Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications

Mesenchymal stem cells (MSCs) are the main cell players in tissue repair and thanks to their self-renewal and multi-lineage differentiation capabilities, they gained significant attention as cell source for tissue engineering (TE) approaches aimed at restoring bone and cartilage defects. Despite significant progress, their therapeutic application remains debated: the TE construct often fails to completely restore the biomechanical properties of the native tissue, leading to poor clinical outcomes in the long term. Pulsed electromagnetic fields (PEMFs) are currently used as a safe and non-invasive treatment to enhance bone healing and to provide joint protection. PEMFs enhance both osteogenic and chondrogenic differentiation of MSCs. Here, we provide extensive review of the signaling pathways modulated by PEMFs during MSCs osteogenic and chondrogenic differentiation. Particular attention has been given to the PEMF-mediated activation of the adenosine signaling and their regulation of the inflammatory response as key player in TE approaches. Overall, the application of PEMFs in tissue repair is foreseen: (1) in vitro: to improve the functional and mechanical properties of the engineered construct; (2) in vivo: (i) to favor graft integration, (ii) to control the local inflammatory response, and (iii) to foster tissue repair from both implanted and resident MSCs cells.     

Experimental results of a solar assisted heat pump rice drying system

In the last rice harvest season, experimental results have been obtained on the efficiency and drying quality of a solar assisted heat pump drying prototype system. The system has been operated as a solar and heat pump system and drying curves for the different options have been obtained. The advantage of the low temperature and better control in the drier shows that the heat pump assisted solar drying system is an excellent alternative to traditional drying systems.     

Geometric criteria of hydrogen bonds in proteins and identification of `bifurcated' hydrogen bonds

Empirical criteria for identification of hydrogen bonds wereanalyzed to produce a set of geometrically consistent criteria.For a data set of 30 structures, application of a set of purelygeometrical criteria, along with exclusion of abnormal backboneconformations, also excluded a common interaction of Ser/Thrside chains with Asp/Glu side chains ([ST]/[DE] pairs). Theseinteractions were termed `bifurcated hydrogen bonds/', whichimplies delocalization of a positively charged hydrogen of hydroxylbetween the two acceptor atoms of the carboxylic group. These`bifurcated/' interactions are among the most common packingpatterns for [ST]/[DE] pairs of side chains. Therefore, theidentification of hydrogen bonds cannot be based on geometricalcriteria only and requires introduction of some physico-chemicalcriteria.     

A new technique for on-line and off-line high speed computation

A novel technique for both online and offline computation is presented. With this technique, a reconstruction analysis in elementary particle physics, otherwise prohibitively long, has been accomplished. It will be used online in an upcoming Fermilab experiment to reconstruct more than 100000 events per second and to trigger on the basis of that information. The technique delivers 40 gigaoperations per second, has a bandwidth on the order of gigabytes per second, and has a modest cost. An overview of the program, details of the system, and performance measurements are presented     

Feminist identity and feminist therapy behaviors of women psychotherapists.

Investigated whether (1) feminist identity development for women therapists was related to their use of feminist therapy behaviors (FTBs) and (2) feminist identity development and use of FTBs for women therapists were related to self-identification as a feminist therapist. 153 women psychologists (aged 30–77 yrs) were administered a women's issues in therapy questionnaire, which included a short version of the Feminist Identity Scale (FIS; K. M. Rickard, 1989, 1990). Ss were categorized into stages of feminine identity development according to their scores on 4 subscales of the FIS: Passive-Acceptance (PA), Revelation (REV), Embeddedness (EMB), and Synthesis (SYN). Ss scoring high on SYN and REV, and low on PA, reported greater use of FTBs; scores on the EMB were not related to the use of FTBs. All 4 subscales were predictive of women therapists who self-identified as feminist therapists. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Family burden following traumatic brain injury.

Investigated burden experienced by 60 spouses and 71 parents who served as primary caregivers to individuals with traumatic brain injury (BI). Burden levels, as assessed by the Questionnaire on Resources and Stress (QRS-SF), were compared for spouses and parents. Both parents and spouses exhibited high levels of burden. Relative to spouses, parents reported significantly greater burden related to lifespan care. Spouses reported significantly less personal reward than did parents. The presence of social aggression and cognitive disability in the individual with BI was found to have a greater association with subjective burden of caregivers than was the presence of physical disability or injury severity. Results of previous studies with QRS-SF scores show that the responsibility assumed by spouses and parents of persons with BI was as great as that experienced by families of people with severe chronic physical disabilities. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On the linear and nonlinear complexity profile of nonlinear pseudorandom number generators

We obtain lower bounds on the linear and nonlinear complexity profile of a general nonlinear pseudorandom number generator, of the inversive generator, and of a new nonlinear generator called quadratic exponential generator. The results are interesting for applications to cryptography and Monte Carlo methods.     

Effect of Dilution and Porosity on Self-Propagating High-Temperature Synthesis of Silicon Nitride

Self-propagating high-temperature synthesis is a very easy and low-cost method to synthesize Si₃N₄. The nitriding of silicon powder takes place in a self-sustained regime under high pressures of nitrogen with dilution of silicon by Si₃N₄. In this work effects of dilution and green-mixture porosity on combustion velocity and phase content of reaction products are studied. Results are compared with previous work of other authors and different behaviors are found. An explanation of these behaviors is given.     

On transitive orientations with restricted covering graphs

We consider the problem of finding a transitive orientation of a comparability graph, such that the edge set of its covering graph contains a given subset of edges. We propose a solution which employs the classical technique of modular tree decomposition. The method leads to a polynomial time algorithm to construct such an orientation or report that it does not exist.