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排序方式: 共有279条查询结果,搜索用时 15 毫秒
1.
F Nunes J Saraiva A Francisca MJ Botica Mdo C Diniz I Cabral 《Canadian Metallurgical Quarterly》1997,18(6):488-491
OBJECTIVE: The purpose of this study was to characterise the occurrence of multiple primitive gynaecological malignant neoplasias, restricted to the genital tract and breast or associated with other organs, and to detect which types of association are most frequent concerning location, histology and staging. POPULATION AND METHODS: The records of patients with gynaecological cancer at the Portuguese Institute of Oncology--Lisbon Centre, between 1986 and 1993 were used in this study. RESULTS: Of the 10,746 women with gynaecological cancer, 91 (0.8%) were found to have a second primitive malignant neoplasia. Of these neoplasias, 64% (58 cases) were also located at a gynaecological site. The most frequent associations were endometrium/breast (13 cases), bilateral breast (12 cases) and ovary/endometrium (11 cases). The majority of primitive multiple gynaecological tumours were synchronous. Regarding gynaecological cancer and non-gynaecological cancer, in 28 cases (31%), the most common non-gynaecological location was the colon/rectum. Five patients had triple tumours. CONCLUSION: Although these situations are relatively rare the possibility of multiple primitive cancers should be considered with the presence of malignant tumours in two or more organs. This distinction between multiple primitive or metastatic cancers could be important for treatment as well as prognosis. 相似文献
2.
Julia Peas-Martínez María N. Barrachina Ernesto Jos Cuenca-Zamora Gins Luengo-Gil Susana Beln Bravo Eva Caparrs-Prez Raúl Teruel-Montoya Jos Eliseo-Blanco Vicente Vicente ngel García Irene Martínez-Martínez Francisca Ferrer-Marín 《International journal of molecular sciences》2021,22(4)
Exosomes are extracellular vesicles that contain nucleic acids, lipids and metabolites, and play a critical role in health and disease as mediators of intercellular communication. The majority of extracellular vesicles in the blood are platelet-derived. Compared to adults, neonatal platelets are hyporeactive and show impaired granule release, associated with defects in Soluble N-ethylmaleimide-sensitive fusion Attachment protein REceptor (SNARE) proteins. Since these proteins participate in biogenesis of exosomes, we investigated the potential differences between newborn and adult plasma-derived exosomes. Plasma-derived exosomes were isolated by ultracentrifugation of umbilical cord blood from full-term neonates or peripheral blood from adults. Exosome characterization included size determination by transmission electron microscopy and quantitative proteomic analysis. Plasma-derived exosomes from neonates were significantly smaller and contained 65% less protein than those from adults. Remarkably, 131 proteins were found to be differentially expressed, 83 overexpressed and 48 underexpressed in neonatal (vs. adult) exosomes. Whereas the upregulated proteins in plasma exosomes from neonates are associated with platelet activation, coagulation and granule secretion, most of the underexpressed proteins are immunoglobulins. This is the first study showing that exosome size and content change with age. Our findings may contribute to elucidating the potential “developmental hemostatic mismatch risk” associated with transfusions containing plasma exosomes from adults. 相似文献
3.
Neural Network and Classification Approach in Identifying Customer Behavior in the Banking Sector: A Case Study of an International Bank
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Francisca Nonyelum Ogwueleka Sanjay Misra Ricardo Colomo‐Palacios Luis Fernandez 《人机工程学与制造业中的人性因素》2015,25(1):28-42
The customer relationship focus for banks is in development of main competencies and strategies of building strong profitable customer relationships through considering and managing the customer impression, influence on the culture of the bank, satisfactory treatment, and assessment of valued relationship building. Artificial neural networks (ANNs) are used after data segmentation and classification, where the designed model register records into two class sets, that is, the training and testing sets. ANN predicts new customer behavior from previously observed customer behavior after executing the process of learning from existing data. This article proposes an ANN model, which is developed using a six‐step procedure. The back‐propagation algorithm is used to train the ANN by adjusting its weights to minimize the difference between the current ANN output and the desired output. An evaluation process is conducted to determine whether the ANN has learned how to perform. The training process is halted periodically, and its performance is tested until an acceptable result is obtained. The principles underlying detection software are grounded in classical statistical decision theory. 相似文献
4.
Raphael M. Jungers Francisca Zamorano Vincent D. Blondel Alain Vande Wouwer Georges BastinAuthor vitae 《Automatica》2011,47(6):1255-1259
The concept of elementary flux vector is valuable in a number of applications of metabolic engineering. For instance, in metabolic flux analysis, each admissible flux vector can be expressed as a non-negative linear combination of a small number of elementary flux vectors. However a critical issue concerns the total number of elementary flux vectors which may be huge because it combinatorially increases with the size of the metabolic network. In this paper we present a fast algorithm that randomly computes a decomposition of admissible flux vectors in a minimal number of elementary flux vectors without explicitly enumerating all of them. 相似文献
5.
Alejandro Echeverría Matías Améstica Francisca Gil Miguel Nussbaum Enrique Barrios Sandra Leclerc 《Computers in human behavior》2012
Computer Supported Collaborative Learning is a pedagogical approach that can be used for deploying educational games in the classroom. However, there is no clear understanding as to which technological platforms are better suited for deploying co-located collaborative games, nor the general affordances that are required. In this work we explore two different technological platforms for developing collaborative games in the classroom: one based on augmented reality technology and the other based on multiple-mice technology. In both cases, the same game was introduced to teach electrostatics and the results were compared experimentally using a real class. 相似文献
6.
