Characterization of the detergent insolubility of the T cell receptor for antigen

Aggregation of cell surface receptors plays an important role in signal transduction in many receptor systems. In the T cell receptor (TCR), as in many other cell surface receptors, this aggregation results in insolubility in certain nonionic detergents. We have characterized this insolubility for TCR, and we show it is not preexisting in HPB-ALL cells but increases with increasing TCR aggregation. It is not likely to be due to a direct interaction with cellular cytoskeletal elements, as it is not affected by inhibitors of actin or tubulin polymerization. It may be due to interaction with detergent-resistant membrane domains that have been found in various cell types and contain tyrosine kinases, the earliest known participants in TCR signal transduction. This aggregation-dependent insolubility occurs as rapidly as the anti-TCR antibody binds, so the kinetics are consistent with an involvement in signal transduction. It is not, however, dependent on signal transduction, as inhibitors of tyrosine kinases do not inhibit the insolubility. Insolubility is also enhanced by preaggregation of CD4, an important T cell surface molecule which also associates with the tyrosine kinase p56lck.     

Studies on the structural and ionic transport properties at elevated temperatures of La1−xMnO3±δ synthesized by a wet chemical method

Structural transformation and ionic transport properties are investigated on wet-chemically synthesized La_1−xMnO₃ (x=0.0–0.18) compositions. Powders annealed in oxygen/air at 1000–1080 K exhibit cubic symmetry and transform to rhombohedral on annealing at 1173–1573 K in air/oxygen. Annealing above 1773 K in air or in argon/helium at 1473 K stabilized distorted rhombohedral or orthorhombic symmetry. Structural transformations are confirmed from XRD and TEM studies. The total conductivity of sintered disks, measured by four-probe technique, ranges from 5 S cm⁻¹ at 298 K to 105 S cm⁻¹ at 1273 K. The ionic conductivity measured by blocking electrode technique ranges from 1.0×10⁻⁶ S cm⁻¹ at 700 K to 2.0×10⁻³ S cm⁻¹ at 1273 K. The ionic transference number of these compositions ranges from 3.0×10⁻⁵ to 5.0×10⁻⁵ at 1273 K. The activation energy deduced from experimental data for ionic conduction and ionic migration is 1.03–1.10 and 0.80–1.00 eV, respectively. The activation energy of formation, association and migration of vacancies ranges from 1.07 to 1.44 eV.     

Enhanced anti-biofilm activity of facile synthesized silver oxide nanoparticles against K. pneumoniae

Journal of Inorganic and Organometallic Polymers and Materials - The silver oxide nanoparticle was successfully synthesized using floral waste by simple one pot, cost effective method. The complete...     

Water Desalination a perspective for membrane processes in India

A crying need of the day in India is to supply safe drinking water to its villages, towns and cities. Though the urban needs are partially met by organized water supply schemes, acute water shortages are felt at various times in this sector also with the expanding industrialization of the country. In many areas of arid and semi-arid regions, only brackish waters are available which are unfit for human consumption.Research and development effort at CSMCRI on the two membrane processes, reverse osmosis and electrodialysis, during the past decade has been reviewed. Some of the current activities in the rural sector and the future potential for these two processes in tackling the pressing needs of potable water to the rural masses in India are outlined. In the industrial sector, these two processes have immense potentialities in pollution abatement and water reuse.     

Performance Preserving Topological Downscaling of Internet-Like Networks

The Internet is a large, heterogeneous system operating at very high speeds and consisting of a large number of users. Researchers use a suite of tools and techniques in order to understand the performance of complex networks like the Internet: measurements, simulations, and deployments on small to medium-scale testbeds. This work considers a novel addition to this suite: a class of methods to scale down the topology of the Internet that enables researchers to create and observe a smaller replica, and extrapolate its performance to the expected performance of the larger Internet. This is complementary to the work of Psounis, 2003, where the authors presented a way to scale down the Internet in time, by creating a slower replica of the original system. The key insight that we leverage in this work is that only the congested links along the path of each flow introduce sizable queueing delays and dependencies among flows. Hence, one might hope that the network properties can be captured by a topology that consists of the congested links only. Using extensive simulations with transmission control protocol (TCP) traffic and theoretical analysis, we show that it is possible to achieve this kind of performance scaling even on topologies the size of the CENIC backbone (that provides Internet access to higher education institutions in California). We also show that simulating a scaled topology can be up to two orders of magnitude faster than simulating the original topology     

Brazil’s new national policy on solid waste: challenges and opportunities

Brazil, one of the world’s largest developing countries, has recently introduced a new solid waste management regulatory policy. This new regulatory policy will have implications for a wide variety of stakeholders and sets the stage for opportunities and lessons to be learned. These issues are discussed in this article.     

Analysing green supply chain management practices in Brazil’s electrical/electronics industry using interpretive structural modelling

Industries need to adopt the environmental management concepts in the traditional supply chain management. The green supply chain management (GSCM) is an established concept to ensure environment-friendly activities in industry. This paper identifies the relationship of driving and dependence that exists between GSCM practices with regard to their adoption within Brazilian electrical/electronic industry with the help of interpretive structural modelling (ISM). From the results, we infer that cooperation with customers for eco-design practice is driving other practices, and this practice acts as a vital role among other practices. Commitment to GSCM from senior managers and cooperation with customers for cleaner production occupy the highest level.     

Directed diffusion for wireless sensor networking

Advances in processor, memory, and radio technology enable small and cheap nodes capable of sensing, communication, and computation. Networks of such nodes can coordinate to perform distributed sensing of environmental phenomena. We explore the directed diffusion paradigm for such coordination. Directed diffusion is data-centric in that all communication is for named data. All nodes in a directed-diffusion-based network are application aware. This enables diffusion to achieve energy savings by selecting empirically good paths and by caching and processing data in-network (e.g., data aggregation). We explore and evaluate the use of directed diffusion for a simple remote-surveillance sensor network analytically and experimentally. Our evaluation indicates that directed diffusion can achieve significant energy savings and can outperform idealized traditional schemes (e.g., omniscient multicast) under the investigated scenarios.     

Size and morphology-controlled synthesis of mesoporous hydroxyapatite nanocrystals by microwave-assisted hydrothermal method

We report the rapid microwave-assisted hydrothermal synthesis of mesoporous hydroxyapatite (HAp) nanocrystals with controlled size, morphology, and surface area using various organic modifiers as regulators. The products were analyzed for their crystalline nature, phase purity, morphology, particle size and pore size distribution. Results indicated that ascorbic acid, cetyltrimethyl ammonium bromide (CTAB) and polyvinylpyrrolidone (PVP) play an important role to obtain needle like, rod like and fiber like mesoporous HAp nanocrystals with different specific surface area by controlling growth habit of HAp along c-axis. In addition, the prepared samples were B-type carbonated HAp similar to bone minerals. Therefore, the present approach can be a promising way to obtain precursor for making tissue engineering scaffolds, drug/protein delivery carriers and bone fillers with tunable characteristics.