Formulation and in vitro Evaluation of pH-Sensitive Cross-linked Xanthan Gum-Grafted Acrylic Acid Copolymer for Controlled Delivery of Perindopril Erbumine (PE)

A novel xanthan gum-co-acrylic acid superabsorbent hydrogel composite was formulated by free radical polymerization reaction of acrylic acid on xanthan gum. Effect of variables like dynamic swelling ratio, equilibrium swelling ratio, drug loading and drug release was investigated. Swelling ratio increases with decrease in crosslinker concentration. Drug release studies were conducted in pH 7.4 and 0.1N HCl. In acidic environment, drug release was low whereas it was sustained release in alkaline. XG4 showed significant swelling and drug release up to 24?hr. Physicochemical evaluation also confirmed it was optimized formulation. Hence XG4-co-AA was optimized for once daily dose of Perindopril Erbumine.     

Membrane topology and glycosylation of the human multidrug resistance-associated protein

The membrane topology of the human multidrug resistance-associated protein (MRP) was examined by flow cytometry phenotyping, immunoblotting, and limited proteolysis in drug-resistant human and baculovirus-infected insect cells, expressing either the glycosylated or the underglycosylated forms of this protein. Inhibition of N-linked glycosylation in human cells by tunicamycin did not inhibit the transport function or the antibody recognition of MRP, although its apparent molecular mass was reduced from 180 kDa to 150 kDa. Extracellular addition of trypsin or chymotrypsin had no effect either on the function or on the molecular mass of MRP, while in isolated membranes limited proteolysis produced three large membrane-bound fragments. These experiments and the alignment of the MRP sequence with the human cystic fibrosis transmembrane conductance regulator (CFTR) suggest that human MRP, similarly to CFTR, contains a tandem repeat of six transmembrane helices, each followed by a nucleotide binding domain, and that the C-terminal membrane-bound region is glycosylated. However, the N-terminal region of MRP contains an additional membrane-bound, glycosylated area with four or five transmembrane helices, which seems to be a characteristic feature of MRP-like ATP-binding cassette transporters.     

Smart home security: challenges,issues and solutions at different IoT layers

The Journal of Supercomputing - The Internet of Things is a rapidly evolving technology in which interconnected computing devices and sensors share data over the network to decipher different...     

An Insight View on Synthetic Protocol,Surface Activity,and Biological Aspects of Novel Biocompatible Quaternary Ammonium Cationic Gemini Surfactants

In this study, we prepared a novel series of diester-functionalized cationic gemini surfactants (C_m-E2O2-C_m) containing ethylene oxide as a spacer with varying alkyl chain lengths and characterized by ¹H NMR, FT-IR, elemental analysis, and ESI-MS. The physicochemical properties of the geminis were explored by tensiometry, fluorescence, dye solubilization, and Krafft point. These geminis acquire superior surface activity than the conventional surfactants. Fluorescence spectroscopy analysis affirmed that the micropolarity and aggregation number of micelles diminished with increase in the alkyl chain length. These geminis represent a new group of amphiphiles of considerably high biodegradability, better cleavability, and low toxicity as assessed by BOD test, FT-IR analysis, and HC₅₀ analysis, respectively. They also showed significant level of antimicrobial activity toward some specified bacterial strains of Gram-positive and Gram-negative by using agar well diffusion method. Furthermore, the thermogravimetric analysis provided information regarding thermal stabilities of the newly synthesized gemini surfactants.     

