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In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria 下载免费PDF全文
Su Chul Jang Sae Rom Kim Yae Jin Yoon Kyong‐Su Park Ji Hyun Kim Jaewook Lee Oh Youn Kim Eun‐Jeong Choi Dae‐Kyum Kim Dong‐Sic Choi Yoon‐Keun Kim Jaesung Park Dolores Di Vizio Yong Song Gho 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(4):456-461
Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo. 相似文献
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Spinel LiSr0·1Cr0·1Mn1·8O4 was synthesised by high temperature solid state method in order to enhance the electrochemical performance. The LiSr0·1Cr0·1Mn1·8O4 (LSCMO) materials were characterised by X-ray diffraction (XRD), scanning electron microscopy (SEM) and electrochemical tests. The XRD and SEM studies confirm that LSCMO had spinel crystal structure with a space group of Fd3m, and the particle of LSCMO shows irregular shape. The cyclic voltammetry data illustrated that the heavy current charge–discharge performance of LMO was improved by Sr2+ and Cr3+ doping. The galvanostatic charge–discharge of LSCMO cathode materials was measured at 1, 5, 10 and 20 C. The results indicated that LSCMO improved the capacity retention. 相似文献
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通过对普查区喜山期玄武岩喷发分布范围、形态的分析,对燕山晚期闪长玢岩分布范围、与构造关系、对煤层的影响等方面的分析,阐述了太平普查区岩浆活动特征。 相似文献
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This paper presents a spatio-temporal fusion method for remote sensing images by using a linear injection model and local neighbourhood information. In this method, the linear injection model is first introduced to generate an initial fused image, the spatial details are extracted from the fine-resolution image at the base date, and are weighted by a proper injection gains. Then, the spatial details and the relative spectral information from the coarse-resolution images are blended to generate the fusion result. To further enhance its robustness to the noise, the local neighbourhood information, derived from the fine-resolution image and the fused result simultaneously, is introduced to refine the initial fused image to obtain a more accurate prediction result. The algorithm can effectively capture phenology change or land-cover-type change with minimum input data. Simulated data and two types of real satellite images with seasonal changes and land-cover-type changes are employed to test the performance of the proposed method. Compared with a spatial and temporal adaptive reflectance fusion model (STARFM) and a flexible spatio-temporal fusion algorithm (FSDAF), results show that the proposed approach improves the accuracy of fused images in phenology change area and effectively captures land-cover-type reflectance changes. 相似文献
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Journal of Computer Science and Technology - DOACROSS loops are significant parts in many important scientific and engineering applications, which are generally exploited pipeline/wave-front... 相似文献
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Xiaopo Wu Yangming Shi Weibo Meng Xiaofei Ma Nian Fang 《International Journal of Satellite Communications and Networking》2019,37(3):283-291
Electromagnetic signal emitted by satellite communication (satcom) transmitters are used to identify specific individual uplink satcom terminals sharing the common transponder in real environment, which is known as specific emitter identification (SEI) that allows for early indications and warning (I&W) of the targets carrying satcom furnishment and furthermore the real time electromagnetic situation awareness in military operations. In this paper, the authors are the first to propose the identification of specific transmitters of satcom by using probabilistic neural networks (PNN) to reach the goal of target recognition. We have been devoted to the examination by exploring the feasibility of utilizing the Hilbert transform to signal preprocessing, applying the discrete wavelet transform to feature extraction, and employing the PNN to perform the classification of stationary signals. There are a total of 1000 sampling time series with binary phase shift keying (BPSK) modulation originated by five types of satcom transmitters in the test. The established PNNs classifier implements the data testing and finally yields satisfactory accuracy at 8 dB(±1 dB) carrier to noise ratio, which indicates the feasibility of our method, and even the keen insight of its application in military. 相似文献