Andrea Bagn Jos A. Morales-García Christian Grin-Ferr Caridad Díaz Jos Prez del Palacio Maria C. Ramos Francisca Vicente Beln Prez Jos Brea María Isabel Loza Merc Palls Carmen Escolano 《International journal of molecular sciences》2022,23(10)
The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind due to their vast prevalence and the lack of efficacious treatments. In this scenario, we focused on imidazoline I2 receptors (I2-IR) that are widely distributed in the brain and are altered in patients with brain disorders. We took the challenge of modulating I2-IR by developing structurally new molecules, in particular, a family of bicyclic α-iminophosphonates, endowed with high affinity and selectivity to these receptors. Treatment of two murine models, one for age-related cognitive decline and the other for Alzheimer’s disease (AD), with representative compound B06 ameliorated their cognitive impairment and improved their behavioural condition. Furthermore, B06 revealed beneficial in vitro ADME-Tox properties. The pharmacokinetics (PK) and metabolic profile are reported to de-risk B06 for progressing in the preclinical development. To further characterize the pharmacological properties of B06, we assessed its neuroprotective properties and beneficial effect in an in vitro model of Parkinson’s disease (PD). B06 rescued the human dopaminergic cell line SH-SY5Y from death after treatment with 6-hydroxydopamine (6-OHDA) and showed a crucial anti-inflammatory effect in a cellular model of neuroinflammation. This research reveals B06 as a putative candidate for advancing in the difficult path of drug discovery and supports the modulation of I2-IR as a fresh approach for the therapy of ND. 相似文献
7.
Matilde Ortiz-Gonzalez Ignacio Prez-Victoria Inmaculada Ramirez-Macias Nuria de Pedro Angel Linde-Rodriguez Víctor Gonzlez-Menndez Victoria Sanchez-Martin Jesús Martín Ana Soriano-Lerma Olga Genilloud Virginia Perez-Carrasco Francisca Vicente Jos Maceira Carlos A. Rodrígues-Poveda Jos María Navarro-Marí Fernando Reyes Miguel Soriano Jose A. Garcia-Salcedo 《International journal of molecular sciences》2022,23(11)
8.
Francisca Rodrigues Carlos Gaspar Ana Palmeira-de-Oliveira Bruno Sarmento M. Helena Amaral M. Beatriz P. P. Oliveira 《Drug development and industrial pharmacy》2016,42(1):99-106
Context: Currently, there is an increasing interest of cosmetic industry on natural extracts. The inclusion of antioxidants in topical formulations can contribute to minimize oxidative stress in the skin, which has been associated with aging. Also, questions of sustainability are leading to the study of new cosmetic ingredients obtained from food by-products. Coffee Silverskin (CS) is a food by-product with established antioxidant activity that has not yet been incorporated into a topical formulation.Objective: The aim of this study was to evaluate the physical and microbiological stabilities and antioxidant activity of a hand cream formulation containing 2.5% (w/w) of CS extract upon production and after 6 months of shelf-life and in vitro safety/cytotoxicity on skin cell lines after production.Materials and methods: The in vitro cytotoxicity was evaluated with MTS and LDH assays, at different concentrations, in HaCaT and HFF-1 cells. Formulations were stored at 25?°C/65% RH and 40?°C/75% RH. Physical, microbiological, and antioxidant stabilities were evaluated by centrifugation, viscosity, total colony count, DPPH and total phenolic content (TPC).Results: The hand cream containing 2.5% (w/w) of CS extract showed stable physical characteristics independently of the storage conditions. The DPPH activity and TPC of the CS formulation were significantly higher compared with those of the base formulation. However, during storage, the antioxidant activity decreases slightly. Microbiological quality was also confirmed. No cytotoxic effects were observed.Conclusion: It is possible to suggest that this formulation is stable under extreme conditions and safe for topical use. 相似文献
9.
10.
Francisca Holgado Gloria Márquez-Ruiz María Victoria Ruiz-Méndez Joaquín Velasco 《International Journal of Food Science & Technology》2019,54(8):2520-2528
The influence of the drying method, freeze-drying and spray-drying, on the oxidative stability of microencapsulated sunflower oil depended on the type of encapsulation matrix. For a dairy-type matrix, formed by sodium caseinate and lactose, greater losses of tocopherols were detected during spray-drying, but both the free and encapsulated oil fractions were more stable against lipid oxidation than their freeze-dried counterparts. Results suggested that the free oil was also constituted by droplets that preserved their interfacial membrane and were protected by the matrix. Therefore, the free oil was not necessarily the non-encapsulated fraction. For a matrix constituted by gelatine, maltodextrin and sucrose, the emulsion showed low stability and a great destabilisation during spray-drying. No significant effect of the drying method on the oxidative stability of the encapsulated fraction was found with this matrix, but the free oil of the spray-dried sample oxidised faster, probably due to the emulsion destabilisation observed, which gave rise to a great amount of oil on the particle surface as a consequence of large droplets poorly stabilised. 相似文献