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The role of a depressor factor, atrial natriuretic peptide, in the development of arterial hypertension in adolescents with pubertal hypothalamic syndrome was studied in 52 patients and 13 healthy males aged 13-24 years. The duration of disease was 2-11 years. Radioimmunological methods were used to measure plasma atrial natriuretic peptide, plasma renin activity, and serum aldosterone. Patients with borderline arterial hypertension were found to have a significant reduction in their atrial natriuretic peptide levels, and this correlated directly with the renin-aldosterone system, demonstrating insufficiency of the depressor system in patients with pubertal hypothalamic syndrome and the involvement of atrial natriuretic peptide in the development of arterial hypertension, along with disturbances in the functional relationship between atrial natriuretic peptide and the renin-aldosterone system. 相似文献
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G. Dell'Agli O. Marino G. Mascolo P. Pernice A. Di Chiara G. Pepe U. Scotti Di Uccio 《Journal of Materials Science: Materials in Electronics》1990,1(1):20-24
The thermal stability of the superconducting phase of nominal composition YBa2Cu3O7–x
-sintered pellets has been studied with respect to different temperatures (ranging from 300 to 950° C), time (ranging from 1 to 72 h), oxygen partial pressure (from 4 Pa to 1 atm) and carbon dioxide partial pressure (from 10–4 Pa to 1 atm). Annealed samples were characterized by X-ray diffraction analysis, optical microscopy, and resistive measurements of the superconductive transition temperature. A stability field of the orthorhombic and tetragonal phases was obtained, showing a region of coexistance. The decomposition of the 1 2 3 phase is found to be strongly influenced by the presence of a small amount of CO2 (1 p.p.m.) in the sintering atmosphere. A sintering process is proposed to avoid the formation of by-products. 相似文献
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Laura Francesca Pisani Gian Eugenio Tontini Carmine Gentile Beatrice Marinoni Isabella Teani Nicoletta Nandi Pasquale Creo Emanuele Asti Luigi Bonavina Maurizio Vecchi Luca Pastorelli 《International journal of molecular sciences》2021,22(11)
Interleukin (IL)-33 is a member of the interleukin (IL)-1 family of cytokines linked to the development of inflammatory conditions and cancer in the gastrointestinal tract. This study is designed to investigate whether IL-33 has a direct effect on human gastric epithelial cells (GES-1), the human gastric adenocarcinoma cell line (AGS), and the gastric carcinoma cell line (NCI-N87) by assessing its role in the regulation of cell proliferation, migration, cell cycle, and apoptosis. Cell cycle regulation was also determined in ex vivo gastric cancer samples obtained during endoscopy and surgical procedures. Cell lines and tissue samples underwent stimulation with rhIL-33. Proliferation was assessed by XTT and CFSE assays, migration by wound healing assay, and apoptosis by caspase 3/7 activity assay and annexin V assay. Cell cycle was analyzed by means of propidium iodine assay, and gene expression regulation was assessed by RT-PCR profiling. We found that IL-33 has an antiproliferative and proapoptotic effect on cancer cell lines, and it can stimulate proliferation and reduce apoptosis in normal epithelial cell lines. These effects were also confirmed by the analysis of cell cycle gene expression, which showed a reduced expression of pro-proliferative genes in cancer cells, particularly in genes involved in G0/G1 and G2/M checkpoints. These results were confirmed by gene expression analysis on bioptic and surgical specimens. The aforementioned results indicate that IL-33 may be involved in cell proliferation in an environment- and cell-type-dependent manner. 相似文献
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The sintering behaviour of SiC-Si and SiC-Si-WC composites hot-pressed via silicon liquid phase has been studied. The results show that the increase of silicon makes the sintered materials densify at lower temperature and the grain growth is restricted due to the effect of the liquid. The strength of SiC-25 vol.% Si samples is higher than the strength obtained for SiC-5 vol.% Si with the same hot-pressing conditions. The addition of WC particles improves relative densities and strengths of SiC-Si ceramics. 相似文献
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Francesca Arcelli Fontana Mika V. Mäntylä Marco Zanoni Alessandro Marino 《Empirical Software Engineering》2016,21(3):1143-1191
Several code smell detection tools have been developed providing different results, because smells can be subjectively interpreted, and hence detected, in different ways. In this paper, we perform the largest experiment of applying machine learning algorithms to code smells to the best of our knowledge. We experiment 16 different machine-learning algorithms on four code smells (Data Class, Large Class, Feature Envy, Long Method) and 74 software systems, with 1986 manually validated code smell samples. We found that all algorithms achieved high performances in the cross-validation data set, yet the highest performances were obtained by J48 and Random Forest, while the worst performance were achieved by support vector machines. However, the lower prevalence of code smells, i.e., imbalanced data, in the entire data set caused varying performances that need to be addressed in the future studies. We conclude that the application of machine learning to the detection of these code smells can provide high accuracy (>96 %), and only a hundred training examples are needed to reach at least 95 % accuracy. 相似文献
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Mortensen Jesper Yu Insu Khanna Pankaj Tecchia Franco Spanlang Bernhard Marino Giuseppe Slater Mel 《Computer Graphics and Applications, IEEE》2008,28(6):56-64
Real-time global illumination in VR systems enhances scene realism by incorporating soft shadows, reflections of objects in the scene, and color bleeding. The Virtual Light Field (VLF) method enables real-time global illumination rendering in VR. The VLF has been integrated with the Extreme VR system for real-time GPU-based rendering in a Cave Automatic Virtual Environment. 相似文献
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Emanuele Viola 《Computational Complexity》2009,18(3):337-375
We prove new results on the circuit complexity of approximate majority, which is the problem of computing the majority of a given bit string whose fraction of 1’s is bounded away from 1/2 (by
a constant). We then apply these results to obtain new relationships between probabilistic time, BPTime (t), and alternating time, ∑O(1)Time (t). Our main results are the following:
相似文献
1. | We prove that depth-3 circuits with bottom fan-in (log n)/2 that compute approximate majority on n bits must have size at least 2n0.12^{n^{0.1}}. As a corollary we obtain that there is no black-box proof that BPTime (t) í ?2\subseteq \sum_2Time (o(t2)). This complements the (black-box) result that BPTime (t) í ?2\subseteq \sum_2Time (t2 · poly log t) (Sipser and Gács, STOC ’83; Lautemann, IPL ’83). |
2. | We prove that approximate majority is computable by uniform polynomial-size circuits of depth 3. Prior to our work, the only known polynomial-size depth-3 circuits for approximate majority were non-uniform (Ajtai, Ann. Pure Appl. Logic ’83). We also prove that BPTime (t) í ?3\subseteq \sum_3Time (t · poly log t). This complements our results in (1). |
3. | We prove new lower bounds for solving QSAT3 ? ?3\in \sum_3Time (n · poly log n) on probabilistic computational models. In particular, we prove that solving QSAT3 requires time n1+Ω(1) on Turing machines with a random-access input tape and a sequential-access work tape that is initialized with random bits. No nontrivial lower bound was previously known on this model (for a function computable in linear space). |