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Summary The uniqueness of some helical flows of a second grade fluid, between two infinite circular cylinders, is proved. Initially, the fluid is at rest and flow is produced by the motion of the cylinders. Finally, the special case of a flow in a circular cylinder is considered. 相似文献
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Gianmarco de Felice Maria Antonietta Aiello Carmelo Caggegi Francesca Ceroni Stefano De Santis Enrico Garbin Natalino Gattesco Łukasz Hojdys Piotr Krajewski Arkadiusz Kwiecień Marianovella Leone Gian Piero Lignola Claudio Mazzotti Daniel Oliveira Corina Papanicolaou Carlo Poggi Thanasis Triantafillou Maria Rosa Valluzzi Alberto Viskovic 《Materials and Structures》2018,51(4):95
Textile Reinforced Mortar (TRM), also known as Fabric Reinforced Mortar or Fabric Reinforced Cementitious Matrix, composites are an emerging technology for the external repair and strengthening of existing structures. For most applications, the effectiveness of the TRM reinforcement relies on its bond performance. This recommendation identifies the best practice to characterize the bond behaviour of TRM. A shear bond test method is proposed to determine the peak axial stress (associated with the maximum load that can be transferred from the structural member to the externally bonded TRM reinforcement), the stress–slip relationship and the failure mode that controls the TRM-to-substrate load transfer capacity. Guidelines on specimen manufacturing, experimental setup, test execution, and determination of test results are provided. 相似文献
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Exact solutions corresponding to the motions of a second grade fluid, due to the cosine and sine oscillations of an infinite flat plate as well as those induced by an oscillating pressure gradient are determined by means of the Fourier sine transforms. These solutions, presented as sum of the steady-state and transient solutions, satisfy both the governing equations and all associate initial and boundary conditions. In the special case when α1 → 0, they reduce to those for a Navier-Stokes fluid. 相似文献
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This paper attempts to unify some of the existing approaches to defining modal logics for coalgebras, from the point of view of constructing the languages employed by these logics. An abstract framework for defining languages for coalgebras from so-called language constructors, corresponding to one-step unfoldings of the coalgebraic structure, is introduced, and a method for deriving expressive languages for coalgebras from suitable choices for the language constructors is described. Moreover, it is shown that the derivation of such languages by means of language constructors is well-behaved w.r.t. various forms of composition between coalgebraic types. 相似文献
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Codruta Soica Corina Danciu Germaine Savoiu-Balint Florin Borcan Rita Ambrus Istvan Zupko Florina Bojin Dorina Coricovac Sorina Ciurlea Stefana Avram Cristina Adriana Dehelean Teodora Olariu Petru Matusz 《International journal of molecular sciences》2014,15(5):8235-8255
Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and scanning electron microscopy (SEM) methods and then in vitro tested for its antiproliferative activity by the MTT assay and by cell cycle analysis. Finally, the complex was tested in vivo using an animal model of murine melanoma developed in C57BL/6J mice, where it caused a reduction in tumor volume and weight. The study revealed the beneficial influence of betulinic acid inclusion into the cyclodextrin in terms of antiproliferative activity and in vivo tumor development. 相似文献
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Characterization of Chemically and Thermally Treated Oil‐in‐Water Heteroaggregates and Comparison to Conventional Emulsions
