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A model is developed for damage produced by the growth of isolated grain boundary cavities under power law creep. This damage model is combined with the small scale yielding stress and strain fields to predict the damage ahead of a stationary and a steadily propagating crack tip in an elastic-power law creeping material. A failure criterion, based upon the damage ahead of the crack tip attaining a critical value, is invoked. This criterion leads to predictions for the incubation time prior to initiation of crack growth and for the relationship between the remote stress intensity factor and the steady state crack speed. Results are presented for both elastic-primary and -secondary creep crack growth. In either case, there exists a minimum stress intensity factor below which steady state crack growth is not possible. Comparisons of the predictions of this model with others for steady state crack propagation in elastic-secondary creeping materials are also made.
Résumé On développe un modèle décrivant le dommage produit par la croissance de cavités isolées aux frontières des grains sous l'effet d'un fluage selon une loi parabolique. Ce modèle d'endommagement est combiné aux champs de contrainte et de déformation conduisant à une plastification à petite échelle, en vue de prédire le dommage qui se produit en avant de l'extrémité d'une fissure stationaire et en propagation lente, dans un matériau soumis à fluage selon une loi élastique. On invoque un critère de rupture basé sur la valeur critique atteinte par le dommage en avant de l'extrémité de la fisure. Ce critère conduit à prédire le temps d'incubation avant amorçage de la croissance d'une fissure, ainsi que la relation entre le facteur d'intensité des contraintes appliquées à une certaine distance et la vitesse de croissance stable de la fissure.On présente les résultats dans les cas de croissance d'une fissure de fluage au stade secondaire. Dans les deux cas, il existe un facteur d'intensité de contrainte minimum en dessous duquel une croissance stable de la fissure n'est pas possible. On procède également à des comparaisons des prédictions données par ce modèle avec d'autres, pour la propagation en état stable d'une fissure dans des matériaux soumis à fluage secondaire élastique.
  相似文献   
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Structural elements combining Ultra-High Performance Fiber Reinforced Concretes (UHPFRC) and concrete offer a high potential in view of rehabilitation and modification of existing structures. The investigation of the time-dependent behavior of composite “UHPFRC-concrete” elements is a fundamental step in the determination of durability and serviceability. For this, an experimental program was conducted on large composite “UHPFRC-concrete” beams and a numerical model was validated with the test results. The experimental results and a parametric study performed with the numerical model showed that UHPFRC and normal strength reinforced concrete are compatible in the long-term and that the critical period of composite “UHPFRC-concrete” elements are the first 90 days after the casting of the UHPFRC layer. Thus, the high potential of such composite elements can be exploited also in the long term.  相似文献   
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Adaptive histogram equalization (AHE) and intensity windowing have been compared using psychophysical observer studies. Experienced radiologists were shown clinical CT (computerized tomographic) images of the chest. Into some of the images, appropriate artificial lesions were introduced; the physicians were then shown the images processed with both AHE and intensity windowing. They were asked to assess the probability that a given image contained the artificial lesion, and their accuracy was measured. The results of these experiments show that for this particular diagnostic task, there was no significant difference in the ability of the two methods to depict luminance contrast; thus, further evaluation of AHE using controlled clinical trials is indicated.  相似文献   
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We present an algorithm for combining the elements of subsequences of a sequence with an associative operator. The subsequences are given by a sliding window of varying size. Our algorithm is greedy and computes the result with the minimal number of operator applications.  相似文献   
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Proteomics analysis of serum from patients with type 1 diabetes (T1D) may lead to novel biomarkers for prediction of disease and for patient monitoring. However, the serum proteome is highly sensitive to sample processing and before proteomics biomarker research serum cohorts should preferably be examined for potential bias between sample groups. SELDI‐TOF MS protein profiling was used for preliminary evaluation of a biological‐bank with 766 serum samples from 270 patients with T1D, collected at 18 different paediatric centers representing 15 countries in Europe and Japan over 2 years (2000–2002). Samples collected 1 (n = 270), 6 (n = 248), and 12 (n = 248) months after T1D diagnosis were grouped across centers and compared. The serum protein profiles varied with collection site and day of analysis; however, markers of sample processing were not systematically different between samples collected at different times after diagnosis. Three members of the apolipoprotein family increased with time in patient serum collected 1, 6, and 12 months after diagnosis (ANOVA, p<0.001). These results support the use of this serum cohort for further proteomic studies and illustrate the potential of high‐throughput MALDI/SELDI‐TOF MS protein profiling for evaluation of serum cohorts before proteomics biomarker research.  相似文献   
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A composed morphology of iron oxide microstructures covered with very thin nanowires (NWs) with diameter of 15–50 nm has been presented. By oxidizing metallic Fe microparticles at 255 °C for 12 and 24 h, dense iron oxide NW networks bridging prepatterned Au/Cr pads are obtained. X‐ray photoelectron spectroscopy studies reveal formation of α‐Fe2O3 and Fe3O4 on the surface and it is confirmed by detailed high‐resolution transmission electron microscopy and selected area electron diffraction (SAED) investigations that NWs are single phase α‐Fe2O3 and some domains of single phase Fe3O4. Localized synthesis of such nano‐ and microparticles directly on sensor platform/structure at 255 °C for 24 h and reoxidation at 650 °C for 0.2–2 h, yield in highly performance and reliable detection of acetone vapor with fast response and recovery times. First nanosensors on a single α‐Fe2O3 nanowire are fabricated and studied showing excellent performances and an increase in acetone response by decrease of their diameter was developed. The facile technological approach enables this nanomaterial as candidate for a range of applications in the field of nanoelectronics such as nanosensors and biomedicine devices, especially for breath analysis in the treatment of diabetes patients.  相似文献   
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