全文获取类型
收费全文 | 627篇 |
免费 | 25篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 6篇 |
综合类 | 1篇 |
化学工业 | 97篇 |
金属工艺 | 10篇 |
机械仪表 | 19篇 |
建筑科学 | 25篇 |
能源动力 | 20篇 |
轻工业 | 53篇 |
水利工程 | 5篇 |
石油天然气 | 1篇 |
武器工业 | 1篇 |
无线电 | 59篇 |
一般工业技术 | 100篇 |
冶金工业 | 196篇 |
原子能技术 | 2篇 |
自动化技术 | 59篇 |
出版年
2023年 | 8篇 |
2022年 | 10篇 |
2021年 | 15篇 |
2020年 | 14篇 |
2019年 | 17篇 |
2018年 | 9篇 |
2017年 | 18篇 |
2016年 | 18篇 |
2015年 | 17篇 |
2014年 | 23篇 |
2013年 | 34篇 |
2012年 | 24篇 |
2011年 | 42篇 |
2010年 | 24篇 |
2009年 | 18篇 |
2008年 | 29篇 |
2007年 | 17篇 |
2006年 | 19篇 |
2005年 | 11篇 |
2004年 | 9篇 |
2003年 | 10篇 |
2002年 | 4篇 |
2001年 | 9篇 |
2000年 | 5篇 |
1999年 | 9篇 |
1998年 | 47篇 |
1997年 | 33篇 |
1996年 | 30篇 |
1995年 | 20篇 |
1994年 | 17篇 |
1993年 | 15篇 |
1992年 | 4篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1988年 | 9篇 |
1987年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 9篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1971年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有654条查询结果,搜索用时 15 毫秒
1.
Photoinduced cross-links between the iodinated Lys26-p-azidobenzoyl derivative of neurotoxin II from Naja naja oxiana cobra venom and nicotinic acetylcholine receptor from Torpedo californica (AChR) have been studied in the presence of alpha-conotoxin GI from the marine snail C. geographus. Preincubation of the AChR-enriched membranes with increasing concentrations of alpha-conotoxin GI protects first the gamma subunit from photolabelling and then the delta subunit, the IC50 values being 0.76 and 5.01 microM, respectively. The results obtained, in view of the relevant data in literature, demonstrate that the (alpha + gamma) site, which is the high affinity site for d-tubocurarine, has also a higher affinity for an alpha-conotoxin than the (alpha + delta) containing site. The latter has a somewhat higher affinity than the (alpha + gamma) site towards some naturally occurring snake venom alpha-neurotoxins or their derivatives. 相似文献
2.
A semi-quantitative right coronary artery score (RCA score) was derived from the ratio of the number of the major left ventricular branches of the right coronary artery to the total of the right coronary and left circumflex arteries, to stratify the extent of perfusion in patients with right coronary artery dominance. Thirty-seven patients with one-vessel coronary disease involving a dominant right coronary artery proximal to the left ventricular branches were selected for study. Thallium scintigraphy was performed after right intracoronary injection in 11 patients, and 26 patients underwent conventional stress thallium scintigraphy (24 exercise thallium and two dipyridamole thallium scintigraphy). Thallium scores of perfusion region size after right intracoronary thallium injection and perfusion defect size in stress thallium studies were quantitated from planar thallium images. Both the RCA score and the regional thallium scores spanned over a wide range. The RCA score (range 0.23-0.85) correlated best with the posterior (70 degrees left anterior oblique view) plus lateral segment (40 degrees left anterior oblique view) thallium score (r = 0.88 and 0.53 for intracoronary and stress thallium studies respectively). It also correlated with the summed thallium scores in the posterior, lateral, apical and inferior segments (r = 0.73 and 0.54 respectively) but not with thallium scores in the apex or inferior segment alone. The proposed RCA score quantitates the variable posterolateral perfusion territory of the right coronary artery, and could stratify the area of myocardium at risk from coronary stenosis in the majority of patients with right coronary dominance. 相似文献
3.
4.
Deactivation of copper-ion-exchanged hydrogen-mordenite-type zeolite catalyst by SO2 for NO reduction by NH3 was examined in a fixed-bed flow reactor. The deactivation of the catalyst was strongly dependent on reaction temperature. At high reaction temperatures over 300°C, the catalyst did not lose its initial activity up to 50 h of operation, regardless of SO2 feed concentration from 500 to 20,000 ppm. However, at low reaction temperatures near 250°C, apparent deactivation did occur. Changes in the physicochemical properties such as surface area and sulfur content of deactivated catalyst well correlated with catalyst activity, depending upon reaction temperatures. The deactivation was due to pore blocking and/or filling by deactivating agents, which plugged and/or filled the pores of catalyst. The deactivating agents deposited on the catalyst surface were presumed to be (NH4)2SO4 and/or (NH4)HSO4 from the results of TGA and ion-chromatography measurement. 相似文献
5.
Database considerations in manufacturing systems integration 总被引:1,自引:0,他引:1
This paper deals with ideas that could form a basis for manufacturing integration. In recent times more attention is being paid to the idea of applying artificial intelligence (AI) techniques to manufacturing. However, very little attention is being paid to the proper use of these techniques. This research work explores three basic ideas:
1. 1. Applications of the entity-relationship approach to knowledge representation.
2. 2. The basic philosophy of expert database systems and
3. 3. Integration of manufacturing systems from the above two concepts.
The approaches for 1 and 2 are explained with actual implementation experiences, while a framework for integration is proposed from a more philosophical perspective. 相似文献
6.