Graft Copolymerization of Acrylamide onto Oil Palm Empty Fruit Bunch (OPEFB) Fiber

Grafting of acrylamide (AAm) onto oil palm empty fruits bunch fiber using hydrogen peroxide as initiator and methyl acrylate as comonomer was investigated. The amount of comonomer needed to make grafting of acrylamide possible was determined. The percentage of poly(acrylamide) and the comonomer in the final graft copolymer was estimated by elemental analysis. Results obtained indicated that methyl acrylate facilitated the incorporation of acrylamide monomer onto OPEFB. The reactivity ratios for both monomers were determined by using Fineman–Ross plot. The effects of reaction temperature and period as well as amount of the initiator, solvent, monomer and comonomer on the percentage of grafting at fixed amount of comonomer (11 mmol) were studied. Maximum percentage of grafting was achieved when the amount of initiator and solvent 3.98×10⁻³ mol and 50 mL respectively. The optimum reaction temperature was 50 ^○C and the reaction period was 90 min. Highest percentage of grafting was 232% when 25.6 mmol of acrylamide was used under these optimum conditions. The presence of functional group in the grafted polymer is characterized by infrared spectroscopy and the surface morphology is observed by scanning electron microscopy. Thermoanalytic investigation on OPEFB and OPEFB-g-PAAM were carried out to evaluate the thermal stability and respective activation energy of the materials.     

Robust face recognition against expressions and partial occlusions

Facial features under variant-expressions and partial occlusions could have degrading effect on overall face recognition performance. As a solution, we suggest that the contribution of these features on final classification should be determined. In order to represent facial features contribution according to their variations, we propose a feature selection process that describes facial features as local independent component analysis(ICA) features. These local features are acquired using locally lateral subspace(LLS) strategy.Then, through linear discriminant analysis(LDA) we investigate the intraclass and interclass representation of each local ICA feature and express each feature s contribution via a weighting process. Using these weights, we define the contribution of each feature at local classifier level. In order to recognize faces under single sample constraint, we implement LLS strategy on locally linear embedding(LLE) along with the proposed feature selection. Additionally, we highlight the efficiency of the implementation of LLS strategy. The overall accuracy achieved by our approach on datasets with different facial expressions and partial occlusions such as AR, JAFFE,FERET and CK+ is 90.70%. We present together in this paper survey results on face recognition performance and physiological feature selection performed by human subjects.     

Design of backpropagated neurocomputing paradigm for Stuxnet virus dynamics in control infrastructure

Neural Computing and Applications - In the present study, a novel application of backpropagated neurocomputing heuristics (BNCH) is presented for epidemic virus model that portrays the Stuxnet...     

On the Efficiency of Runs Rules Schemes for Process Monitoring

There are two main types of variations, namely, common and special causes leading to in‐control and out‐of‐control states, respectively. Control charts are popular tools used to differentiate between these two states of a process. Implementation of runs rules schemes with control charts is an attractive approach for process monitoring. This study is designed to describe the methodology of runs rules schemes and discuss their implementation for different types of control charts. We have considered memory‐less charts, namely, , S, and R charts for our study purposes. It is examined that the efficiency gain depends on the number of decision points utilized to implement a given rule. Moreover, superiority of runs rules schemes may vary for different types of location and dispersion charts. An application example using a dataset is also included in the study for practical considerations. Copyright © 2015 John Wiley & Sons, Ltd.     

WiMA: Towards a Multi-Criterion Association in Software Defined Wi-Fi Networks

Despite the planned installation and operations of the traditional IEEE 802.11 networks, they still experience degraded performance due to the number of inefficiencies. One of the main reasons is the received signal strength indicator (RSSI) association problem, in which the user remains connected to the access point (AP) unless the RSSI becomes too weak. In this paper, we propose a multi-criterion association (WiMA) scheme based on software defined networking (SDN) in Wi-Fi networks. An association solution based on multi-criterion such as AP load, RSSI, and channel occupancy is proposed to satisfy the quality of service (QoS). SDN having an overall view of the network takes the association and reassociation decisions making the handoffs smooth in throughput performance. To implement WiMA extensive simulations runs are carried out on Mininet-NS3-Wi-Fi network simulator. The performance evaluation shows that the WiMA significantly reduces the average number of retransmissions by 5%–30% and enhances the throughput by 20%–50%, hence maintaining user fairness and accommodating more wireless devices and traffic load in the network, when compared to traditional client-driven (CD) approach and state of the art Wi-Balance approach.