加强水能管理推进有序开发

在新的历史时期,农村水电作为清洁可再生能源面临着前所未有的发展机遇,特别是《可再生能源法》的出台给水能资源开发利用和农村水电发展提供了法律保障。此时,我们探讨如何加强水能管理,具有十分深远的意义。     

A pH-responsive polymersome depleting regulatory T cells and blocking A2A receptor for cancer immunotherapy

The immunosuppressive tumor microenvironment(ITM)and low immunogenicity of tumors greatly limit cancer immunotherapy efficacy.The approach of solely depleting r...     

像汉水那样奔腾不息——记陕西省电力公司A级工程技术专家瞿富强

朋友,你到过安康水电站吗?你见过那巍峨壮观的大坝和碧波荡漾的百里湖面吗?你见过那湖水像奔腾的万马从闸门急速蜂拥的宏伟场面吗?你听到过那湖水似威武的千军发出震天动地的吼声吗?……     

A Size-Changeable Collagenase-Modified Nanoscavenger for Increasing Penetration and Retention of Nanomedicine in Deep Tumor Tissue

The complex tumor microenvironment constitutes a variety of barriers to prevent nanoparticles (NPs) delivery and results in extremely low accumulation of nanomedicines in solid tumors. Here, a newly developed size-changeable collagenase-modified polymer micelle is employed to enhance the penetration and retention of nanomedicine in deep tumor tissue. The TCPPB micelle is first formed by self-assembly of maleimide-terminated poly(ethylene glycol)-block-poly(β-amino ester) (MAL-PEG-PBAE) and succinic anhydride-modified cisplatin-conjugated poly(ε-caprolactone)-block-poly(ethylene oxide)-triphenylphosphonium (CDDP-PCL-PEO-TPP). Next, Col-TCPPB NPs are prepared through a “click” chemical combination of thiolated collagenase and maleimide groups on TCPPB micelle. Finally, biocompatible chondroitin sulfate (CS) is coated to obtain CS/Col-TCPPB NPs for avoiding collagenase inactivation in blood circulation. In tumor acidic microenvironment, the hydrophobic PBAE segments of the resultant micelles become hydrophilic, leading to a dissociation and subsequent dissolution of partial collagenase-containing components (Col-PEG-PBAE) from NPs. The dissolved Col-PEG-PBAE promotes the digestion of collagen fibers in tumor tissue like a scavenger, which enhances the NPs penetration. Simultaneously, the increased hydrophilicity of residual Col-PEG-PBAE in the micellar matrix causes an expansion of the NPs, resulting in an enhanced intratumoral retention. In tumor cells, the NPs target to release the cisplatin drugs into mitochondria, achieving an excellent anticancer efficacy.     

基于自适应模糊PID控制的SBR污水处理系统

采用自适应模糊PID控制方法控制污水处理中的溶解氧,并设计基于自适应模糊PID的控制系统。仿真结果和实际应用表明,采用自适应模糊PID控制器后,控制系统的响应速度加快,超调量减小,过渡时间大大缩短,振荡次数减少,具有较强的鲁棒性和良好的稳定性。     

加强水能资源管理促进农村水电建设

本文介绍了重庆市的水能资源开发和管理现状,就如何进一步加强水能资源开发和管理工作提出了建议。     

加强水能管理推进有序开发

一、认真学习贯彻<可再生能源法>,充分认识水能的战略作用和地位 水能是水资源不可分割的重要组成部分,是清洁可再生的绿色能源,具有独特的自然属性、社会属性和经济属性.水力发电是利用河流的势能,通过物理过程转换产生电能,经过人的劳动实现了使用价值向价值的过渡和转变.电能以其优良的特性,成为直接服务于社会、经济和大众的优质能源,是人、自然、社会和谐发展的具体体现.水力发电不污染环境,并且发电效率高,水电站的水库还具有防洪、灌溉、城乡供水和工业用水、养殖、旅游等多种功能,经济效益与社会效益都很高.尤其是小水电技术相对成熟,具有分散开发、就地成网、就地供电、供电成本低的特点,使得小水电成为可持续利用支持经济社会发展的朝阳产业,特别是在西部地区,很多地方把开发水能资源作为拉动区域经济社会发展的首选产业之一.     

采用 sEMG 的手势识别用 APSO/ CS-SVM 方法

针对基于参数寻优的支持向量机(SVM)方法存在早熟收敛、全局寻优能力差、局部寻优精度低等问题,提出一种自适应粒子群/布谷鸟(APSO/CS)参数寻优方法,旨在实现SVM模型中核函数参数、惩罚因子的优化。测试函数分别对APSO/CS、APSO、CS的参数寻优性能进行了对比分析,表明APSO/CS寻优能够加快局部和全局寻优的收敛速度。采用表面肌电信号(sEMG)对APSO/CS、APSO、CS寻优的SVM方法进行了手势识别对比测试,实验测试结果表明,采用APSO/CS寻优的SVM方法进行手势识别时正确率最高,最高正确率可达94.50%,该方法可为识别分类算法提供一种新思路。     

Stimuli-responsive nitric oxide generator for light-triggered synergistic cancer photothermal/gas therapy

As a minimally invasive local cancer therapy, photothermal therapy (PTT) has aroused intensive interests in recent years. However, the therapeutic effect of PTT is still unsatisfying due to the production of heat shock proteins. Combination therapy has been regarded as a promising strategy to enhance therapeutic efficiency. In this study, a novel intelligent protoporphyrin (PpIX)-based polymer nanoplatform is developed for synergistic enhancement of cancer treatment through combined PTT and nitric oxide (NO) therapy. The core of the nanoparticle is composed of closely packed porphyrin-based NO donors and PpIX branches of the block copolymer. The prepared nanoparticles exhibit good photothermal conversion capability and high sensitivity to release NO under light illumination. And the produced high localized temperature and intracellular NO concentration could efficiently inhibit cancer cells both in vitro and in vivo. More important, this therapeutic nanoplatform can fundamentally eliminate the emergence of multidrug resistance and overcome the hypoxia microenvironment in tumors because of the absence of chemotherapeutic drugs and the oxygen-independent process, thus opening up new ideas for multifunctional therapeutic agent design for treatment of multidrug-resistant cancer.