Joint Effect of MLSE and Receiver Filters Optimization on Dispersion Robustness of IMDD, DPSK, DQPSK, and Duobinary Modulation

We analyze the effectiveness of a 32-state maximum-likelihood sequence-estimation (MLSE) receiver on chromatic dispersion robustness of optical transmission based on several binary modulation formats: intensity modulation direct detection, differential phase-shift keying, and duobinary line coding. Multilevel differential quadrature phase-shift keying modulation is also analyzed using a four-state 2-bit/symbol joint MLSE processor. For all modulation formats, receiver filters are optimized together with the use of the MLSE technique.     

Sorafenib delivery nanoplatform based on superparamagnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

Currently,sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients.Unfortunately,its side effects,particularly its overall toxicity,limit the therapeutic response that can be achieved.Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field,thus improving intratumoral accumulation and reducing adverse effects.Here,nanoformulations based on polyethylene glycol modified phospholipid micelles,loaded with both SPIONs and sorafenib,were successfully prepared and thoroughly investigated by complementary techniques.This nanovector system provided effective drug delivery,had an average hydrodynamic diameter of about 125 nm,had good stability in aqueous medium,and allowed controlled drug loading.Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle.An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver.Human hepatocellular carcinoma (HepG2) cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib.These experiments demonstrated that this delivery platform is able to enhance sorafenib's antitumor effectiveness by magnetic targeting.The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites,where selective release of sorafenib can improve its efficacy and safety profile.     

Electronic distortion compensation in the mitigation of optical transmission impairments: the view of joint project on mitigation of optical transmission impairments by electronic means ePhoton/ONe1 project

The key design approaches and results in the field of compensation of optical impairment distortion by electronic means, as an outcome of the studies and research innovations developed within the joint project on mitigation of optical transmission impairments by electronic means work group of the ePhoton/ONet European project are presented. The research topics addressed are related to chromatic and polarisation mode dispersion, with particular reference to feed-forward/decision-feedback equaliser and maximum-likelihood sequence estimation-based equalisers as well as pre-distortion schemes. Additionally, the use of electronic compensation in metro/access applications is examined with reference to studies related to the performance enhancement of directly modulated laser transmitters, the compensation of the square-law characteristics of receivers and the equalisation of multi-level format schemes.     

An Epoxy Photoresist Modified by Luminescent Nanocrystals for the Fabrication of 3D High‐Aspect‐Ratio Microstructures

An epoxy‐based negative‐tone photoresist, which is known as a suitable material for high‐aspect‐ratio surface micromachining, is functionalized with red‐light‐emitting CdSe@ZnS nanocrystals (NCs). The proper selection of a common solvent for the NCs and the resist is found to be critical for the efficient incorporation of the NCs in the epoxy matrix. The NC‐modified resist can be patterned by standard UV lithography down to micrometer‐scale resolution, and high‐aspect‐ratio structures have been successfully fabricated on a 100 mm scaled wafer. The “as‐fabricated”, 3D, epoxy‐based surface microstructures show the characteristic luminescent properties of the embedded NCs, as verified by fluorescence microscopy. This issue demonstrates that the NC emission properties can be conveniently conveyed into the polymer matrix without deteriorating the lithographic performance of the latter. The dimensions, the resolution, and the surface morphology of the NC‐modified‐epoxy microstructures exhibit only minor deviations with respect to that of the unmodified reference material, as examined by means of microscopic and metrologic investigations. The proposed approach of the incorporation of emitting and non‐bleachable NCs into a photoresist opens novel routes for surface patterning of integrated microsystems with inherent photonic functionality at the micro‐ and nanometer‐scale for light sensing and emitting applications.     

Optimization of Branch Metric Exponent and Quantization Range in MLSE Receivers for Duobinary Systems

We analyze by simulation the performance of an optically amplified uncompensated duobinary system using a 64-state maximum-likelihood sequence estimation (MLSE) receiver (Rx) based on a Euclidean branch metric with variable postdetection nonlinear distortion exponent. We found that the optimum exponent depends on the accumulated dispersion, the Rx analog-to-digital converter (ADC) resolution, and signal clipping. On the other hand, we found performance to be weakly dependent on the exponent value. When using a finite number of ADC resolution bits, drastic signal clipping proved very beneficial in improving the performance of the MLSE processor. Assuming three resolution bits, with joint clipping and exponent optimization, uncompensated transmission at 10.7 Gb/s over 550 km of standard single-mode fiber could be achieved with essentially no penalty with respect to back-to-back.     

