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Patricia Seoane-Collazo Amparo Romero-Pic Eva Rial-Pensado Laura Liares-Pose nxela Estvez-Salguero Johan Fern Rubn Nogueiras Carlos Diguez Miguel Lpez 《International journal of molecular sciences》2021,22(4)
Several studies have reported that nicotine, the main bioactive component of tobacco, exerts a marked negative energy balance. Apart from its anorectic action, nicotine also modulates energy expenditure, by regulating brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. These effects are mainly controlled at the central level by modulation of hypothalamic neuropeptide systems and energy sensors, such as AMP-activated protein kinase (AMPK). In this study, we aimed to investigate the kappa opioid receptor (κOR)/dynorphin signaling in the modulation of nicotine’s effects on energy balance. We found that body weight loss after nicotine treatment is associated with a down-regulation of the κOR endogenous ligand dynorphin precursor and with a marked reduction in κOR signaling and the p70 S6 kinase/ribosomal protein S6 (S6K/rpS6) pathway in the lateral hypothalamic area (LHA). The inhibition of these pathways by nicotine was completely blunted in κOR deficient mice, after central pharmacological blockade of κOR, and in rodents where κOR was genetically knocked down specifically in the LHA. Moreover, κOR-mediated nicotine effects on body weight do not depend on orexin. These data unravel a new central regulatory pathway modulating nicotine’s effects on energy balance. 相似文献
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Celia Nieto Milena A. Vega Eva M. Martín del Valle 《International journal of molecular sciences》2021,22(6)
Ferroptosis is gaining followers as mechanism of selective killing cancer cells in a non-apoptotic manner, and novel nanosystems capable of inducing this iron-dependent death are being increasingly developed. Among them, polydopamine nanoparticles (PDA NPs) are arousing interest, since they have great capability of chelating iron. In this work, PDA NPs were loaded with Fe3+ at different pH values to assess the importance that the pH may have in determining their therapeutic activity and selectivity. In addition, doxorubicin was also loaded to the nanoparticles to achieve a synergist effect. The in vitro assays that were performed with the BT474 and HS5 cell lines showed that, when Fe3+ was adsorbed in PDA NPs at pH values close to which Fe(OH)3 begins to be formed, these nanoparticles had greater antitumor activity and selectivity despite having chelated a smaller amount of Fe3+. Otherwise, it was demonstrated that Fe3+ could be released in the late endo/lysosomes thanks to their acidic pH and their Ca2+ content, and that when Fe3+ was co-transported with doxorubicin, the therapeutic activity of PDA NPs was enhanced. Thus, reported PDA NPs loaded with both Fe3+ and doxorubicin may constitute a good approach to target breast tumors. 相似文献
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Evangelopoulos Xenophon Brockmeier Austin J. Mu Tingting Goulermas John Y. 《Machine Learning》2019,108(4):595-626
Machine Learning - We propose a set of highly scalable algorithms for the combinatorial data analysis problem of seriating similarity matrices. Seriation consists of finding a permutation of data... 相似文献
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A batch reactor may be combined directly with a distillation column by distilling off the light component product in order to increase the reactor temperature or to improve the product yield of an equilibrium reaction. The same amount of the light product should be removed as the amount being formed by the reaction at any time. A linearized model has been developed which describes the process behaviour satisfactorily for control analysis purposes. The controllability of a combined batch reactor/batch distillation column is found to depend strongly on the operating conditions and on the time during the run. In general, controlling only the reactor temperature (one-point bottom control) is difficult since the set-point has to be specified below a maximum value in order to avoid break-through of an intermediate component in the ditillate. This maximum value may be difficult to know a priori. For the example considered in this study, control of both reactor temperature and distillate composition (two-point control) is also found to be difficult due to large interactions in the column. As with one-point bottom control, the reactor temperature has to be specified below a maximum value. However, energy can be saved since the heat duty can be decreased with time. Controlling the temperature on a tray in the column (one-point column control) is found to give good performance for the given process with no loss of reactant and a high reactor temperature, although no direct control of the reactor temperature is obtained. 相似文献
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Nicholas Biery Marc De Graef Jack Beuth Rafel Raban Andrew Elliott Tresa M. Pollock Curt Austin 《Metallurgical and Materials Transactions A》2002,33(10):3127-3136
Tensile experiments have been performed on specimens of four different investment-cast TiAl-based alloys with variations in
casting conditions. The average ductilities obtained in these experiments vary between approximately 0.8 to 2.0 pct plastic
strain to failure in tension. By using the three-parameter form of the Weibull relation, with the 0.2 pct offset yield strength
as the minimum failure strength, the resulting variability in the data can be quantified and is found to be similar for those
alloys with similar microstructural scale (grain size). Large variations in lamellar volume fraction, segregation, and phase
distribution have a minor influence on property variability, compared to changes in the scale of the grain structure caused
by either variations in cooling rate during casting or the addition of grain refiners. 相似文献
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Jen-Chwen Lin T. Leo Ngai Y. Austin Chang 《Metallurgical and Materials Transactions A》1986,17(7):1241-1245
Defect equilibria for binary semiconducting compound phases which exhibit ionized native donor and acceptor defects were considered,
and equations describing the pressure-temperature-composition relationships for these compound phases were derived. These
equations were used to analyze experimental data from the literature for tin telluride. Excellent agreement was obtained between
calculated thermodynamic and phase boundary values and experimental data. The approach presented is readily extended to obtain
equations for the thermodynamic properties of ternary and higher order semiconducting compound phases. 相似文献
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