper presents the Blogoscopy
corpus for the French language which was built up with personal thematic blogs. The annotation was governed by three principles:
theoretical, as opinion is grounded in a linguistic theory of evaluation, practical, as every opinion is linked to an object,
and methodological as annotation rules and successive phases are defined to ensure quality and thoroughness. 相似文献
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Dr. Rhushikesh A. Kulkarni Chloe A. Briney Dr. Daniel R. Crooks Sarah E. Bergholtz Dr. Chandrasekhar Mushti Dr. Stephen J. Lockett Dr. Andrew N. Lane Dr. Teresa W.-M. Fan Dr. Rolf E. Swenson Dr. W. Marston Linehan Dr. Jordan L. Meier 《Chembiochem : a European journal of chemical biology》2019,20(3):360-365
Dysregulated metabolism can fuel cancer by altering the production of bioenergetic building blocks and directly stimulating oncogenic gene-expression programs. However, relatively few optical methods for the direct study of metabolites in cells exist. To address this need and facilitate new approaches to cancer treatment and diagnosis, herein we report an optimized chemical approach to detect the oncometabolite fumarate. Our strategy employs diaryl tetrazoles as cell-permeable photoinducible precursors to nitrileimines. Uncaging these species in cells and cell extracts enables them to undergo 1,3-dipolar cycloadditions with endogenous dipolarophile metabolites such as fumarate to form pyrazoline cycloadducts that can be readily detected by their intrinsic fluorescence. The ability to photolytically uncage diaryl tetrazoles provides greatly improved sensitivity relative to previous methods, and enables the facile detection of dysregulated fumarate metabolism through biochemical activity assays, intracellular imaging, and flow cytometry. Our studies showcase an intersection of bioorthogonal chemistry and metabolite reactivity that can be applied for biological profiling, imaging, and diagnostics. 相似文献
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Patterns of stability in adult attachment: An empirical test of two models of continuity and change.
Fraley R. Chris; Vicary Amanda M.; Brumbaugh Claudia Chloe; Roisman Glenn I. 《Canadian Metallurgical Quarterly》2011,101(5):974
One of the core assumptions of attachment theory is that attachment representations are stable over time. Unfortunately, the data on attachment stability have been ambiguous, and as a result, alternative theoretical perspectives have evolved to explain them. The objective of the present research was to evaluate alternative models of stability by studying adults in 2 intensive longitudinal investigations. Specifically, we assessed attachment representations in 1 sample (N = 203) daily over a 30-day period and in the other sample (N = 388) weekly over a year. Analyses show that the patterns of stability that exist in adult attachment are most consistent with a prototype model—a model assuming that there is a stable factor underlying temporary variations in attachment. Moreover, although the Big Five personality traits exhibited a pattern of stability that was similar to that of attachment, they did not account for the stability observed in attachment. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
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Mei‐Yung Leung Paul Olomolaiye Alice Chong Chloe C. Y. Lam 《Construction Management & Economics》2013,31(9):891-903
Cost estimation not only requires precise technical and analytical input from estimators but also involves the use of subjective judgement. An investigation on the impact of stress on estimation performance was conducted involving 177 professional estimators in Hong Kong. Using correlation analysis, regression analysis and structural equation modelling, the relationships between stress and various aspects of estimation performance are examined and a causal structural model is developed. The results indicate that stress is a cause of negative estimation performance (resulting in weak interpersonal relationships, unfamiliarity with organization and ineffective process), while, simultaneously, it is beneficial to the professional estimation performance. Furthermore, there is an inverted U‐shaped relationship between stress and the organizational relationship. 相似文献