A novel analytical approach to the evaluation of the impact offiber parametric gain on the bit error rate

We present in this paper a novel accurate method to analyze the performance of an optical link where the amplified spontaneous emission noise, enhanced by a fiber nonlinear phenomenon called parametric gain, is the limiting factor. Our method allows us to compute the exact error probability given a generic noise spectral density at the input of a direct detection optical receiver, using arbitrary optical and electrical filters. We compare our results with those predicted using the standard Gaussian technique (based on the Q factor), showing that this approximation may lead to significant errors. Our method is then used to evaluate the impact of parametric gain on a realistic long-haul multiwavelength link operating at 10 Gb/s, showing both the system limitation imposed by this phenomenon and the inaccuracy of the Q factor method     

A time-domain optical transmission system simulation packageaccounting for nonlinear and polarization-related effects in fiber

The fast-paced evolution of long-haul and high-bit-rate terrestrial and submarine optical transmission links requires powerful analysis tools that take into account all the relevant phenomena in the fiber. To provide such a tool, we developed a time-domain optical system simulation package, integrated in the TOPSIM simulation environment. The fiber simulation module makes use of the vector form of the propagation equations to account for the quasi-degenerate two-mode (the two polarizations) medium propagation characteristics. This way, all polarization-related effects and their interplay with the other linear and nonlinear phenomena in the fiber can be accurately modeled. In particular, the fiber third-order susceptivity, responsible for all major nonlinear effects, is expressed in its actual vector form, so that nonlinear polarization mode coupling could be accounted for. Conventional birefringence and PMD are generated using appropriate random models. A novel feature of the simulator is that it uses time-domain digital filters to simulate dispersion effects, as opposed to the usual FFT-based algorithms. This approach leads to more efficient computing for a wide range of bandwidth and dispersion values. We present the fiber simulation module in detail. As an example of the use of the simulation package, the analysis of a long-haul two-channel transoceanic WDM transmission system is presented     

Tuning light emission of PbS nanocrystals from infrared to visible range by cation exchange

Colloidal semiconductor nanocrystals, with intense and sharp-line emission between red and near-infrared spectral regions, are of great interest for optoelectronic and bio-imaging applications. The growth of an inorganic passivation layer on nanocrystal surfaces is a common strategy to improve their chemical and optical stability and their photoluminescence quantum yield. In particular, cation exchange is a suitable approach for shell growth at the expense of the nanocrystal core size. Here, the cation exchange process is used to promote the formation of a CdS passivation layer on the surface of very small PbS nanocrystals (2.3 nm in diameter), blue shifting their optical spectra and yielding luminescent and stable nanostructures emitting in the range of 700–850 nm. Structural, morphological and compositional investigation confirms the nanocrystal size contraction after the cation-exchange process, while the PbS rock-salt crystalline phase is retained. Absorption and photoluminescence spectroscopy demonstrate the growth of a passivation layer with a decrease of the PbS core size, as inferred by the blue-shift of the excitonic peaks. The surface passivation strongly increases the photoluminescence intensity and the excited state lifetime. In addition, the nanocrystals reveal increased stability against oxidation over time. Thanks to their absorption and emission spectral range and the slow recombination dynamics, such highly luminescent nano-objects can find interesting applications in sensitized photovoltaic cells and light-emitting devices.     

TiO(2) nanorods/PMMA copolymer-based nanocomposites: highly homogeneous linear and nonlinear optical material

Original nanocomposites have been obtained by direct incorporation of pre-synthesized oleic acid capped TiO(2) nanorods into properly functionalized poly(methyl methacrylate) copolymers, carrying carboxylic acid groups on the repeating polymer unit. The presence of carboxylic groups on the alkyl chain of the host functionalized copolymer allows an highly homogeneous dispersion of the nanorods in the organic matrix. The prepared TiO(2)/PMMA-co-MA nanocomposites show high optical transparency in the visible region, even at high TiO(2) nanorod content, and tunable linear refractive index depending on the nanoparticle concentration. Finally measurements of nonlinear optical properties of TiO(2) polymer nanocomposites demonstrate a negligible two-photon absorption and a negative value of nonlinear refractive index, highlighting the potential of the nanocomposite for efficient optical devices operating in the visible region.     

Modulation formats suitable for ultrahigh spectral efficient WDM systems

We analyze the performance of four different modulation formats in ultrahigh spectral efficient wavelength-division multiplexing (WDM) systems. Besides standard nonreturn-to-zero intensity modulation, we analyze duobinary, differential phase-shift keying (DPSK), and carrier-suppressed return-to-zero (CSRZ)-DPSK and, for each of them, optimize several system parameters, such as filtering and dispersion map. First, we optimize transmitter and receiver parameters in back-to-back condition, then we study the performance in a multispan scenario and its dispersion map optimization. Duobinary, DPSK, and CSRZ-DPSK show high suitability for ultrahigh spectral efficient WDM systems and high resilience to dispersion compensation tolerances and fiber nonlinearities. The investigation is based on detailed simulative analyses.