Model-driven engineering for mobile robotic systems: a systematic mapping study

Software and Systems Modeling - Mobile robots operate in various environments (e.g. aquatic, aerial, or terrestrial), they come in many diverse shapes and they are increasingly becoming parts of...     

2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B

A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (K_i) values in the sub-micromolar range and a good selectivity index (K_{i MAO-A}/K_{i MAO-B}>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a ) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity.     

智能型激光控制器提高灵活性并节省空间

激光二极管是宽带调幅光纤发射系统的核心器件。光纤系统依赖于激光的稳定性,但未受调节控制的激光二极管特性却常因制造误差、温度和使用日久所造成的参数改变而变得不稳定。因此,光纤通信系统需要专用电路来控制重要的激光二极管参数,以确保它们稳定操作。虽然激光控制电路都     

Plasma mevalonate concentrations in uremic patients

Mevalonic acid (mevalonate or MVA), is an obligate precursor in the biosynthetic pathway of cholesterol. It is partially metabolized by the kidneys and its plasma concentrations are an index of endogenous cholesterol synthesis. The aim of the present study was to evaluate plasma MVA concentrations in uremic patients with different degrees of chronic renal failure (CRF; group A), and the effects of a single hemodialysis treatment on plasma MVA in a group of patients with end-stage renal disease (ESRD; group B). CRF patients exhibited a higher mean basal mevalonate concentration (13.3 +/- 6.5 ng/ml) than control subjects (4.68 +/- 1.32 ng/ml; P < 0.001). A statistically significant direct correlation was evident in CRF patients between mevalonate and creatinine plasma levels (r = 0.86; P < 0.001). A single hemodialysis treatment was associated with a significant reduction of plasma mevalonate concentrations four hours after the hemodialysis session (-57%; P < 0.001) and an increase up to the basal values 24 hours after the end of the treatment. In conclusion, our results demonstrated: (i) higher plasma MVA concentrations in patients with decreased renal function; (ii) a direct relationship between plasma MVA levels and the degree of kidney failure as expressed by creatinine plasma concentrations; and (iii) a clear cut reduction of elevated plasma MVA levels after a single hemodialysis treatment.     

On the cramer-rao bound for carrier frequency estimation in the presence of phase noise

We consider the carrier frequency offset estimation in a digital burst-mode satellite transmission affected by phase noise. The corresponding Cramer-Rao lower bound is analyzed for linear modulations under a Wiener phase noise model and in the hypothesis of knowledge of the transmitted data. Even if we resort to a Monte Carlo average, from a computational point of view the evaluation of the Cramer-Rao bound is very hard. We introduce a simple but very accurate approximation that allows to carry out this task in a very easy way. As it will be shown, the presence of the phase noise produces a remarkable performance degradation of. the frequency estimation accuracy. In addition, we provide asymptotic expressions of the Cramer-Rao bound, from which the effect of the phase noise and the dependence on the system parameters of the frequency offset estimation accuracy clearly result. Finally, as a by-product of our derivations and approximations, we derive a couple of estimators specifically tailored for the phase noise channel that will be compared with the classical Rife and Boorstyn algorithm, gaining in this way some important hints on the estimators to be used in this scenario     

The intervalley X6→Γ6, L6 scattering time in GaAs measured by ultrafast pump-probe infrared absorption spectroscopy

A direct measurement of the dynamics of electrons in the X₆ valley for a GaAs crystal by time-resolved absorption spectroscopy is reported for the first time. IR picosecond probe pulses were used to monitor the growth and decay of the population in the X₆ valley subsequent to excitation by a 527 nm pump pulse. The intervalley X₆→Γ₆, L₆ scattering time t_x of 0.70 ± 0.50 ps is determined and the crossection for the X₆→X₇ transition is estimated to be 1.8 × 10⁻¹⁶ cm².