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1.
G Chessa Ricotti R Cutrì A De Bernardi M Funis S Frediani 《Canadian Metallurgical Quarterly》1995,17(3):271-273
The authors describe 5 cases, 3 boys and 2 girls, with idiopathic growth hormone deficiency in prepubertal age, treated with human growth hormone. In four of five cases the response to treatment with GH was relevant. Only in one case (F1) the response was negative. The results of this study confirm that rhGH is a safe and effective therapy in children with GHD. 相似文献
2.
M Martelli R Rapezzi L Roncone E Davì L Mancini 《Canadian Metallurgical Quarterly》1996,48(6):235-238
The authors examine 162 cervico-vaginal smears of women in peri-menopause presenting cellular alterations (ASCUS). These patients were treated with a local topic therapy as the persistence of these alterations in 23 cases (14.2%) second level analyses were performed: gynecological visit, colposcopy and biopsy. In addition to inflammatory aspects 2 in situ carcinomas and 2 moderate dysplasias were recorded. We believe therefore that cytology could be a valid aid also in pre-menopausal women in the cervico-vaginal pathology. 相似文献
3.
A. Calcagnì L. Lombardi E. Pascali 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2014,18(8):1575-1588
LR-fuzzy numbers are widely used in Fuzzy Set Theory applications based on the standard definition of convex fuzzy sets. However, in some empirical contexts such as, for example, human decision making and ratings, convex representations might not be capable to capture more complex structures in the data. Moreover, non-convexity seems to arise as a natural property in many applications based on fuzzy systems (e.g., fuzzy scales of measurement). In these contexts, the usage of standard fuzzy statistical techniques could be questionable. A possible way out consists in adopting ad-hoc data manipulation procedures to transform non-convex data into standard convex representations. However, these procedures can artificially mask relevant information carried out by the non-convexity property. To overcome this problem, in this article we introduce a novel computational definition of non-convex fuzzy number which extends the traditional definition of LR-fuzzy number. Moreover, we also present a new fuzzy regression model for crisp input/non-convex fuzzy output data based on the fuzzy least squares approach. In order to better highlight some important characteristics of the model, we applied the fuzzy regression model to some datasets characterized by convex as well as non-convex features. Finally, some critical points are outlined in the final section of the article together with suggestions about future extensions of this work. 相似文献
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6.
Unraveling Unprecedented Charge Carrier Mobility through Structure Property Relationship of Four Isomers of Didodecyl[1]benzothieno[3,2‐b][1]benzothiophene
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Yusuke Tsutsui Guillaume Schweicher Basab Chattopadhyay Tsuneaki Sakurai Jean‐Baptiste Arlin Christian Ruzié Almaz Aliev Artur Ciesielski Alan R. Kennedy Vincent Lemaur Yoann Olivier Rachid Hadji Lionel Sanguinet Frédéric Castet Silvio Osella Dmytro Dudenko David Beljonne Jérôme Cornil Paolo Samorì Shu Seki Yves H. Geerts 《Advanced materials (Deerfield Beach, Fla.)》2016,28(33):7106-7114
7.
DA Kokodoko C Pasquino AM Barra L Santoro MG Crespi M Bertoni G Giorgetti L Ballardini C Cargnelutti L Spinazzola M Gallì 《Canadian Metallurgical Quarterly》1996,18(4-6):129-134
With the intent of estimating the proprioceptive sensitivity of the cervical rachis, the Authors subjected 17 healthy volunteers and 20 patients suffering from various cervical disorders to a clinical head positioning test, which was previously experimented upon by several french Authors was modified under certain aspects by our equipe. The test, consists in flexion and extension of the head after maximal rotations to the left and right, then repositioning the head at the starting point "0" which corresponds to the crossing point of two orthogonal axis of a target. The positions are marked on the target by a laser beam situated on the helmet worn by the subject undergoing testing. The results obtained corresponding to the errors committed regarding point "0", permit us to confirm the reliability of the test and significant definitions between the control group and the patients suffering from cervical disorders. 相似文献
8.
A. Borzì 《Computing and Visualization in Science》2010,13(4):153-160
A multigrid and sparse-grid computational approach to solving nonlinear elliptic optimal control problems with random coefficients
is presented. The proposed scheme combines multigrid methods with sparse-grids collocation techniques. Within this framework
the influence of randomness of problem’s coefficients on the control provided by the optimal control theory is investigated.
Numerical results of computation of stochastic optimal control solutions and formulation of mean control functions are presented. 相似文献
9.
Jean Mayrand Jean-François Patenaude Ettore Merlo Michel Dagenais Bruno Laguë 《Annals of Software Engineering》2000,9(1-2):117-141
This paper presents an assessment method to evaluate the quality of object oriented software systems. The assessment method is based on source code abstraction, object–oriented metrics and graphical representation. The metrics used and the underlying model representing the software are presented. The assessment method experiment is part of an industrial research effort with the Bell Canada Quality Engineering and Research Group. It helps evaluators assess the quality and risks associated with software by identifying code fragments presenting unusual characteristics. The assessment method evaluates object–oriented software systems at three levels of granularity: system level, class level and method level. One large C++ and eight Java software systems, for a total of over one million lines of code, are presented as case studies. A critical analysis of the results is presented comparing the systems and the two languages. 相似文献
10.
Teodolinda Di Risi Mariella Cuomo Roberta Vinciguerra Sara Ferraro Rosa Della Monica Davide Costabile Michela Buonaiuto Federica Trio Ettore Capoluongo Roberta Visconti Eleonora Riccio Antonio Pisani Lorenzo Chiariotti 《International journal of molecular sciences》2022,23(20)
Anderson–Fabry disease (FD) is an X-linked disease caused by a functional deficit of the α-galactosidase A enzyme. FD diagnosis relies on the clinical manifestations and research of GLA gene mutations. However, because of the lack of a clear genotype/phenotype correlation, FD diagnosis can be challenging. Recently, several studies have highlighted the importance of investigating DNA methylation patterns for confirming the correct diagnosis of different rare Mendelian diseases, but to date, no such studies have been reported for FD. Thus, in the present investigation, we analyzed for the first time the genome-wide methylation profile of a well-characterized cohort of patients with Fabry disease. We profiled the methylation status of about 850,000 CpG sites in 5 FD patients, all carrying the same mutation in the GLA gene (exon 6 c.901C>G) and presenting comparable low levels of α-Gal A activity. We found that, although the whole methylome profile did not discriminate the FD group from the unaffected one, several genes were significantly differentially methylated in Fabry patients. Thus, we provide here a proof of concept, to be tested in patients with different mutations and in a larger cohort, that the methylation state of specific genes can potentially identify Fabry patients and possibly predict organ involvement and disease evolution. 相似文献