Uncertainty in water quality model predictions is inevitably high due to natural stochasticity, model uncertainty, and parameter uncertainty. An integrated modelling system (modified-BASINS) under uncertainty is described and demonstrated for use in receiving-water quality prediction and watershed management. A Monte Carlo simulation was used to investigate the effect of various uncertainty types on output prediction. Without pollution control measures in the watershed, the concentrations of total nitrogen (T-N) and total phosphorus (T-P) in the Hwaong Reservoir, considering three uncertainty types, would be less than about 4.4 and 0.23 mg L(-1), respectively, in 2012, with 90% confidence. The effects of two watershed management practices, wastewater treatment plants (WWTP) and constructed wetlands (WETLAND), were evaluated. The combined scenario (WWTP + WETLAND) was the most effective at improving reservoir water quality, bringing concentrations of T-N and T-P in the Hwaong Reservoir to less than 3.4 and 0.14 mg L(-1), 24 and 41% improvements, respectively, with 90% confidence. Overall, the Monte Carlo simulation in the integrated modelling system was practical for estimating uncertainty and reliable in water quality prediction. The approach described here may allow decisions to be made based on the probability and level of risk, and its application is recommended. 相似文献
7.
Ju Ri Ham Ra-Yeong Choi Yongjin Lee Mi-Kyung Lee 《International journal of molecular sciences》2021,22(7)
Mealworms (Tenebrio molitor larva) are an edible insect and a protein-rich food; however, research on mealworms as a substitute protein is insufficient. In this study, mealworm fermentation extract (TMP) was assessed as a replacement for soy protein (SP) in a control diet (CON) or a high-fat diet (HFD) of mice for 12 weeks. TMP substitution reduced body weight, body weight gain, body fat mass (perirenal and mesenteric), fat size, glucose intolerance, and insulin resistance compared to the HFD-SP group. TMP alleviated hepatic steatosis (lipid contents and lipid droplets) in high-fat-fed mice and down-regulated the PPARγ, CD36, and DGAT2 gene levels. Proteomic analysis showed that a HFD for 12 weeks up-regulated 20 proteins and down-regulated 17 proteins in mice fed SP. On the other hand, TMP reversed the protein profiles. TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group. These proteins are involved in the glucose, lipid, and amino acid metabolism, as well as in oxidative stress and endoplasmic reticulum stress. Thus, substituting SP for TMP helped improve HFD-induced obesity, steatosis, and insulin resistance in mice. These results suggest that TMP is a potential substitute for commonly used protein sources. 相似文献
8.
Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2 总被引:2,自引:0,他引:2
Reed C; Fu ZQ; Wu J; Xue YN; Harrison RW; Chen MJ; Weber IT 《Protein engineering, design & selection : PEDS》1997,10(10):1101-1107
Crystal structures have been determined of recombinant human tumor necrosis
factor-alpha (TNF-alpha) and its R31D mutant that preferentially binds to
TNF receptor R1 with more than seven times the relative affinity of binding
to receptor R2. Crystals of the wild-type TNF were of space group
P4(1)2(1)2 and had unit cell dimensions of a = b = 94.7 and c = 117.4 A.
Refinement of the structure gave an R-factor of 22.3% at 2.5 A resolution.
The crystals of TNF R31D mutant diffracted to 2.3 A resolution, and were of
identical space group to the wild type with unit cell dimensions of a = b =
95.4 and c = 116.2 A, and the structure was refined to an R-factor of
21.8%. The trimer structures of the wild-type and mutant TNF were similar
with a root mean square (r.m.s.) deviation of 0.56 A for Calpha atoms;
however, the subunits within each trimer were more variable with an average
r.m.s. deviation of 1.00 A on Calpha atoms for pairwise comparison of
subunits. Model complexes of TNF with receptors R1 and R2 have been used to
predict TNF-receptor interactions. Arg31 in all three subunits of wild-type
TNF is predicted to form an ionic interaction with the equivalent glutamic
acid in both receptors R1 and R2. Asp31 of the TNF R31D mutant is predicted
to interact differently with the two receptors. The side chain of Asp31 in
two subunits of the TNF mutant is predicted to form hydrogen bond
interactions with Ser59 or Cys70 of R1, while it has no predicted
interactions with R2. The loss of three strong ionic interactions of Arg31
and the electrostatic repulsion of Asp31 with Glu in the receptors is
consistent with the reduced binding of the R31D mutant to both receptors
relative to wild-type TNF. The replacement of these ionic interactions by
two weaker hydrogen bond interactions between Asp31 of the R31D mutant and
R1, compared with no interactions with R2, is in agreement with the
observed preferential binding of the R31D mutant to R1 over R2. Analysis of
the structure and function of receptor-discriminating mutants of TNF will
help understand the biological role of TNF and facilitate its use as an
antitumor agent.
相似文献
9.
Polyvinylpyrrolidone (PVP)/sodium montmorillonite (MMT) nanocomposites prepared via the solution intercalation method were investigated by UV/vis, SEM, X-ray diffraction, TEM, FT-IR and PLM (polarized light microscopy). PVP/MMT nanocomposites show exfoliation below 20 wt% MMT and intercalation above this concentration. Nanocomposites retain good optical clarity and increased thermal resistance with MMT content. The compatibility between PVP and MMT and their enhanced properties may be explained by hydrogen bonding interactions. In addition, the nanocomposites prepared under more rigorous mixing conditions show better transparency because the smaller particle sizes are induced. In addition, the study on optically clear PVP/MMT suspensions helps one to understand how optical anisotropy of MMT is affected by the existence of polymer in aqueous solution. 相似文献
10.
Single Point Incremental Forming (SPIF) is a modern method of forming sheet metal, where parts can be formed without the use of dedicated dies. The ability of SPIF to form a part is based on various forming parameters. Previous work was not accomplished with the help of design of experiments, thus reducing the number of parameters varied at any time. This paper presents two designs of experiments, which formalise the forming parameters critical in SPIF and the degree to which they affect formability. 相似文献