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Heteroaggregated oil‐in‐water (O/W) emulsions formed by targeted combination of oppositely charged emulsion droplets were proposed to be used for the modulation of physical properties of food systems, ideally achieving the formation of a particulate 3‐dimensional network at comparably low‐fat content. In this study, rheological properties of Quillaja saponins (QS), sugar beet pectin (SBP), and whey protein isolate (WPI) stabilized conventional and heteroaggregated O/W emulsions at oil contents of 10% to 60% (w/w) were investigated. Selected systems having an oil content of 30% (w/w) and different particle sizes (d43 ≤ 1.1 or ≥16.7 μm) were additionally subjected to chemical (genipin or glutaraldehyde) and thermal treatments, aiming to increase network stability. Subsequently, their rheological properties and stability were assessed. Yield stresses (τ0) of both conventional and heteroaggregated O/W emulsions were found to depend on emulsifier type, oil content, and initial droplet size. For conventional emulsions, high yield stresses were only observed for SBP‐based emulsions (τ0,SBP approximately 157 Pa). Highest yield stresses of heteroaggregates were observed when using small droplets stabilized by SBP/WPI (approximately 15.4 Pa), being higher than those of QS/WPI (approximately 1.6 Pa). Subsequent treatments led to significant alterations in rheological properties for SBP/WPI systems, with yield stresses increasing 29‐fold (glutaraldehyde) and 2‐fold (thermal treatment) compared to untreated heteroaggregates, thereby surpassing yield stresses of similarly treated conventional SBP emulsions. Genipin‐driven treatments proved to be ineffective. Results should be of interest to food manufacturers wishing to design viscoelastic food emulsion based systems at lower oil droplet contents. 相似文献
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Flaviu Tma Rodica Blaa Doina Manu Gabriel Gyorki Rare Chinezu Corina Tma Adrian Blaa 《International journal of molecular sciences》2022,23(3)
Brain metastases represent more than 50% of all cerebral tumors encountered in clinical practice. Recently, there has been increased interest in the study of extracellular vesicles, and the knowledge about exosomes is constantly expanding. Exosomes are drivers for organotropic metastatic spread, playing important roles in the brain metastatic process by increasing the permeability of the blood–brain barrier and preparing the premetastatic niche. The promising results of the latest experimental studies raise the possibility of one day using exosomes for liquid biopsies or as drug carriers, contributing to early diagnosis and improving the efficacy of chemotherapy in patients with brain metastases. In this review, we attempted to summarize the latest knowledge about the role of exosomes in the brain metastatic process and future research directions for the use of exosomes in patients suffering from brain metastatic disease. 相似文献
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Paul-Mihai Boarescu Ioana Boarescu Raluca Maria Pop tefan Horia Roian Ioana Corina Bocan Vasile Rus Rzvan Olimpiu Mada Iulia Diana Popa Nicholas Neagu Adriana Elena Bulboac Anca Dana Buzoianu Sorana D. Bolboac 《International journal of molecular sciences》2022,23(3)
The present study aims to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors, namely, hypertension, dyslipidemia, and type 1 diabetes mellitus. Hypertension was induced with 40 mg/kg body weight (b.w.) of N omega-nitro-L-arginine-methyl (L-NAME) administered orally. Dyslipidemia was induced by the administration of a diet with a high cholesterol (2%) content. Diabetes mellitus was induced by intraperitoneal administration of a single dose of streptozocin (65 mg/kg). Malondialdehyde (MDA) and total oxidative status (TOS) are increased by all three cardiovascular risk factors (up to 207%). The indirect assessment of NO synthesis (NOx) is observed to be reduced after L-NAME administration (43%), and dyslipidemia induction (16%), while type 1 diabetes mellitus is associated with the highest levels of NOx (increased 112%). Hypertension, dyslipidemia, and type 1 diabetes reduced the total antioxidative capacity (TAC) and total thiol (SH) levels (up to 57%). The values of evaluated pro-inflammatory cytokines, tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), assessed from the ascending aorta were elevated by all three cardiovascular risk factors, with the highest levels induced by type 1 diabetes mellitus (up to 259%). The histopathological examination of the ascending and descending aorta revealed reversible pro-atherogenic changes consisting of the accumulation of lipid droplets in the subendothelial connective tissue on rats with hypertension and dyslipidemia. Irreversible pro-atherogenic changes consisting of a reduction of the specific elasticity of the arteries were observed in rats with type 1 diabetes mellitus. Type 1 diabetes mellitus demonstrates an alteration of the oxidative stress parameters, the elevation of tissue levels of the pro-inflammatory cytokines and causing irreversible pro-atherogenic changes on the aortic wall. 相似文献